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Q5RFI5 (FUCO2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name=Alpha-L-fucosidase 2
Gene names
Name:FUCA2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subunit structure

Homotetramer By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfucose metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalpha-L-fucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 465439Plasma alpha-L-fucosidase
PRO_0000010314

Sites

Site2921May be important for catalysis By similarity

Amino acid modifications

Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RFI5 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 820A0284528A8CEE

FASTA46553,963
        10         20         30         40         50         60 
MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ AKFGIFIHWG 

        70         80         90        100        110        120 
VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED FGPLFTAKFF NANQWADIFQ 

       130        140        150        160        170        180 
ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA IDEGPKRDIV KELEVAIRNR TDLRFGLYYS 

       190        200        210        220        230        240 
LFEWFHPLFL EDESSSFHKR QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG 

       250        260        270        280        290        300 
FLAWLYNESP VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW 

       310        320        330        340        350        360 
GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER LRQMGSWLKV 

       370        380        390        400        410        420 
NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW PTSGQLFLGQ PKAILGATEV 

       430        440        450        460 
KLLGHGQPLN WISLERNGIM VELPQLTIHQ MPCKWGWALA LTNVI 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857171 mRNA. Translation: CAH89472.1.
RefSeqNP_001127152.1. NM_001133680.2.
UniGenePab.7072.

3D structure databases

ProteinModelPortalQ5RFI5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174203.
KEGGpon:100174203.

Organism-specific databases

CTD2519.

Phylogenomic databases

HOVERGENHBG002155.
InParanoidQ5RFI5.
KOK01206.

Enzyme and pathway databases

BRENDA3.2.1.51. 4967.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUCO2_PONAB
AccessionPrimary (citable) accession number: Q5RFI5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries