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Q5RF32 (BHMT2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine--homocysteine S-methyltransferase 2

EC=2.1.1.5
Gene names
Name:BHMT2
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline By similarity.

Catalytic activity

Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Contains 1 Hcy-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Betaine--homocysteine S-methyltransferase 2
PRO_0000273226

Regions

Domain11 – 305295Hcy-binding

Sites

Metal binding2081Zinc By similarity
Metal binding2901Zinc By similarity
Metal binding2911Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RF32 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D2B34B3F8EF4A103

FASTA36340,336
        10         20         30         40         50         60 
MAPAGHPGAK RGILERLESG EVVIGDGSFL ITLEKRGYVK AGLWTPEAVI EHPDAVRQLH 

        70         80         90        100        110        120 
MEFLRAGSNV MQTFTFSASE DNMESKWEDV NAAACDLARE VAGKGDALVA GGICQTSIYK 

       130        140        150        160        170        180 
YHKDEARIKK LFRQQLEVFA WKNVDFLIAE YFEHVEEAVW AVEVLKESDR PVAVTMCISP 

       190        200        210        220        230        240 
EGDMHDITPG ECAVRLVKAG ASIVGVNCRF GPETSLKTIE LMKEGLQRAG LKAHLMVQPL 

       250        260        270        280        290        300 
GFHTPDCGKE GFVDLPEYPF GLESRAATRW DIQKYAREAY NQGVRYIGGC CGFEPYHIRA 

       310        320        330        340        350        360 
IAEELAPERG FLPPASEKHG SWGSALDMHT KPWVRARARR EYWENLLPAS GRPFCPSLSK 


PDV 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857329 mRNA. Translation: CAH89625.1.
RefSeqNP_001127177.1. NM_001133705.1.
UniGenePab.19464.

3D structure databases

HSSPHSSP built from PDB template 1LT7 based on UniProtKB Q93088.
ProteinModelPortalQ5RF32.
SMRQ5RF32. Positions 10-362.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000018128; ENSPPYP00000017422; ENSPPYG00000015585.
GeneID100174229.
KEGGpon:100174229.

Organism-specific databases

CTD23743.

Phylogenomic databases

HOVERGENHBG080367.
InParanoidQ5RF32.
OMAKGGFVDL.
OrthoDBEOG4001JM.

Family and domain databases

InterProIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
Gene3DG3DSA:3.20.20.330. S_methyl_trans. 1 hit.
PfamPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMSSF82282. S_methyl_trans. 1 hit.
PROSITEPS50970. HCY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBHMT2_PONAB
AccessionPrimary (citable) accession number: Q5RF32
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: June 28, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families