Reviewed, UniProtKB/Swiss-Prot Q5RF60 (AL3A2_PONAB)

Names and origin

Protein names

Recommended name:
    Fatty aldehyde dehydrogenase
    EC=1.2.1.3
Alternative name(s):
    Aldehyde dehydrogenase family 3 member A2

Gene names

Name:

ALDH3A2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic sideBy similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Fatty aldehyde dehydrogenase		PRO_0000342181
Regions
	Topological domain	1 – 463	463	Cytoplasmic
	Transmembrane	464 – 480	17	Potential
	Nucleotide binding	185 – 190	6	NAD Potential
	Motif	481 – 484	4	Prevents secretion from ER By similarity
Sites
	Active site	207	1	By similarity
	Active site	241	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RF60-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 2DBB29DC3074C3BC	FASTA	485	54,866
	10 20 30 40 50 60 MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLC KSEFNVYSQE 70 80 90 100 110 120 VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ 130 140 150 160 170 180 PLIGAIAAGN AVIIKPSELS ENTAKMLAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH 190 200 210 220 230 240 IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 250 260 270 280 290 300 CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 310 320 330 340 350 360 AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA 370 380 390 400 410 420 LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFMLNSFPFG GVGSSGMGAY HGKHSFDTFS 430 440 450 460 470 480 HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV KAEYY

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857301 mRNA. Translation: CAH89597.1.
RefSeq	NP_001124709.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100171557.
Phylogenomic databases
HOVERGEN	Q5RF60.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR012394. Ald_DHase_NAD(P). IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL3A2_PONAB

Accession

Primary (citable) accession number: Q5RF60

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)