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Q5RFB0

- ACY1_PONAB

UniProt

Q5RFB0 - ACY1_PONAB

Protein

Aminoacylase-1

Gene

ACY1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).By similarity

    Catalytic activityi

    An N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate.
    An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Zinc 1By similarity
    Active sitei82 – 821By similarity
    Metal bindingi113 – 1131Zinc 1By similarity
    Metal bindingi113 – 1131Zinc 2By similarity
    Active sitei147 – 1471Proton acceptorBy similarity
    Metal bindingi148 – 1481Zinc 2By similarity
    Metal bindingi175 – 1751Zinc 1By similarity
    Metal bindingi373 – 3731Zinc 2By similarity

    GO - Molecular functioni

    1. aminoacylase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. metallopeptidase activity Source: InterPro

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoacylase-1 (EC:3.5.1.14)
    Short name:
    ACY-1
    Alternative name(s):
    N-acyl-L-amino-acid amidohydrolase
    Gene namesi
    Name:ACY1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 408407Aminoacylase-1PRO_0000274008Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SPHK1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RFB0.
    SMRiQ5RFB0. Positions 7-198, 321-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20A family.Curated

    Phylogenomic databases

    HOVERGENiHBG000982.
    InParanoidiQ5RFB0.
    KOiK14677.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR010159. N-acyl_aa_amidohydrolase.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036696. ACY-1. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01880. Ac-peptdase-euk. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RFB0-1 [UniParc]FASTAAdd to Basket

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    MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE RARQLGLGCQ    50
    KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK 100
    DSEGYIYARG AQDMKCISIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG 150
    GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS 200
    TGRPGHASRF MEDTAAEKLH KVVSSILAFR EKEWQRLQSN PHLKEGSVTS 250
    VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG 300
    VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMKLTLEP EIMPAATDNR 350
    YIRAVGIPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS 400
    VPALPSES 408
    Length:408
    Mass (Da):45,969
    Last modified:January 23, 2007 - v2
    Checksum:iDA5F3D6468261C84
    GO

    Sequence cautioni

    The sequence CAH89547.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857251 mRNA. Translation: CAH89547.1. Different initiation.
    RefSeqiNP_001124673.1. NM_001131201.2.

    Genome annotation databases

    GeneIDi100171519.
    KEGGipon:100171519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857251 mRNA. Translation: CAH89547.1 . Different initiation.
    RefSeqi NP_001124673.1. NM_001131201.2.

    3D structure databases

    ProteinModelPortali Q5RFB0.
    SMRi Q5RFB0. Positions 7-198, 321-408.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100171519.
    KEGGi pon:100171519.

    Organism-specific databases

    CTDi 95.

    Phylogenomic databases

    HOVERGENi HBG000982.
    InParanoidi Q5RFB0.
    KOi K14677.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR010159. N-acyl_aa_amidohydrolase.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036696. ACY-1. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01880. Ac-peptdase-euk. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiACY1_PONAB
    AccessioniPrimary (citable) accession number: Q5RFB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3