Reviewed, UniProtKB/Swiss-Prot Q5RF00 (ALDH2_PONAB)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase, mitochondrial
    EC=1.2.1.3
Alternative name(s):
    ALDH class 2
    ALDH-E2

Gene names

Name:

ALDH2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Is capable of converting retinaldehyde to retinoic acid By similarity.
Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrixBy similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 17	17	Mitochondrion By similarity
	Chain	18 – 517	500	Aldehyde dehydrogenase, mitochondrial		PRO_0000312493
Regions
	Nucleotide binding	262 – 267	6	NAD By similarity
Sites
	Active site	285	1	Proton acceptor By similarity
	Active site	319	1	Nucleophile By similarity
	Site	186	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	18	1	N-acetylserine By similarity
	Modified residue	368	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RF00-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: E8F74D4CFA27220E	FASTA	517	56,380
	10 20 30 40 50 60 MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS 70 80 90 100 110 120 TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA 130 140 150 160 170 180 ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG 190 200 210 220 230 240 QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG 250 260 270 280 290 300 FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM 310 320 330 340 350 360 DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP 370 380 390 400 410 420 QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP TVFGDVQDGM TIAKEEIFGP 430 440 450 460 470 480 VMQILKFKTI EEVVGRANNS TYGLAAAVFT KDLDKANYLS QALQAGTVWV NCYNVFGAQS 490 500 510 PFGGYKMSGS GRELGEYGLQ AYTEVKTVTV KVPQKNS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857362 mRNA. Translation: CAH89657.1.
RefSeq	NP_001124747.1.
3D structure databases
SMR	Q5RF00. Positions 24-517.
ModBase	Search...
Genome annotation databases
GeneID	100171596.
Phylogenomic databases
HOVERGEN	Q5RF00.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_PONAB

Accession

Primary (citable) accession number: Q5RF00

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 21, 2004
Last modified:	November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)