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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (CR201_G0049051), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (CR201_G0049051), Glucose-6-phosphate isomerase (CR201_G0049051), Glucose-6-phosphate isomerase (GPI)
  3. ATP-dependent 6-phosphofructokinase (CR201_G0011728), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), 6-phosphofructokinase (CR201_G0048952), ATP-dependent 6-phosphofructokinase (CR201_G0048952), ATP-dependent 6-phosphofructokinase (CR201_G0011728), ATP-dependent 6-phosphofructokinase (DKFZp468O105), ATP-dependent 6-phosphofructokinase (CR201_G0046679), ATP-dependent 6-phosphofructokinase (CR201_G0011728)
  4. Fructose-bisphosphate aldolase (CR201_G0034412), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (CR201_G0033506), Fructose-bisphosphate aldolase (CR201_G0033506), Fructose-bisphosphate aldolase (CR201_G0008177), Fructose-bisphosphate aldolase (CR201_G0034412), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase (CR201_G0034412), Fructose-bisphosphate aldolase (CR201_G0034412), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002302962 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13N6-succinyllysineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121N6-succinyllysineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei317N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5RFA6

Interactioni

Subunit structurei

Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021797

Structurei

3D structure databases

ProteinModelPortaliQ5RFA6
SMRiQ5RFA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
HOVERGENiHBG002386
InParanoidiQ5RFA6
KOiK01623

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE
60 70 80 90 100
NTEENRRQFR EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE
110 120 130 140 150
KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA
160 170 180 190 200
VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VIPDGDHDLE
210 220 230 240 250
HCQYVTEKVL AAAYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA
260 270 280 290 300
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF
310 320 330 340 350
SYGRALQASA LAAWGGKAAN KEATQEAFMK RAVANHQAAK GQYVHTGSSG
360
AASTQSLFTA CYTY
Length:364
Mass (Da):39,447
Last modified:January 23, 2007 - v3
Checksum:i992D2580A7F34CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857255 mRNA Translation: CAH89551.1
RefSeqiNP_001127166.1, NM_001133694.1

Genome annotation databases

GeneIDi100174217
KEGGipon:100174217

Similar proteinsi

Entry informationi

Entry nameiALDOB_PONAB
AccessioniPrimary (citable) accession number: Q5RFA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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