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Reviewed, UniProtKB/Swiss-Prot Q5RF05 (HGD_PONAB)

Last modified February 9, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisic acid oxidase
    Homogentisate oxygenase
    Homogentisicase
Gene names
Name: HGD
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactor

Iron By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Homogentisate 1,2-dioxygenase
PRO_0000314969

Sites

Metal binding3351Iron By similarity
Metal binding3411Iron By similarity
Metal binding3711Iron By similarity

Amino acid modifications

Modified residue981N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RF05-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 2A7475FF04FC3A43

FASTA44549,911
        10         20         30         40         50         60 
MAQLKYISGF GNECSSEDPR CPGSLPEGQN NPQVCPYNLY AEQLSGSAFT CPRSTNKRSW 

        70         80         90        100        110        120 
LYRIPPSVSH KPFESIDEGH VTHNWDEVDP DPNQLRWKPF EIPKVSQKKV DLVSGLHTLC 

       130        140        150        160        170        180 
GAGDIKSNNG LAIHIFLCNT SMENRCFYNS DGDFLIVPQK GNLLIYTEFG KMLVQPNEIC 

       190        200        210        220        230        240 
VIQRGMRFSI DVFEETRGYI LEVYGVHFEL PDLGPIGANG LANPRDFLIP VAWYEDRQVP 

       250        260        270        280        290        300 
GGYTVIDKYQ GKLFAAKQGV SPFNVVAWHG NYTPYKYNLK NFMVINSVAF DHADPSIFTV 

       310        320        330        340        350        360 
LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIRGHY EAKQGGFLPG 

       370        380        390        400        410        420 
GGSLHSTMTP HGPDADCFEK ASKAKLAPER IADGTMAFMF ESSLSLAVTK WGLKASRCLD 

       430        440 
ENYHKCWEPL KSHFTPNFRN PAEPN 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857357 mRNA. Translation: CAH89652.1.
RefSeqNP_001124743.1.
UniGenePab.7136

3D structure databases

HSSPHSSP built from PDB template 1EYB based on UniProtKB Q93099.
SMRQ5RF05. Positions 2-440.
ModBaseSearch...

Genome annotation databases

GeneID100171592.

Organism-specific databases

CTD100171592.

Phylogenomic databases

HOVERGENQ5RF05.
InParanoidQ5RF05.

Enzyme and pathway databases

BRENDA1.13.11.5. 269192.

Family and domain databases

InterProIPR011051. Cupin_RmlC_type.
IPR005708. Homogentis_dOase.
[Graphical view]
PANTHERPTHR11056. Homogentis_dOase. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_PONAB
AccessionPrimary (citable) accession number: Q5RF05
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents