Reviewed, UniProtKB/Swiss-Prot Q5REY9 (MIOX_PONAB)

Names and origin

Protein names

Recommended name:
    Inositol oxygenase
    EC=1.13.99.1
Alternative name(s):
    Myo-inositol oxygenase
      Short name=MI oxygenase

Gene names

Name:

MIOX

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Myo-inositol + O(2) = D-glucuronate + H(2)O.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the myo-inositol oxygenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	inositol oxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Inositol oxygenase		PRO_0000079151
Sites
	Metal binding	98	1	Iron 1 By similarity
	Metal binding	123	1	Iron 1 By similarity
	Metal binding	124	1	Iron 1 By similarity
	Metal binding	124	1	Iron 2 By similarity
	Metal binding	194	1	Iron 2 By similarity
	Metal binding	220	1	Iron 2 By similarity
	Metal binding	253	1	Iron 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5REY9-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: D4481A96F29069D6	FASTA	285	32,944
	10 20 30 40 50 60 MKVTVGPDPS LVYRPDVDPE MAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH 70 80 90 100 110 120 AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 130 140 150 160 170 180 LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ 190 200 210 220 230 240 PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGSD YQQLCSQQDL 250 260 270 280 AMLPWVQEFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857374 mRNA. Translation: CAH89668.1.
RefSeq	NP_001124754.1.
3D structure databases
SMR	Q5REY9. Positions 28-285.
ModBase	Search...
Genome annotation databases
GeneID	100171604.
Phylogenomic databases
HOVERGEN	Q5REY9.
Family and domain databases
InterPro	IPR007828. DUF706. [Graphical view]
PANTHER	PTHR12588. DUF706. 1 hit.
Pfam	PF05153. DUF706. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MIOX_PONAB

Accession

Primary (citable) accession number: Q5REY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)