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Q5REY9 (MIOX_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Myo-inositol oxygenase
Short name=MI oxygenase
Gene names
Name:MIOX
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Inositol oxygenase
PRO_0000079151

Regions

Region85 – 873Substrate binding By similarity
Region141 – 1422Substrate binding By similarity
Region220 – 2212Substrate binding By similarity

Sites

Metal binding981Iron 1 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1941Iron 2 By similarity
Metal binding2201Iron 2 By similarity
Metal binding2531Iron 1 By similarity
Binding site291Substrate By similarity
Binding site1271Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5REY9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D4481A96F29069D6

FASTA28532,944
        10         20         30         40         50         60 
MKVTVGPDPS LVYRPDVDPE MAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH 

        70         80         90        100        110        120 
AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 

       130        140        150        160        170        180 
LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ 

       190        200        210        220        230        240 
PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGSD YQQLCSQQDL 

       250        260        270        280 
AMLPWVQEFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857374 mRNA. Translation: CAH89668.1.
RefSeqNP_001124754.1. NM_001131282.2.

3D structure databases

ProteinModelPortalQ5REY9.
SMRQ5REY9. Positions 28-285.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000013919; ENSPPYP00000013373; ENSPPYG00000011988.
GeneID100171604.
KEGGpon:100171604.

Organism-specific databases

CTD55586.

Phylogenomic databases

GeneTreeENSGT00390000016211.
HOVERGENHBG039556.
InParanoidQ5REY9.
KOK00469.
OMANFYREQH.
OrthoDBEOG7DZ8KD.
TreeFamTF300089.

Enzyme and pathway databases

UniPathwayUPA00111; UER00527.

Family and domain databases

InterProIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMIOX_PONAB
AccessionPrimary (citable) accession number: Q5REY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways