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Q5RF05

- HGD_PONAB

UniProt

Q5RF05 - HGD_PONAB

Protein

Homogentisate 1,2-dioxygenase

Gene

HGD

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi335 – 3351IronBy similarity
    Metal bindingi341 – 3411IronBy similarity
    Metal bindingi371 – 3711IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    2. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:HGD
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Homogentisate 1,2-dioxygenasePRO_0000314969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei98 – 981N6-acetyllysineBy similarity
    Modified residuei414 – 4141N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Homohexamer arranged as a dimer of trimers.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RF05.
    SMRiQ5RF05. Positions 2-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000139824.
    HOVERGENiHBG005965.
    InParanoidiQ5RF05.
    KOiK00451.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5RF05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLKYISGF GNECSSEDPR CPGSLPEGQN NPQVCPYNLY AEQLSGSAFT    50
    CPRSTNKRSW LYRIPPSVSH KPFESIDEGH VTHNWDEVDP DPNQLRWKPF 100
    EIPKVSQKKV DLVSGLHTLC GAGDIKSNNG LAIHIFLCNT SMENRCFYNS 150
    DGDFLIVPQK GNLLIYTEFG KMLVQPNEIC VIQRGMRFSI DVFEETRGYI 200
    LEVYGVHFEL PDLGPIGANG LANPRDFLIP VAWYEDRQVP GGYTVIDKYQ 250
    GKLFAAKQGV SPFNVVAWHG NYTPYKYNLK NFMVINSVAF DHADPSIFTV 300
    LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIRGHY 350
    EAKQGGFLPG GGSLHSTMTP HGPDADCFEK ASKAKLAPER IADGTMAFMF 400
    ESSLSLAVTK WGLKASRCLD ENYHKCWEPL KSHFTPNFRN PAEPN 445
    Length:445
    Mass (Da):49,911
    Last modified:December 21, 2004 - v1
    Checksum:i2A7475FF04FC3A43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857357 mRNA. Translation: CAH89652.1.
    RefSeqiNP_001124743.1. NM_001131271.2.
    UniGeneiPab.7136.

    Genome annotation databases

    GeneIDi100171592.
    KEGGipon:100171592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857357 mRNA. Translation: CAH89652.1 .
    RefSeqi NP_001124743.1. NM_001131271.2.
    UniGenei Pab.7136.

    3D structure databases

    ProteinModelPortali Q5RF05.
    SMRi Q5RF05. Positions 2-440.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100171592.
    KEGGi pon:100171592.

    Organism-specific databases

    CTDi 3081.

    Phylogenomic databases

    HOGENOMi HOG000139824.
    HOVERGENi HBG005965.
    InParanoidi Q5RF05.
    KOi K00451.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHGD_PONAB
    AccessioniPrimary (citable) accession number: Q5RF05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3