Reviewed, UniProtKB/Swiss-Prot Q5RFM9 (FTHFD_PONAB)

Names and origin

Protein names

Recommended name:
    10-formyltetrahydrofolate dehydrogenase
      Short name=10-FTHFDH
    EC=1.5.1.6
Alternative name(s):
    Aldehyde dehydrogenase family 1 member L1

Gene names

Name:	ALDH1L1
Synonyms:	FTHFD

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	902 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	In the N-terminal section; belongs to the GART family. In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NADP Phosphopantetheine
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	10-formyltetrahydrofolate catabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon compound metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro formyltetrahydrofolate dehydrogenase activity Inferred from electronic annotation. Source: InterPro hydroxymethyl-, formyl- and related transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 902	902	10-formyltetrahydrofolate dehydrogenase		PRO_0000199421
Regions
	Domain	323 – 392	70	Acyl carrier
	Region	1 – 203	203	GART
	Region	417 – 902	486	Aldehyde dehydrogenase
Sites
	Active site	106	1	Proton donor By similarity
	Active site	673	1	By similarity
	Active site	707	1	By similarity
	Binding site	354	1	Phosphopantetheine (covalent) By similarity
	Site	142	1	Essential for catalytic activity By similarity
Amino acid modifications
	Modified residue	354	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RFM9-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: C15ED0836C4CC789	FASTA	902	98,850
	10 20 30 40 50 60 MKIAVIGQSL FGQEVYCHLR KEGHEVVGGF TVPDKDGKAD PLGLEAEKDG VPVFKFSRWR 70 80 90 100 110 120 AKGQALPDVV AKYQALGAEL NVLPFCSQFI PMEIINAPQH GSIIYHPSLL PRHRGASAIN 130 140 150 160 170 180 WTLIHGDKKG GFSIFWADDG LDTGDLLLQK ECEVLPDDTV STLYNRFLFP EGIKGMVQAV 190 200 210 220 230 240 RLIAEGKAPR LPQPEEGATY EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACEQ 250 260 270 280 290 300 KLTFFNSTLN TSGLVPEGDA LPIPGAHRPG VVTKAGLILF GNDDKMLLVK NIQLEDGKMI 310 320 330 340 350 360 LASNFFKGAA SSALELTEAE LVTAEAVRSV WQRILPNVLE VEDSTDFFKS GAASVDVVRL 370 380 390 400 410 420 VEEVKELCDG LELENEDVYM ASTFGDFIQL LVRKLRGDDE EGECSIDYVE MAVNKRTIRI 430 440 450 460 470 480 PHQLFIGGEF VDAEGAKTYE TINPTDGSVI CQVSLAQVTD VDKAVAAAKD AFENGRWGKI 490 500 510 520 530 540 SARDRGRLLY RLADLMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI 550 560 570 580 590 600 QGSTIPINQA RPNRNLTLTR KEPVGVCGII IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 610 620 630 640 650 660 VTPLTALKFA ELTLKAGIPK GVVNVLPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK 670 680 690 700 710 720 SCAISNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEDSIH 730 740 750 760 770 780 DEFVRRVVEE VRKMKVGDPL DRDTDHGPQN HHAHLMKLME YCQRGVKEGA TLVCGGNQVP 790 800 810 820 830 840 RPGFFFEPTV FTDVEDHMFI AKEESFGPVM IISRFADGDV DTVLSRANAT EFGLASGVFT 850 860 870 880 890 900 RDINKALYVS DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRVKTVTF EY

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857124 mRNA. Translation: CAH89428.1.
RefSeq	NP_001128736.1.
3D structure databases
SMR	Q5RFM9. Positions 1-307, 302-401, 406-902.
ModBase	Search...
Genome annotation databases
GeneID	100189626.
Phylogenomic databases
HOVERGEN	Q5RFM9.
Family and domain databases
InterPro	IPR011407. 10_FTHF_DHase. IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR001555. GART_AS. IPR006163. Phsphopanteth_bd. IPR006162. Ppantne_S. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. G3DSA:3.10.25.10. Formyl_trans_C. 1 hit. G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
PIRSF	PIRSF036489. 10-FTHFDH. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. PS00373. GART. 1 hit. PS00012. PHOSPHOPANTETHEINE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHFD_PONAB

Accession

Primary (citable) accession number: Q5RFM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)