Q5RFG3 (GPX3_PONPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase 3
Short name=GPx-3
Short name=GSHPx-3
EC=1.11.1.9

Alternative name(s):
Plasma glutathione peroxidase
Short name=GPx-P
Short name=GSHPx-P

Gene names

Name:

GPX3

Organism

Pongo pygmaeus (Bornean orangutan)

Taxonomic identifier

9600 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer By similarity.
Subcellular location	Secreted.
Tissue specificity	Secreted in plasma.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Selenocysteine
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological_process	protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	glutathione peroxidase activity Inferred from sequence or structural similarity. Source: UniProtKB selenium binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 226	202	Glutathione peroxidase 3		PRO_0000042615
Sites
	Active site	73	1	By similarity
Amino acid modifications
	Non-standard residue	73	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q5RFG3 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: D7F77A1692493D98	FASTA	226	25,562
	10 20 30 40 50 60 MARLLQASCL LSLLLAGFVP QSRGQEKSKM DCHGGISGTI YEYGALTIDG EEYIPFKQYA 70 80 90 100 110 120 GKYVLFVNVA SYUGLTGQYI ELNALQEELA PFGLVILGFP CNQFGKQEPG ENSEILPTLK 130 140 150 160 170 180 YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTS ELLGTSDRLF WEPMKVHDIR 190 200 210 220 WNFEKFLVGP DGIPIMRWHH RTTVSNVKMD ILSYMRRQAA LGVKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, gene expression, and evolution of primate glutathione peroxidases." Fukuhara R., Kageyama T. Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The German cDNA consortium Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB121006 mRNA. Translation: BAE17014.1. CR857195 mRNA. Translation: CAH89494.2.
UniGene	Pab.18214.
3D structure databases
ProteinModelPortal	Q5RFG3.
ModBase	Search...
Protein-protein interaction databases
STRING	9600.ENSPPYP00000017858.
Protein family/group databases
PeroxiBase	3727. PpyGPx03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0386.
HOGENOM	HOG000277055.
HOVERGEN	HBG004333.
InParanoid	Q5RFG3.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11592. PTHR11592. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX3_PONPY

Accession

Primary (citable) accession number: Q5RFG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 52 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program