Reviewed, UniProtKB/Swiss-Prot Q5RFJ3 (UD2A3_PONAB)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2A3
      Short name=UDPGT 2A3
    EC=2.4.1.17

Gene names

Name:

UGT2A3

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 527	504	UDP-glucuronosyltransferase 2A3		PRO_0000299148
Regions
	Topological domain	24 – 486	463	Extracellular Potential
	Transmembrane	487 – 507	21	Potential
	Topological domain	508 – 523	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	313	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5RFJ3-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 36C213B9139D6BC8	FASTA	527	60,200
	10 20 30 40 50 60 MRSEKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG HEVTVLTHSK 70 80 90 100 110 120 SLLIDYRKPS ALKFEVVHMP QDKTEGNEVF VDLALNVLPG LPTWQSVIKL NDFFVEIRGT 130 140 150 160 170 180 LKMMCESFIY NQTLMKKLQE TNYDVMLIDP VIPCGDLMAE LLAVPFVLTL RISLGGNMER 190 200 210 220 230 240 SCGKLPAPLS YVPVPMTGLT DRMTFLERVK NSMLSVFFHF WIQDYDYHFW EEFYSKALGR 250 260 270 280 290 300 PTTLCETVGK AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED 310 320 330 340 350 360 GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGTNTR LYDWIPQNDL 370 380 390 400 410 420 LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN IAHMKAKGAA VEINFKTMTS 430 440 450 460 470 480 EDLLRALRTV TTNSSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRSAAHN 490 500 510 520 LTWFQHYSID VIGFLLACVA TAIFLFTKCC LFSCQKFNKT RKIEKRE

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857163 mRNA. Translation: CAH89464.1.
RefSeq	NP_001127151.1.
UniGene	Pab.19533
3D structure databases
SMR	Q5RFJ3. Positions 283-449.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
GeneID	100174202.
Phylogenomic databases
HOVERGEN	Q5RFJ3.
Enzyme and pathway databases
BRENDA	2.4.1.17. 269192.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD2A3_PONAB

Accession

Primary (citable) accession number: Q5RFJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	December 21, 2004
Last modified:	April 14, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)