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Q5REQ1 (HYAL3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-3

Short name=Hyal-3
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene names
Name:HYAL3
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subcellular location

Secreted By similarity. Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Ontologies

Keywords
   Cellular componentLysosome
Secreted
   DomainEGF-like domain
Signal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

lysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 414394Hyaluronidase-3
PRO_0000248203

Regions

Domain349 – 40456EGF-like

Sites

Active site1291Proton donor By similarity

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 328 By similarity
Disulfide bond205 ↔ 220 By similarity
Disulfide bond353 ↔ 364 By similarity
Disulfide bond358 ↔ 392 By similarity
Disulfide bond394 ↔ 403 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5REQ1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: CBE2FB0A6F8633A8

FASTA41446,114
        10         20         30         40         50         60 
MTTRLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCKSRFGVHL PLNALGIIAN 

        70         80         90        100        110        120 
RGQHFHGQNM TIFYKNQLGL YPYFGPKGTA HNGGIPQALP LDRHLALAAY QIHHSLRPGF 

       130        140        150        160        170        180 
AGPAVLDWEE WCPLWAGNWG RRRAYQAASW AWAQQVFPDL DPQEQLYKAY TGFEQAARAL 

       190        200        210        220        230        240 
MEDTLRVAQA LRPHGLWGFY HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA 

       250        260        270        280        290        300 
LFPSIYLPPR LPPAHHQAFV RHRLEEAFRV ALVGHLPVLA YVRLTHRRSG RFLSQDDLVQ 

       310        320        330        340        350        360 
TIGVSAALGA AGVVLWGDLS LSSSEEECWH LHDYLVDTLG PYGINVTRAA MACSHQRCHG 

       370        380        390        400        410 
HGRCARRDPG QMEAFLHLWP DGSLGDWKSF SCHCYWGWAG PTCQEPRLGP KEAV 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857468 mRNA. Translation: CAH89756.1.
UniGenePab.19855.

3D structure databases

ProteinModelPortalQ5REQ1.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052053.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYAL3_PONAB
AccessionPrimary (citable) accession number: Q5REQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries