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Q5REY9

- MIOX_PONAB

UniProt

Q5REY9 - MIOX_PONAB

Protein

Inositol oxygenase

Gene

MIOX

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291SubstrateBy similarity
    Metal bindingi98 – 981Iron 1By similarity
    Metal bindingi123 – 1231Iron 1By similarity
    Metal bindingi124 – 1241Iron 1By similarity
    Metal bindingi124 – 1241Iron 2By similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Metal bindingi194 – 1941Iron 2By similarity
    Metal bindingi220 – 2201Iron 2By similarity
    Metal bindingi253 – 2531Iron 1By similarity

    GO - Molecular functioni

    1. aldo-keto reductase (NADP) activity Source: Ensembl
    2. ferric iron binding Source: UniProtKB
    3. inositol oxygenase activity Source: UniProtKB
    4. oxidoreductase activity, acting on NAD(P)H Source: Ensembl

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Gene namesi
    Name:MIOX
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 22

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Inositol oxygenasePRO_0000079151Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5REY9.
    SMRiQ5REY9. Positions 28-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 873Substrate bindingBy similarity
    Regioni141 – 1422Substrate bindingBy similarity
    Regioni220 – 2212Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000016211.
    HOVERGENiHBG039556.
    InParanoidiQ5REY9.
    KOiK00469.
    OMAiNFYREQH.
    OrthoDBiEOG7DZ8KD.
    TreeFamiTF300089.

    Family and domain databases

    InterProiIPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5REY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVTVGPDPS LVYRPDVDPE MAKDKASFRN YTSGPLLDRV FTTYKLMHTH    50
    QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF 100
    QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP 150
    QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ 200
    VMKFNKFSLP PEAFYMIRFH SFYPWHTGSD YQQLCSQQDL AMLPWVQEFN 250
    KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW 285
    Length:285
    Mass (Da):32,944
    Last modified:December 21, 2004 - v1
    Checksum:iD4481A96F29069D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857374 mRNA. Translation: CAH89668.1.
    RefSeqiNP_001124754.1. NM_001131282.2.

    Genome annotation databases

    EnsembliENSPPYT00000013919; ENSPPYP00000013373; ENSPPYG00000011988.
    GeneIDi100171604.
    KEGGipon:100171604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857374 mRNA. Translation: CAH89668.1 .
    RefSeqi NP_001124754.1. NM_001131282.2.

    3D structure databases

    ProteinModelPortali Q5REY9.
    SMRi Q5REY9. Positions 28-285.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000013919 ; ENSPPYP00000013373 ; ENSPPYG00000011988 .
    GeneIDi 100171604.
    KEGGi pon:100171604.

    Organism-specific databases

    CTDi 55586.

    Phylogenomic databases

    GeneTreei ENSGT00390000016211.
    HOVERGENi HBG039556.
    InParanoidi Q5REY9.
    KOi K00469.
    OMAi NFYREQH.
    OrthoDBi EOG7DZ8KD.
    TreeFami TF300089.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .

    Family and domain databases

    InterProi IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiMIOX_PONAB
    AccessioniPrimary (citable) accession number: Q5REY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3