SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5RF65

- GBA3_PONAB

UniProt

Q5RF65 - GBA3_PONAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytosolic beta-glucosidase

Gene
GBA3, CBG
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Active sitei165 – 1651Proton donor Reviewed prediction
Binding sitei309 – 3091Substrate By similarity
Active sitei373 – 3731Nucleophile Reviewed prediction
Binding sitei417 – 4171Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB
  2. beta-glucosidase activity Source: UniProtKB
  3. glycosylceramidase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycosylceramide catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic beta-glucosidase (EC:3.2.1.21)
Gene namesi
Name:GBA3
Synonyms:CBG
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 4

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Cytosolic beta-glucosidasePRO_0000063909Add
BLAST

Post-translational modificationi

The N-terminus is blocked By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RF65.
SMRiQ5RF65. Positions 1-466.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni424 – 4252Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074452.
HOVERGENiHBG053101.
InParanoidiQ5RF65.
KOiK05350.
OMAiALMSKKQ.
OrthoDBiEOG7MH0XV.
TreeFamiTF314803.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RF65-1 [UniParc]FASTAAdd to Basket

« Hide

MAFPVGFGWA AATAAYQVEG GWDADGKGPC VWDTFTHQGG ERVFKNQTGD    50
VACGSYTLWE EDLKCIKQLG LTHYRFSLSW SRLLPDGTTG FINQKGIDYY 100
NKIIDDLLKN GVTPIVTLYH FDLPQALEDQ GGWLSEAIIE SFDKYAQFCF 150
STFGDRVKKW ITINEANVLS VMSYDLGMFP PGIPHFGTGG YQAAHNLIKA 200
HARSWHSYNS LFRKEQKGMV SLSLFAVWLE PADPNSVSDQ EAAKRAITFH 250
LDLFAKPIFI DGDYPEIVKS QIASMSQKQG YPSSRLPEFT EEEKKMIKGT 300
ADFFAVQYYT TRLIKYQENK KGELGILQDA EIEFFPDPSW KNVDWIYVVP 350
WGVRKLLKYI KDTYNNPVIY ITENGFPQSD PAPLDDTQRW EYFRQTFQEL 400
FKAIQLDKVN LQVYCAWSLL DNFEWNQGYS SRFGLFHVDF EDPARPRVPY 450
TSAKEYAKVI RNNGLEAHL 469
Length:469
Mass (Da):53,747
Last modified:December 21, 2004 - v1
Checksum:iEC6DFA9543EA6843
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857296 mRNA. Translation: CAH89592.1.
RefSeqiNP_001124705.1. NM_001131233.1.

Genome annotation databases

EnsembliENSPPYT00000017020; ENSPPYP00000016355; ENSPPYG00000014639.
GeneIDi100171553.
KEGGipon:100171553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857296 mRNA. Translation: CAH89592.1 .
RefSeqi NP_001124705.1. NM_001131233.1.

3D structure databases

ProteinModelPortali Q5RF65.
SMRi Q5RF65. Positions 1-466.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000017020 ; ENSPPYP00000016355 ; ENSPPYG00000014639 .
GeneIDi 100171553.
KEGGi pon:100171553.

Organism-specific databases

CTDi 57733.

Phylogenomic databases

GeneTreei ENSGT00550000074452.
HOVERGENi HBG053101.
InParanoidi Q5RF65.
KOi K05350.
OMAi ALMSKKQ.
OrthoDBi EOG7MH0XV.
TreeFami TF314803.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGBA3_PONAB
AccessioniPrimary (citable) accession number: Q5RF65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: December 21, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi