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Q5RFI5

- FUCO2_PONAB

UniProt

Q5RFI5 - FUCO2_PONAB

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Protein
Plasma alpha-L-fucosidase
Gene
FUCA2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei292 – 2921May be important for catalysis By similarity

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. fucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 4967.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 465439Plasma alpha-L-fucosidase
PRO_0000010314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RFI5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002155.
InParanoidiQ5RFI5.
KOiK01206.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFI5-1 [UniParc]FASTAAdd to Basket

« Hide

MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ    50
AKFGIFIHWG VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED 100
FGPLFTAKFF NANQWADIFQ ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA 150
IDEGPKRDIV KELEVAIRNR TDLRFGLYYS LFEWFHPLFL EDESSSFHKR 200
QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG FLAWLYNESP 250
VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW 300
GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER 350
LRQMGSWLKV NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW 400
PTSGQLFLGQ PKAILGATEV KLLGHGQPLN WISLERNGIM VELPQLTIHQ 450
MPCKWGWALA LTNVI 465
Length:465
Mass (Da):53,963
Last modified:December 21, 2004 - v1
Checksum:i820A0284528A8CEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857171 mRNA. Translation: CAH89472.1.
RefSeqiNP_001127152.1. NM_001133680.2.
UniGeneiPab.7072.

Genome annotation databases

GeneIDi100174203.
KEGGipon:100174203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857171 mRNA. Translation: CAH89472.1 .
RefSeqi NP_001127152.1. NM_001133680.2.
UniGenei Pab.7072.

3D structure databases

ProteinModelPortali Q5RFI5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174203.
KEGGi pon:100174203.

Organism-specific databases

CTDi 2519.

Phylogenomic databases

HOVERGENi HBG002155.
InParanoidi Q5RFI5.
KOi K01206.

Enzyme and pathway databases

BRENDAi 3.2.1.51. 4967.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFUCO2_PONAB
AccessioniPrimary (citable) accession number: Q5RFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi