Q5RFF5 (Q5RFF5_PONAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein DKFZp468G2216 EMBL CAH89502.1

Submitted name:
Uncharacterized protein Ensembl ENSPPYP00000022865

Gene names

Name:	DKFZp468G2216 EMBL CAH89502.1
Synonyms:	AR Ensembl ENSPPYP00000022865

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of prostate induction by androgen receptor signaling pathway Inferred from electronic annotation. Source: Compara epithelial cell differentiation involved in prostate gland development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara lateral sprouting involved in mammary gland duct morphogenesis Inferred from electronic annotation. Source: Compara male genitalia morphogenesis Inferred from electronic annotation. Source: Compara male gonad development Inferred from electronic annotation. Source: Compara male somatic sex determination Inferred from electronic annotation. Source: Compara mammary gland alveolus development Inferred from electronic annotation. Source: Compara morphogenesis of an epithelial fold Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of integrin biosynthetic process Inferred from electronic annotation. Source: Compara organ formation Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of insulin-like growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of integrin biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of intracellular estrogen receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase III promoter Inferred from electronic annotation. Source: Compara prostate gland epithelium morphogenesis Inferred from electronic annotation. Source: Compara prostate gland growth Inferred from electronic annotation. Source: Compara protein oligomerization Inferred from electronic annotation. Source: Compara regulation of catalytic activity Inferred from electronic annotation. Source: Compara regulation of developmental growth Inferred from electronic annotation. Source: Compara regulation of establishment of protein localization to plasma membrane Inferred from electronic annotation. Source: Compara regulation of prostatic bud formation Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara tertiary branching involved in mammary gland duct morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nuclear chromatin Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5RFF5 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 495BAE974B4EFC75	FASTA	388	44,643
	10 20 30 40 50 60 MILWLHSLET ARDHVLPIDY YFPPQKTCLI CGDEASGCHY GALTCGSCKV FFKRAAEGKQ 70 80 90 100 110 120 KYLCASRNDC TIDKFRRKNC PSCRLRKCYE AGMTLGARKL KKLGNLKLQE EGEASSTTSP 130 140 150 160 170 180 TEETTQKLTV SHIEGYECQP IFLNVLEAIE PGVVCAGHDN NQPDSFAALL SSLNELGERQ 190 200 210 220 230 240 LVHVVKWAKA LPGFRNLHVD DQMAVIQYSW MGLMVFAMGW RSFTNVNSRM LYFAPDLVFN 250 260 270 280 290 300 EYRMHKSRMY SQCVRMRHLS QEFGWLQITP QEFLCMKALL LFSIIPVDGL KNQKFFDELR 310 320 330 340 350 360 MNYIKELDRI IACKRKNPTS CSRRFYQLTK LLDSVQPIAR ELHQFTFDLL IKSHMVSVDF 370 380 PEMMAEIISV QVPKILSGKV KPIYFHTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The German cDNA Consortium Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL CAH89502.1.
[2]	"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome." Wilson R.K., Mardis E. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABGA01300586 Genomic DNA. No translation available. ABGA01300587 Genomic DNA. No translation available. ABGA01300588 Genomic DNA. No translation available. ABGA01300589 Genomic DNA. No translation available. ABGA01300590 Genomic DNA. No translation available. ABGA01300591 Genomic DNA. No translation available. ABGA01300592 Genomic DNA. No translation available. ABGA01300593 Genomic DNA. No translation available. ABGA01300594 Genomic DNA. No translation available. ABGA01300595 Genomic DNA. No translation available. ABGA01300596 Genomic DNA. No translation available. ABGA01300597 Genomic DNA. No translation available. ABGA01300598 Genomic DNA. No translation available. CR857203 mRNA. Translation: CAH89502.1.
RefSeq	NP_001124649.1. NM_001131177.2.
UniGene	Pab.9615.
3D structure databases
SMR	Q5RFF5. Positions 24-97, 138-387.
ModBase	Search...
Proteomic databases
PRIDE	Q5RFF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000023828; ENSPPYP00000022865; ENSPPYG00000020425.
GeneID	100171490.
KEGG	pon:100171490.
Organism-specific databases
CTD	367.
Phylogenomic databases
GeneTree	ENSGT00700000104072.
HOGENOM	HOG000037950.
HOVERGEN	HBG007583.
KO	K08557.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5RFF5_PONAB

Accession

Primary (citable) accession number: Q5RFF5

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)