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Protein

Aminoacylase-1

Gene

ACY1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).By similarity

Catalytic activityi

An N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate.
An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Zinc 1By similarity1
Active sitei82By similarity1
Metal bindingi113Zinc 1By similarity1
Metal bindingi113Zinc 2By similarity1
Active sitei147Proton acceptorBy similarity1
Metal bindingi148Zinc 2By similarity1
Metal bindingi175Zinc 1By similarity1
Metal bindingi373Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoacylase-1 (EC:3.5.1.14)
Short name:
ACY-1
Alternative name(s):
N-acyl-L-amino-acid amidohydrolase
Gene namesi
Name:ACY1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740081 – 408Aminoacylase-1Add BLAST408

Interactioni

Subunit structurei

Homodimer. Interacts with SPHK1.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015464.

Structurei

3D structure databases

ProteinModelPortaliQ5RFB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2275. Eukaryota.
COG0624. LUCA.
HOVERGENiHBG000982.
InParanoidiQ5RFB0.
KOiK14677.

Family and domain databases

CDDicd05646. M20_AcylaseI_like. 1 hit.
InterProiView protein in InterPro
IPR001261. ArgE/DapE_CS.
IPR036264. Bact_exopeptidase_dim_dom.
IPR010159. N-acyl_aa_amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
PfamiView protein in Pfam
PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01880. Ac-peptdase-euk. 1 hit.
PROSITEiView protein in PROSITE
PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RFB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE RARQLGLGCQ
60 70 80 90 100
KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK
110 120 130 140 150
DSEGYIYARG AQDMKCISIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG
160 170 180 190 200
GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS
210 220 230 240 250
TGRPGHASRF MEDTAAEKLH KVVSSILAFR EKEWQRLQSN PHLKEGSVTS
260 270 280 290 300
VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG
310 320 330 340 350
VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMKLTLEP EIMPAATDNR
360 370 380 390 400
YIRAVGIPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS

VPALPSES
Length:408
Mass (Da):45,969
Last modified:January 23, 2007 - v2
Checksum:iDA5F3D6468261C84
GO

Sequence cautioni

Q5RFB0: The sequence CAH89547 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857251 mRNA. Translation: CAH89547.1. Different initiation.
RefSeqiNP_001124673.1. NM_001131201.2.

Genome annotation databases

GeneIDi100171519.
KEGGipon:100171519.

Similar proteinsi

Entry informationi

Entry nameiACY1_PONAB
AccessioniPrimary (citable) accession number: Q5RFB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families