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Q5RFI5

- FUCO2_PONAB

UniProt

Q5RFI5 - FUCO2_PONAB

Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei292 – 2921May be important for catalysisPROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.51. 4967.

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase 2
    Short name:
    Alpha-L-fucosidase 2
    Gene namesi
    Name:FUCA2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 465439Plasma alpha-L-fucosidasePRO_0000010314Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RFI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG002155.
    InParanoidiQ5RFI5.
    KOiK01206.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR028756. FUCA2.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF24. PTHR10030:SF24. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RFI5-1 [UniParc]FASTAAdd to Basket

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    MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ    50
    AKFGIFIHWG VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED 100
    FGPLFTAKFF NANQWADIFQ ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA 150
    IDEGPKRDIV KELEVAIRNR TDLRFGLYYS LFEWFHPLFL EDESSSFHKR 200
    QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG FLAWLYNESP 250
    VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW 300
    GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER 350
    LRQMGSWLKV NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW 400
    PTSGQLFLGQ PKAILGATEV KLLGHGQPLN WISLERNGIM VELPQLTIHQ 450
    MPCKWGWALA LTNVI 465
    Length:465
    Mass (Da):53,963
    Last modified:December 21, 2004 - v1
    Checksum:i820A0284528A8CEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857171 mRNA. Translation: CAH89472.1.
    RefSeqiNP_001127152.1. NM_001133680.2.
    UniGeneiPab.7072.

    Genome annotation databases

    GeneIDi100174203.
    KEGGipon:100174203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857171 mRNA. Translation: CAH89472.1 .
    RefSeqi NP_001127152.1. NM_001133680.2.
    UniGenei Pab.7072.

    3D structure databases

    ProteinModelPortali Q5RFI5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174203.
    KEGGi pon:100174203.

    Organism-specific databases

    CTDi 2519.

    Phylogenomic databases

    HOVERGENi HBG002155.
    InParanoidi Q5RFI5.
    KOi K01206.

    Enzyme and pathway databases

    BRENDAi 3.2.1.51. 4967.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR028756. FUCA2.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF24. PTHR10030:SF24. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiFUCO2_PONAB
    AccessioniPrimary (citable) accession number: Q5RFI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3