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Protein

Maspardin

Gene

SPG21

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role as a negative regulatory factor in CD4-dependent T-cell activation.By similarity

GO - Molecular functioni

Protein family/group databases

ESTHERiponab-SPG21 Maspardin-ACP33-SPG21_like

Names & Taxonomyi

Protein namesi
Recommended name:
Maspardin
Alternative name(s):
Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
Gene namesi
Name:SPG21
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279831 – 308MaspardinAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with CD4. Interacts with ALDH16A1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000024383

Structurei

3D structure databases

ProteinModelPortaliQ5RES2
SMRiQ5RES2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 159AB hydrolase-1Sequence analysisAdd BLAST73

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IETY Eukaryota
ENOG410XPCG LUCA
HOVERGENiHBG080704
InParanoidiQ5RES2
KOiK19367

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR026151 Maspardin
PANTHERiPTHR15913 PTHR15913, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RES2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP
60 70 80 90 100
PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL
110 120 130 140 150
DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN
160 170 180 190 200
SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL
210 220 230 240 250
TLNCQNSYVE PHKIRDIPVT IMDVFGQSAL STEAKEEMYK LYPNARRAHL
260 270 280 290 300
KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS

LGISQEEQ
Length:308
Mass (Da):34,902
Last modified:December 21, 2004 - v1
Checksum:i40C4F5DB4E7F8381
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226G → D in CAH92231 (Ref. 1) Curated1
Sequence conflicti233E → G in CAH92231 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857444 mRNA Translation: CAH89735.1
CR860085 mRNA Translation: CAH92231.1
RefSeqiNP_001127527.1, NM_001134055.1
UniGeneiPab.11582

Genome annotation databases

GeneIDi100174603
KEGGipon:100174603

Similar proteinsi

Entry informationi

Entry nameiSPG21_PONAB
AccessioniPrimary (citable) accession number: Q5RES2
Secondary accession number(s): Q5R7M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 21, 2004
Last modified: February 15, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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