Q5REM7 (PPAC_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight phosphotyrosine protein phosphatase
Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48

Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2

Gene names

Name:

ACP1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell internal side of plasma membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC non-membrane spanning protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 158	157	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000256845
Sites
	Active site	13	1	Nucleophile By similarity
	Active site	19	1	By similarity
	Active site	130	1	Proton donor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine
	Modified residue	132	1	Phosphotyrosine By similarity
	Modified residue	133	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5REM7 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 5617782F280321DC	FASTA	158	18,086
	10 20 30 40 50 60 MAEQSTKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 70 80 90 100 110 120 QSCMKRHGIP MSHVARQITR EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY 130 140 150 DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857496 mRNA. Translation: CAH89780.1.
RefSeq	NP_001124815.1. NM_001131343.1.
UniGene	Pab.17095.
3D structure databases
HSSP	HSSP built from PDB template 5PNT based on UniProtKB P24666.
ProteinModelPortal	Q5REM7.
SMR	Q5REM7. Positions 2-158.
ModBase	Search...
Proteomic databases
PRIDE	Q5REM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100171673.
KEGG	pon:100171673.
Organism-specific databases
CTD	52.
Phylogenomic databases
HOVERGEN	HBG007540.
InParanoid	Q5REM7.
KO	K14394.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPAC_PONAB

Accession

Primary (citable) accession number: Q5REM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 23, 2007
Last modified:	March 6, 2013
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program