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Protein

Inositol oxygenase

Gene

MIOX

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: myo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Inositol oxygenase (MIOX)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29SubstrateBy similarity1
Metal bindingi98Iron 1By similarity1
Metal bindingi123Iron 1By similarity1
Metal bindingi124Iron 1By similarity1
Metal bindingi124Iron 2By similarity1
Binding sitei127SubstrateBy similarity1
Metal bindingi194Iron 2By similarity1
Metal bindingi220Iron 2By similarity1
Metal bindingi253Iron 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:MIOX
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 22

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791511 – 285Inositol oxygenaseAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013373

Structurei

3D structure databases

ProteinModelPortaliQ5REY9
SMRiQ5REY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 87Substrate bindingBy similarity3
Regioni141 – 142Substrate bindingBy similarity2
Regioni220 – 221Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1573 Eukaryota
ENOG410XQ4J LUCA
GeneTreeiENSGT00390000016211
HOVERGENiHBG039556
InParanoidiQ5REY9
KOiK00469
OMAiHEKQTVA
OrthoDBiEOG091G0FIX
TreeFamiTF300089

Family and domain databases

InterProiView protein in InterPro
IPR007828 Inositol_oxygenase
PANTHERiPTHR12588 PTHR12588, 1 hit
PfamiView protein in Pfam
PF05153 MIOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q5REY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVGPDPS LVYRPDVDPE MAKDKASFRN YTSGPLLDRV FTTYKLMHTH
60 70 80 90 100
QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF
110 120 130 140 150
QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP
160 170 180 190 200
QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ
210 220 230 240 250
VMKFNKFSLP PEAFYMIRFH SFYPWHTGSD YQQLCSQQDL AMLPWVQEFN
260 270 280
KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW
Length:285
Mass (Da):32,944
Last modified:December 21, 2004 - v1
Checksum:iD4481A96F29069D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857374 mRNA Translation: CAH89668.1
RefSeqiNP_001124754.1, NM_001131282.2

Genome annotation databases

EnsembliENSPPYT00000013919; ENSPPYP00000013373; ENSPPYG00000011988
GeneIDi100171604
KEGGipon:100171604

Similar proteinsi

Entry informationi

Entry nameiMIOX_PONAB
AccessioniPrimary (citable) accession number: Q5REY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health