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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei292May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 9017.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001031427 – 465Plasma alpha-L-fucosidaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi237N-linked (GlcNAc...)Sequence analysis1
Modified residuei299PhosphoserineBy similarity1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002155.
InParanoidiQ5RFI5.
KOiK01206.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiView protein in Pfam
PF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiView protein in SMART
SM00812. Alpha_L_fucos. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00385. ALPHA_L_FUCOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ
60 70 80 90 100
AKFGIFIHWG VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED
110 120 130 140 150
FGPLFTAKFF NANQWADIFQ ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA
160 170 180 190 200
IDEGPKRDIV KELEVAIRNR TDLRFGLYYS LFEWFHPLFL EDESSSFHKR
210 220 230 240 250
QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG FLAWLYNESP
260 270 280 290 300
VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW
310 320 330 340 350
GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER
360 370 380 390 400
LRQMGSWLKV NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW
410 420 430 440 450
PTSGQLFLGQ PKAILGATEV KLLGHGQPLN WISLERNGIM VELPQLTIHQ
460
MPCKWGWALA LTNVI
Length:465
Mass (Da):53,963
Last modified:December 21, 2004 - v1
Checksum:i820A0284528A8CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857171 mRNA. Translation: CAH89472.1.
RefSeqiNP_001127152.1. NM_001133680.2.
UniGeneiPab.7072.

Genome annotation databases

GeneIDi100174203.
KEGGipon:100174203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857171 mRNA. Translation: CAH89472.1.
RefSeqiNP_001127152.1. NM_001133680.2.
UniGeneiPab.7072.

3D structure databases

ProteinModelPortaliQ5RFI5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174203.
KEGGipon:100174203.

Organism-specific databases

CTDi2519.

Phylogenomic databases

HOVERGENiHBG002155.
InParanoidiQ5RFI5.
KOiK01206.

Enzyme and pathway databases

BRENDAi3.2.1.51. 9017.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiView protein in Pfam
PF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiView protein in SMART
SM00812. Alpha_L_fucos. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO2_PONAB
AccessioniPrimary (citable) accession number: Q5RFI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.