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Q5RFA6

- ALDOB_PONAB

UniProt

Q5RFA6 - ALDOB_PONAB

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Protein
Fructose-bisphosphate aldolase B
Gene
ALDOB
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate By similarity
Binding sitei147 – 1471Substrate By similarity
Active sitei188 – 1881Proton acceptor By similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 364363Fructose-bisphosphate aldolase B
PRO_0000230296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei13 – 131N6-succinyllysine By similarity
Modified residuei36 – 361Phosphoserine By similarity
Modified residuei39 – 391Phosphothreonine By similarity
Modified residuei121 – 1211N6-succinyllysine By similarity
Modified residuei317 – 3171N6-succinyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with BBS1, BBS2, BBS4 and BBS7 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RFA6.
SMRiQ5RFA6. Positions 2-361.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.
InParanoidiQ5RFA6.
KOiK01623.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFA6-1 [UniParc]FASTAAdd to Basket

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MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE    50
NTEENRRQFR EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE 100
KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA 150
VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VIPDGDHDLE 200
HCQYVTEKVL AAAYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA 250
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF 300
SYGRALQASA LAAWGGKAAN KEATQEAFMK RAVANHQAAK GQYVHTGSSG 350
AASTQSLFTA CYTY 364
Length:364
Mass (Da):39,447
Last modified:January 23, 2007 - v3
Checksum:i992D2580A7F34CB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857255 mRNA. Translation: CAH89551.1.
RefSeqiNP_001127166.1. NM_001133694.1.

Genome annotation databases

GeneIDi100174217.
KEGGipon:100174217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857255 mRNA. Translation: CAH89551.1 .
RefSeqi NP_001127166.1. NM_001133694.1.

3D structure databases

ProteinModelPortali Q5RFA6.
SMRi Q5RFA6. Positions 2-361.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174217.
KEGGi pon:100174217.

Organism-specific databases

CTDi 229.

Phylogenomic databases

HOVERGENi HBG002386.
InParanoidi Q5RFA6.
KOi K01623.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiALDOB_PONAB
AccessioniPrimary (citable) accession number: Q5RFA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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