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Q5RET2 (FKBP7_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7

Short name=PPIase FKBP7
EC=5.2.1.8
Alternative name(s):
FK506-binding protein 7
Short name=FKBP-7
Rotamase
Gene names
Name:FKBP7
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subcellular location

Endoplasmic reticulum lumen By similarity.

Post-translational modification

Glycosylated By similarity.

Miscellaneous

Binds calcium By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   Molecular functionIsomerase
Rotamase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

peptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 222199Peptidyl-prolyl cis-trans isomerase FKBP7
PRO_0000025515

Regions

Domain53 – 14593PPIase FKBP-type
Domain145 – 18036EF-hand 1
Domain189 – 22234EF-hand 2
Calcium binding158 – 169121 Potential
Calcium binding202 – 213122 Potential
Motif219 – 2224Prevents secretion from ER Potential

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RET2 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 505149CC0E68DE07

FASTA22225,824
        10         20         30         40         50         60 
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE RTEEVKIEVL HRPENCSKTS KKGDLLNAHY 

        70         80         90        100        110        120 
DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 

       130        140        150        160        170        180 
KEGYAEGKIP PDATLIFEIE LYAVTKGPRS TETFKQIDMD SDRQLSKAEI NLYLQREFEK 

       190        200        210        220 
DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857434 mRNA. Translation: CAH89725.1.
RefSeqNP_001124786.1. NM_001131314.1.
UniGenePab.12281.

3D structure databases

ProteinModelPortalQ5RET2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100171639.
KEGGpon:100171639.

Organism-specific databases

CTD51661.

Phylogenomic databases

HOVERGENHBG051623.
InParanoidQ5RET2.
KOK09573.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKBP7_PONAB
AccessionPrimary (citable) accession number: Q5RET2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families