Reviewed, UniProtKB/Swiss-Prot Q5RF05 (HGD_PONAB)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisic acid oxidase
    Homogentisate oxygenase
    Homogentisicase

Gene names

Name:

HGD

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Homogentisate 1,2-dioxygenase		PRO_0000314969
Sites
	Metal binding	335	1	Iron By similarity
	Metal binding	341	1	Iron By similarity
	Metal binding	371	1	Iron By similarity
Amino acid modifications
	Modified residue	98	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RF05-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 2A7475FF04FC3A43	FASTA	445	49,911
	10 20 30 40 50 60 MAQLKYISGF GNECSSEDPR CPGSLPEGQN NPQVCPYNLY AEQLSGSAFT CPRSTNKRSW 70 80 90 100 110 120 LYRIPPSVSH KPFESIDEGH VTHNWDEVDP DPNQLRWKPF EIPKVSQKKV DLVSGLHTLC 130 140 150 160 170 180 GAGDIKSNNG LAIHIFLCNT SMENRCFYNS DGDFLIVPQK GNLLIYTEFG KMLVQPNEIC 190 200 210 220 230 240 VIQRGMRFSI DVFEETRGYI LEVYGVHFEL PDLGPIGANG LANPRDFLIP VAWYEDRQVP 250 260 270 280 290 300 GGYTVIDKYQ GKLFAAKQGV SPFNVVAWHG NYTPYKYNLK NFMVINSVAF DHADPSIFTV 310 320 330 340 350 360 LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIRGHY EAKQGGFLPG 370 380 390 400 410 420 GGSLHSTMTP HGPDADCFEK ASKAKLAPER IADGTMAFMF ESSLSLAVTK WGLKASRCLD 430 440 ENYHKCWEPL KSHFTPNFRN PAEPN

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857357 mRNA. Translation: CAH89652.1.
RefSeq	NP_001124743.1.
UniGene	Pab.7136
3D structure databases
HSSP	HSSP built from PDB template 1EYB based on UniProtKB Q93099.
SMR	Q5RF05. Positions 2-440.
ModBase	Search...
Genome annotation databases
GeneID	100171592.
Organism-specific databases
CTD	100171592.
Phylogenomic databases
HOVERGEN	Q5RF05.
InParanoid	Q5RF05.
Enzyme and pathway databases
BRENDA	1.13.11.5. 269192.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_PONAB

Accession

Primary (citable) accession number: Q5RF05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 21, 2004
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)