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Q5RFJ3 (UD2A3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2A3

Short name=UDPGT 2A3
EC=2.4.1.17
Gene names
Name:UGT2A3
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 527504UDP-glucuronosyltransferase 2A3
PRO_0000299148

Regions

Topological domain24 – 486463Extracellular Potential
Transmembrane487 – 50721Helical; Potential
Topological domain508 – 52316Cytoplasmic Potential

Amino acid modifications

Glycosylation3131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RFJ3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 36C213B9139D6BC8

FASTA52760,200
        10         20         30         40         50         60 
MRSEKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG HEVTVLTHSK 

        70         80         90        100        110        120 
SLLIDYRKPS ALKFEVVHMP QDKTEGNEVF VDLALNVLPG LPTWQSVIKL NDFFVEIRGT 

       130        140        150        160        170        180 
LKMMCESFIY NQTLMKKLQE TNYDVMLIDP VIPCGDLMAE LLAVPFVLTL RISLGGNMER 

       190        200        210        220        230        240 
SCGKLPAPLS YVPVPMTGLT DRMTFLERVK NSMLSVFFHF WIQDYDYHFW EEFYSKALGR 

       250        260        270        280        290        300 
PTTLCETVGK AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED 

       310        320        330        340        350        360 
GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGTNTR LYDWIPQNDL 

       370        380        390        400        410        420 
LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN IAHMKAKGAA VEINFKTMTS 

       430        440        450        460        470        480 
EDLLRALRTV TTNSSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRSAAHN 

       490        500        510        520 
LTWFQHYSID VIGFLLACVA TAIFLFTKCC LFSCQKFNKT RKIEKRE 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857163 mRNA. Translation: CAH89464.1.
RefSeqNP_001127151.1. NM_001133679.2.

3D structure databases

ProteinModelPortalQ5RFJ3.
SMRQ5RFJ3. Positions 283-449.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174202.
KEGGpon:100174202.

Organism-specific databases

CTD79799.

Phylogenomic databases

HOVERGENHBG004033.
InParanoidQ5RFJ3.
KOK00699.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD2A3_PONAB
AccessionPrimary (citable) accession number: Q5RFJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families