Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-glucuronosyltransferase 2A3

Gene

UGT2A3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:UGT2A3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 486463ExtracellularSequence AnalysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence AnalysisAdd
BLAST
Topological domaini508 – 52316CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 527504UDP-glucuronosyltransferase 2A3PRO_0000299148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016512.

Structurei

3D structure databases

ProteinModelPortaliQ5RFJ3.
SMRiQ5RFJ3. Positions 283-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ5RFJ3.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSEKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG
60 70 80 90 100
HEVTVLTHSK SLLIDYRKPS ALKFEVVHMP QDKTEGNEVF VDLALNVLPG
110 120 130 140 150
LPTWQSVIKL NDFFVEIRGT LKMMCESFIY NQTLMKKLQE TNYDVMLIDP
160 170 180 190 200
VIPCGDLMAE LLAVPFVLTL RISLGGNMER SCGKLPAPLS YVPVPMTGLT
210 220 230 240 250
DRMTFLERVK NSMLSVFFHF WIQDYDYHFW EEFYSKALGR PTTLCETVGK
260 270 280 290 300
AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED
310 320 330 340 350
GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGTNTR
360 370 380 390 400
LYDWIPQNDL LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN
410 420 430 440 450
IAHMKAKGAA VEINFKTMTS EDLLRALRTV TTNSSYKENA MRLSRIHHDQ
460 470 480 490 500
PVKPLDRAVF WIEFVMRHKG AKHLRSAAHN LTWFQHYSID VIGFLLACVA
510 520
TAIFLFTKCC LFSCQKFNKT RKIEKRE
Length:527
Mass (Da):60,200
Last modified:December 21, 2004 - v1
Checksum:i36C213B9139D6BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857163 mRNA. Translation: CAH89464.1.
RefSeqiNP_001127151.1. NM_001133679.2.

Genome annotation databases

GeneIDi100174202.
KEGGipon:100174202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857163 mRNA. Translation: CAH89464.1.
RefSeqiNP_001127151.1. NM_001133679.2.

3D structure databases

ProteinModelPortaliQ5RFJ3.
SMRiQ5RFJ3. Positions 283-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016512.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174202.
KEGGipon:100174202.

Organism-specific databases

CTDi79799.

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ5RFJ3.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiUD2A3_PONAB
AccessioniPrimary (citable) accession number: Q5RFJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.