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Q5RFH1

- TWF2_PONAB

UniProt

Q5RFH1 - TWF2_PONAB

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Protein

Twinfilin-2

Gene

TWF2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).By similarity

GO - Biological processi

  1. cell projection organization Source: UniProtKB-KW
  2. negative regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-2
Gene namesi
Name:TWF2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity. Cell projectionstereocilium By similarity
Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 341›341Twinfilin-2PRO_0000233138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61N6-acetyllysineBy similarity
Modified residuei301 – 3011PhosphotyrosineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on both serine and threonine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFH1.
SMRiQ5RFH1. Positions 1-129, 153-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 131›131ADF-H 1PROSITE-ProRule annotationAdd
BLAST
Domaini169 – 305137ADF-H 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ADF-H domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000848.
InParanoidiQ5RFH1.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5RFH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ATEELKEFFA KARAGSVRLI KVVIEDEQLV LGASQEPVGR WDRDYDRAVL
60 70 80 90 100
PLLDAQQPCY LLYRLDSQNA QGFEWLFLAW SPDNSPVRLK MLYAATRATV
110 120 130 140 150
KKEFGGGHIK DELFGTVKDD LSFAGYQKHL SSCAAPAPLT SAERELQQIR
160 170 180 190 200
INEVKTEISV ESKHQTLQGL AFPLQPEAQR ALQQLKQKMV NYIQMKLDLE
210 220 230 240 250
RETIELVHTE STDVAQLPSR VPRDAARYHF FLYKHTHEGD LLESVVFIYS
260 270 280 290 300
MPGYKCSIEE RMLYSSCKSR LLDSVEQDFH LEIAKKIEIG DGAELTAEFL
310 320 330 340
YDEVHPKQHA FKQAFAKPKG PGGKRGHKRL IRGPGENGDD S
Length:341
Mass (Da):38,707
Last modified:December 21, 2004 - v1
Checksum:i98C5E459EB3413A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857187 Transcribed RNA. Translation: CAH89486.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857187 Transcribed RNA. Translation: CAH89486.1 .

3D structure databases

ProteinModelPortali Q5RFH1.
SMRi Q5RFH1. Positions 1-129, 153-305.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000848.
InParanoidi Q5RFH1.

Family and domain databases

Gene3Di 3.40.20.10. 2 hits.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view ]
PANTHERi PTHR13759. PTHR13759. 1 hit.
Pfami PF00241. Cofilin_ADF. 2 hits.
[Graphical view ]
SMARTi SM00102. ADF. 2 hits.
[Graphical view ]
PROSITEi PS51263. ADF_H. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiTWF2_PONAB
AccessioniPrimary (citable) accession number: Q5RFH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3