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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041PROSITE-ProRule annotation
Active sitei388 – 3881PROSITE-ProRule annotation
Active sitei448 – 4481PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiponab-cpvl. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Gene namesi
Name:CPVL
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 476Probable serine carboxypeptidase CPVLPRO_0000004283
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – ?Sequence analysisPRO_0000004282

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019824.

Structurei

3D structure databases

ProteinModelPortaliQ5RFE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOVERGENiHBG010805.
InParanoidiQ5RFE4.
KOiK09645.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGTMWKVIV SLVLLMPGSC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE
60 70 80 90 100
AGKIQKGREL SLVSPFLGLN MRSYAGFLTV NKTYNSNLFF WFFPAQIQPE
110 120 130 140 150
DAPVVLWLQG GPGFSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY
160 170 180 190 200
IDNPVGTGFS FTDDTHGYAV NEDDVAQDLY SALIQFFQIF PEYKNNDFYV
210 220 230 240 250
TGESYAGKYV PAIAHLIHSL NPVREVKINL KGIAIGDGYS DPESIIGGYA
260 270 280 290 300
EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFQAFEIL DKLLDGDLTS
310 320 330 340 350
DPSYFQNVTG CSNYCNFLRC TEPEDQLYYA KFLSLPEVRQ AIHVGNRTFN
360 370 380 390 400
DGTTVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTEHSL
410 420 430 440 450
MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YVRQVGDFHQ VIIRGGGHIL
460 470
PYIQPLRAFD MINRFIYGKG WDPYVG
Length:476
Mass (Da):54,254
Last modified:December 21, 2004 - v1
Checksum:iF05307D75BE88C63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857214 mRNA. Translation: CAH89513.1.
RefSeqiNP_001124656.1. NM_001131184.1.

Genome annotation databases

GeneIDi100171497.
KEGGipon:100171497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857214 mRNA. Translation: CAH89513.1.
RefSeqiNP_001124656.1. NM_001131184.1.

3D structure databases

ProteinModelPortaliQ5RFE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019824.

Protein family/group databases

ESTHERiponab-cpvl. Carboxypeptidase_S10.
MEROPSiS10.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100171497.
KEGGipon:100171497.

Organism-specific databases

CTDi54504.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOVERGENiHBG010805.
InParanoidiQ5RFE4.
KOiK09645.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPVL_PONAB
AccessioniPrimary (citable) accession number: Q5RFE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.