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Q5RFJ3

- UD2A3_PONAB

UniProt

Q5RFJ3 - UD2A3_PONAB

Protein

UDP-glucuronosyltransferase 2A3

Gene

UGT2A3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
    Short name:
    UDPGT 2A3
    Gene namesi
    Name:UGT2A3
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 527504UDP-glucuronosyltransferase 2A3PRO_0000299148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RFJ3.
    SMRiQ5RFJ3. Positions 283-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 486463ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52316CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei487 – 50721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    InParanoidiQ5RFJ3.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RFJ3-1 [UniParc]FASTAAdd to Basket

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    MRSEKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG    50
    HEVTVLTHSK SLLIDYRKPS ALKFEVVHMP QDKTEGNEVF VDLALNVLPG 100
    LPTWQSVIKL NDFFVEIRGT LKMMCESFIY NQTLMKKLQE TNYDVMLIDP 150
    VIPCGDLMAE LLAVPFVLTL RISLGGNMER SCGKLPAPLS YVPVPMTGLT 200
    DRMTFLERVK NSMLSVFFHF WIQDYDYHFW EEFYSKALGR PTTLCETVGK 250
    AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED 300
    GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGTNTR 350
    LYDWIPQNDL LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN 400
    IAHMKAKGAA VEINFKTMTS EDLLRALRTV TTNSSYKENA MRLSRIHHDQ 450
    PVKPLDRAVF WIEFVMRHKG AKHLRSAAHN LTWFQHYSID VIGFLLACVA 500
    TAIFLFTKCC LFSCQKFNKT RKIEKRE 527
    Length:527
    Mass (Da):60,200
    Last modified:December 21, 2004 - v1
    Checksum:i36C213B9139D6BC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857163 mRNA. Translation: CAH89464.1.
    RefSeqiNP_001127151.1. NM_001133679.2.

    Genome annotation databases

    GeneIDi100174202.
    KEGGipon:100174202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857163 mRNA. Translation: CAH89464.1 .
    RefSeqi NP_001127151.1. NM_001133679.2.

    3D structure databases

    ProteinModelPortali Q5RFJ3.
    SMRi Q5RFJ3. Positions 283-449.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174202.
    KEGGi pon:100174202.

    Organism-specific databases

    CTDi 79799.

    Phylogenomic databases

    HOVERGENi HBG004033.
    InParanoidi Q5RFJ3.
    KOi K00699.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiUD2A3_PONAB
    AccessioniPrimary (citable) accession number: Q5RFJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3