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Q5RFI5

- FUCO2_PONAB

UniProt

Q5RFI5 - FUCO2_PONAB

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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei292 – 2921May be important for catalysisPROSITE-ProRule annotation

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. fucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 4967.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 465439Plasma alpha-L-fucosidasePRO_0000010314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002155.
InParanoidiQ5RFI5.
KOiK01206.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ
60 70 80 90 100
AKFGIFIHWG VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED
110 120 130 140 150
FGPLFTAKFF NANQWADIFQ ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA
160 170 180 190 200
IDEGPKRDIV KELEVAIRNR TDLRFGLYYS LFEWFHPLFL EDESSSFHKR
210 220 230 240 250
QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG FLAWLYNESP
260 270 280 290 300
VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW
310 320 330 340 350
GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER
360 370 380 390 400
LRQMGSWLKV NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW
410 420 430 440 450
PTSGQLFLGQ PKAILGATEV KLLGHGQPLN WISLERNGIM VELPQLTIHQ
460
MPCKWGWALA LTNVI
Length:465
Mass (Da):53,963
Last modified:December 21, 2004 - v1
Checksum:i820A0284528A8CEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857171 mRNA. Translation: CAH89472.1.
RefSeqiNP_001127152.1. NM_001133680.2.
UniGeneiPab.7072.

Genome annotation databases

GeneIDi100174203.
KEGGipon:100174203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857171 mRNA. Translation: CAH89472.1 .
RefSeqi NP_001127152.1. NM_001133680.2.
UniGenei Pab.7072.

3D structure databases

ProteinModelPortali Q5RFI5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174203.
KEGGi pon:100174203.

Organism-specific databases

CTDi 2519.

Phylogenomic databases

HOVERGENi HBG002155.
InParanoidi Q5RFI5.
KOi K01206.

Enzyme and pathway databases

BRENDAi 3.2.1.51. 4967.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFUCO2_PONAB
AccessioniPrimary (citable) accession number: Q5RFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3