Q5RF87 (SPS1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenide, water dikinase 1
EC=2.7.9.3

Alternative name(s):
Selenium donor protein 1
Selenophosphate synthase 1

Gene names

Name:

SEPHS1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the selenophosphate synthase 1 family. Class II subfamily.
Caution	The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding Selenium
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Selenide, water dikinase 1		PRO_0000312507
Regions
	Nucleotide binding	67 – 69	3	ATP By similarity
	Nucleotide binding	162 – 164	3	ATP; shared with dimeric partner By similarity
	Nucleotide binding	267 – 273	7	ATP By similarity
Sites
	Active site	31	1	Potential
	Binding site	32	1	ATP By similarity
	Binding site	87	1	ATP By similarity
	Binding site	110	1	ATP By similarity
	Site	32	1	Important for catalytic activity By similarity
Amino acid modifications
	Modified residue	392	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RF87 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: E9636E38146D926D	FASTA	392	42,911
	10 20 30 40 50 60 MSTRESFNPE SYELDKSFRL TRFTELKGTG CKVPQDVLQK LLESLQENHF QEDEQFLGAV 70 80 90 100 110 120 MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD 130 140 150 160 170 180 NMLMLLGVSN KMTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWI VLGGVATTVC 190 200 210 220 230 240 QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA 250 260 270 280 290 300 MMNMARLNRT AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA 310 320 330 340 350 360 AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG 370 380 390 NRTARIIDKP RIIEVAPQVA TQNVNPTPGA TS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857274 mRNA. Translation: CAH89570.1.
RefSeq	NP_001124690.1. NM_001131218.1.
UniGene	Pab.9275.
3D structure databases
ProteinModelPortal	Q5RF87.
SMR	Q5RF87. Positions 6-377.
ModBase	Search...
Proteomic databases
PRIDE	Q5RF87.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000002511; ENSPPYP00000002437; ENSPPYG00000002099.
GeneID	100171537.
KEGG	pon:100171537.
Organism-specific databases
CTD	22929.
Phylogenomic databases
HOVERGEN	HBG001207.
InParanoid	Q5RF87.
OMA	MMAIAIL.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. [Graphical view]
KO	K01008.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00476. SelD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPS1_PONAB

Accession

Primary (citable) accession number: Q5RF87

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 21, 2004
Last modified:	November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program