Q5RFQ9 (ABCB8_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial

Gene names

Name:

ABCB8

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Monomer Potential.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 38	38	Mitochondrion By similarity
	Chain	39 – 718	680	ATP-binding cassette sub-family B member 8, mitochondrial		PRO_0000356234
Regions
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	279 – 299	21	Helical; Potential
	Transmembrane	366 – 386	21	Helical; Potential
	Domain	131 – 420	290	ABC transmembrane type-1
	Domain	455 – 692	238	ABC transporter
	Nucleotide binding	490 – 497	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5RFQ9 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 4DB86585C1F1EA95	FASTA	718	78,186
	10 20 30 40 50 60 MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRYSDGYRSS SLFWAVAHLR SQLWAHLPRA 70 80 90 100 110 120 PLAPRWSPSA WCWVGGALLG PMVLSKHPHL CLVALCEAEE ATPASSTPHV VGSRFNWKLF 130 140 150 160 170 180 WQFLRPHLLV LGVAVVLALG AALVNVQIPL LLGQLVEIVA KYTRDHVGSF MTESQNLSTH 190 200 210 220 230 240 LLILYGVQGL LTFGYLVLLS HVGERMAVDM RRALFSSLLR QDIAFFDANK TGQLVSRLTT 250 260 270 280 290 300 DVQEFKSSFK LVISQGLRSC TQVAGCLVSL SMLSTRLTLL LMLATPALMG VGTLMGSGLR 310 320 330 340 350 360 KLSRQCQEQI ARAMGVADEA LGNVRTVRAF AMEQREEERY GAELEACRCR AEELGRGIAL 370 380 390 400 410 420 SQGLSNIAFN CMVLGTLFIG GSLVAGQQLT GGDLMSFLVA SQTVQRSMAN LSVLFGQVVR 430 440 450 460 470 480 GLSAGARVFE YMALNPCIPL SGGCCVPKEQ LRGSVTFQNV CFSYPCRPGF EVLKDFTLTL 490 500 510 520 530 540 PPGKIVALVG QSGGGKTTVA SLLERFYDPT AGVVMLDGRD LRTLDPSWLR GQVVGFISQE 550 560 570 580 590 600 PVLFGTTIME NIRFGKLEAS DEEVYAAARE ANAHEFITSF PEGYNTIVGE RGTTLSGGQK 610 620 630 640 650 660 QRLAIARALI KQPTVLILDE ATSALDAESE RVVQEALDRA SAGRTVLVIA HRLSTVRGAH 670 680 690 700 710 RIVVMADGRV WEAGTHEELL KKGGLYAELI RRQALDAPRT AAPLPKKPEG PRNHQHKS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857093 mRNA. Translation: CAH89398.1.
RefSeq	NP_001124589.1. NM_001131117.1.
UniGene	Pab.12178.
3D structure databases
ProteinModelPortal	Q5RFQ9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100171425.
KEGG	pon:100171425.
Organism-specific databases
CTD	11194.
Phylogenomic databases
HOVERGEN	HBG008358.
KO	K05655.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCB8_PONAB

Accession

Primary (citable) accession number: Q5RFQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	December 21, 2004
Last modified:	May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program