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Protein

Inositol oxygenase

Gene

MIOX

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway: myo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Inositol oxygenase (MIOX)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291SubstrateBy similarity
Metal bindingi98 – 981Iron 1By similarity
Metal bindingi123 – 1231Iron 1By similarity
Metal bindingi124 – 1241Iron 1By similarity
Metal bindingi124 – 1241Iron 2By similarity
Binding sitei127 – 1271SubstrateBy similarity
Metal bindingi194 – 1941Iron 2By similarity
Metal bindingi220 – 2201Iron 2By similarity
Metal bindingi253 – 2531Iron 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:MIOX
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Inositol oxygenasePRO_0000079151Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013373.

Structurei

3D structure databases

ProteinModelPortaliQ5REY9.
SMRiQ5REY9. Positions 28-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 873Substrate bindingBy similarity
Regioni141 – 1422Substrate bindingBy similarity
Regioni220 – 2212Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016211.
HOVERGENiHBG039556.
InParanoidiQ5REY9.
KOiK00469.
OMAiPEAFYMI.
OrthoDBiEOG7DZ8KD.
TreeFamiTF300089.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5REY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVGPDPS LVYRPDVDPE MAKDKASFRN YTSGPLLDRV FTTYKLMHTH
60 70 80 90 100
QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF
110 120 130 140 150
QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP
160 170 180 190 200
QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ
210 220 230 240 250
VMKFNKFSLP PEAFYMIRFH SFYPWHTGSD YQQLCSQQDL AMLPWVQEFN
260 270 280
KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW
Length:285
Mass (Da):32,944
Last modified:December 21, 2004 - v1
Checksum:iD4481A96F29069D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857374 mRNA. Translation: CAH89668.1.
RefSeqiNP_001124754.1. NM_001131282.2.

Genome annotation databases

EnsembliENSPPYT00000013919; ENSPPYP00000013373; ENSPPYG00000011988.
GeneIDi100171604.
KEGGipon:100171604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857374 mRNA. Translation: CAH89668.1.
RefSeqiNP_001124754.1. NM_001131282.2.

3D structure databases

ProteinModelPortaliQ5REY9.
SMRiQ5REY9. Positions 28-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000013919; ENSPPYP00000013373; ENSPPYG00000011988.
GeneIDi100171604.
KEGGipon:100171604.

Organism-specific databases

CTDi55586.

Phylogenomic databases

GeneTreeiENSGT00390000016211.
HOVERGENiHBG039556.
InParanoidiQ5REY9.
KOiK00469.
OMAiPEAFYMI.
OrthoDBiEOG7DZ8KD.
TreeFamiTF300089.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMIOX_PONAB
AccessioniPrimary (citable) accession number: Q5REY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.