Q5REV5 (ACSM3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-coenzyme A synthetase ACSM3, mitochondrial
EC=6.2.1.2

Alternative name(s):
Acyl-CoA synthetase medium-chain family member 3
Butyrate--CoA ligase 3
Butyryl-coenzyme A synthetase 3
Middle-chain acyl-CoA synthetase 3
Protein SA homolog

Gene names

Name:	ACSM3
Synonyms:	SAH

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	586 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) By similarity.
Catalytic activity	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW butyrate-CoA ligase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 27	27	Mitochondrion Potential
	Chain	28 – 586	559	Acyl-coenzyme A synthetase ACSM3, mitochondrial		PRO_0000306099
Regions
	Nucleotide binding	235 – 243	9	ATP By similarity
	Nucleotide binding	374 – 379	6	ATP By similarity
Sites
	Binding site	461	1	ATP By similarity
	Binding site	476	1	ATP By similarity
	Binding site	572	1	ATP By similarity
Amino acid modifications
	Modified residue	43	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5REV5 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: A923438898F18582	FASTA	586	66,060
	10 20 30 40 50 60 MLACVTMKML RHAKCFQRLA IFGSVRALHK DNRTATPQNF SNYESMKQDF KLGIPEYFNF 70 80 90 100 110 120 AKDVLDQWTD KEKAGKKPSN PAFWWINRNG EEVRWSFEEL GSLSRKFANI LSEACSLQRG 130 140 150 160 170 180 DRVILILPRV PEWWLANVAC LRTGTVLIPG TTQLTQKDIL YRLQSSKANC IITNDVLAPA 190 200 210 220 230 240 VDAVAPKCEN LHSKLIVSEN SREGWGNLKE MMKHASDSHT CVKTKHNEIM AIFFTSGTSG 250 260 270 280 290 300 YPKMTAHTHS SFGLGLSVNG RFWLDLTPSD VMWNTSDTGW AKSAWSSVFS PWIQGACVFT 310 320 330 340 350 360 HHLPRFEPTS ILQTLSKYPI TVFCSAPTVY RMLVQNDMAS YKFKSLKHCV SAGEPITPDV 370 380 390 400 410 420 TEKWRNKTGL DIYEGYGQTE TVLICGNFKG MKIKPGSMGK PSPAFDVKIV DVNGNVLPPG 430 440 450 460 470 480 QEGDIGIQVL PNRPFGLFTH YVDNPSKTAS TLRGNFYITG DRGYMDEDGY FWFVARADDV 490 500 510 520 530 540 ILSSGYRIGP FEVENALNEH PSVAESAVVS SPDPIRGEVV KAFVVLNPDY KSHDQEQLIK 550 560 570 580 EIQEHVKKTT APYKYPRKVE FIQELPKTIS GKTKRNELRK KEWKTI

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857411 mRNA. Translation: CAH89702.1.
RefSeq	NP_001124772.1. NM_001131300.1.
UniGene	Pab.12217.
3D structure databases
HSSP	HSSP built from PDB template 1LCI based on UniProtKB P08659.
ProteinModelPortal	Q5REV5.
SMR	Q5REV5. Positions 53-584.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000008431; ENSPPYP00000008096; ENSPPYG00000007161.
GeneID	100171624.
KEGG	pon:100171624.
Organism-specific databases
CTD	6296.
Phylogenomic databases
HOVERGEN	HBG053031.
InParanoid	Q5REV5.
OMA	KFPITVF.
OrthoDB	EOG4ZPDTX.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01896.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSM3_PONAB

Accession

Primary (citable) accession number: Q5REV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 21, 2004
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program