Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5REM7 (PPAC_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight phosphotyrosine protein phosphatase

Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48
Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2
Gene names
Name:ACP1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 158157Low molecular weight phosphotyrosine protein phosphatase
PRO_0000256845

Sites

Active site131Nucleophile By similarity
Active site191 By similarity
Active site1301Proton donor By similarity

Amino acid modifications

Modified residue21N-acetylalanine
Modified residue1321Phosphotyrosine By similarity
Modified residue1331Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5REM7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5617782F280321DC

FASTA15818,086
        10         20         30         40         50         60 
MAEQSTKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 

        70         80         90        100        110        120 
QSCMKRHGIP MSHVARQITR EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY 

       130        140        150 
DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857496 mRNA. Translation: CAH89780.1.
RefSeqNP_001124815.1. NM_001131343.1.
UniGenePab.17095.

3D structure databases

ProteinModelPortalQ5REM7.
SMRQ5REM7. Positions 2-158.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5REM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100171673.
KEGGpon:100171673.

Organism-specific databases

CTD52.

Phylogenomic databases

HOVERGENHBG007540.
InParanoidQ5REM7.
KOK14394.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPAC_PONAB
AccessionPrimary (citable) accession number: Q5REM7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families