Reviewed, UniProtKB/Swiss-Prot Q5RF10 (CATA_PONAB)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:

CAT

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group By similarity. NADP By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding NADP
Molecular function	Mitogen Oxidoreductase Peroxidase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 527	526	Catalase		PRO_0000084904
Sites
	Active site	75	1	By similarity
	Active site	148	1	By similarity
	Metal binding	358	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	231	1	Phosphotyrosine By similarity
	Modified residue	308	1	Phosphotyrosine By similarity
	Modified residue	422	1	Phosphoserine By similarity
	Modified residue	517	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RF10-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 96E1156BFBBC8970	FASTA	527	59,720
	10 20 30 40 50 60 MADSRDPASD QMKHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE 70 80 90 100 110 120 MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES 130 140 150 160 170 180 GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPLL FPSFIHSQKR NPQTHLKDPD 190 200 210 220 230 240 MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ 250 260 270 280 290 300 GIKNLSVEDA ARLSQEDPDY GIRDLFNAIA TEKYPSWTFY IQVMTFNQAE TFPFNPFDLT 310 320 330 340 350 360 KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFAYPD 370 380 390 400 410 420 THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEQQPSALE 430 440 450 460 470 480 HSTQCSGEVQ RFNTASDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK 490 500 510 520 NFTEVHPDYG SRIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857351 mRNA. Translation: CAH89647.1.
RefSeq	NP_001124739.1.
UniGene	Pab.18299
3D structure databases
SMR	Q5RF10. Positions 24-504.
ModBase	Search...
Protein family/group databases
PeroxiBase	6421. PabeKat01.
Genome annotation databases
GeneID	100171588.
Organism-specific databases
CTD	100171588.
Phylogenomic databases
HOVERGEN	Q5RF10.
InParanoid	Q5RF10.
OMA	PVNCPFR.
Enzyme and pathway databases
BRENDA	1.11.1.6. 269192.
Family and domain databases
InterPro	IPR002226. Catalase. IPR020835. Catalase-like_haem-dep. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_PONAB

Accession

Primary (citable) accession number: Q5RF10

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 44 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)