Q5RET2 (FKBP7_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7
Short name=PPIase FKBP7
EC=5.2.1.8

Alternative name(s):
FK506-binding protein 7
Short name=FKBP-7
Rotamase

Gene names

Name:

FKBP7

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Endoplasmic reticulum lumen By similarity.
Post-translational modification	Glycosylated By similarity.
Miscellaneous	Binds calcium By similarity.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Ligand	Calcium Metal-binding
Molecular function	Isomerase Rotamase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 222	199	Peptidyl-prolyl cis-trans isomerase FKBP7		PRO_0000025515
Regions
	Domain	53 – 145	93	PPIase FKBP-type
	Domain	145 – 180	36	EF-hand 1
	Domain	189 – 222	34	EF-hand 2
	Calcium binding	158 – 169	12	1 Potential
	Calcium binding	202 – 213	12	2 Potential
	Motif	219 – 222	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5RET2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 505149CC0E68DE07	FASTA	222	25,824
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE RTEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYAEGKIP PDATLIFEIE LYAVTKGPRS TETFKQIDMD SDRQLSKAEI NLYLQREFEK 190 200 210 220 DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857434 mRNA. Translation: CAH89725.1.
RefSeq	NP_001124786.1. NM_001131314.1.
UniGene	Pab.12281.
3D structure databases
ProteinModelPortal	Q5RET2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100171639.
KEGG	pon:100171639.
Organism-specific databases
CTD	51661.
Phylogenomic databases
HOVERGEN	HBG051623.
InParanoid	Q5RET2.
KO	K09573.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
PANTHER	PTHR10516. PTHR10516. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKBP7_PONAB

Accession

Primary (citable) accession number: Q5RET2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program