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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei292May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51 9017

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001031427 – 465Plasma alpha-L-fucosidaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei299PhosphoserineBy similarity1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFI5
SMRiQ5RFI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002155
InParanoidiQ5RFI5
KOiK01206

Family and domain databases

Gene3Di2.60.40.11801 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLP PPPCPAHSAT RFDPTWESLD ARQLPAWFDQ
60 70 80 90 100
AKFGIFIHWG VFSVPSFGSE WFWWYWQKEK IPKYVEFMKD NYPPSFKYED
110 120 130 140 150
FGPLFTAKFF NANQWADIFQ ASGAKYIVLT SKHHKGFTLW GSEYSWNWNA
160 170 180 190 200
IDEGPKRDIV KELEVAIRNR TDLRFGLYYS LFEWFHPLFL EDESSSFHKR
210 220 230 240 250
QFPVSKTLPE LYELVNNYQP EVLWSDGDGG APDQYWNSTG FLAWLYNESP
260 270 280 290 300
VRETVVTNDR WGAGSIYKHG GFYTCSDRYN PGHLLPHKWE NCMTIDKLSW
310 320 330 340 350
GYRREAGISD YLTIEELVKQ LVETVSCGGN LLMNIGPTLD GTISVVFEER
360 370 380 390 400
LRQMGSWLKV NGEAIYETHT WQSQNDTVTP DVWYTSKPKE KLVYAIFLKW
410 420 430 440 450
PTSGQLFLGQ PKAILGATEV KLLGHGQPLN WISLERNGIM VELPQLTIHQ
460
MPCKWGWALA LTNVI
Length:465
Mass (Da):53,963
Last modified:December 21, 2004 - v1
Checksum:i820A0284528A8CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857171 mRNA Translation: CAH89472.1
RefSeqiNP_001127152.1, NM_001133680.2
UniGeneiPab.7072

Genome annotation databases

GeneIDi100174203
KEGGipon:100174203

Similar proteinsi

Entry informationi

Entry nameiFUCO2_PONAB
AccessioniPrimary (citable) accession number: Q5RFI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome