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Q5REM7

- PPAC_PONAB

UniProt

Q5REM7 - PPAC_PONAB

Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131NucleophileBy similarity
    Active sitei19 – 191By similarity
    Active sitei130 – 1301Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. non-membrane spanning protein tyrosine phosphatase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
    Short name:
    LMW-PTP
    Short name:
    LMW-PTPase
    Alternative name(s):
    Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:ACP1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 158157Low molecular weight phosphotyrosine protein phosphatasePRO_0000256845Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine
    Modified residuei132 – 1321PhosphotyrosineBy similarity
    Modified residuei133 – 1331PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ5REM7.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5REM7.
    SMRiQ5REM7. Positions 2-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG007540.
    InParanoidiQ5REM7.
    KOiK14394.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5REM7-1 [UniParc]FASTAAdd to Basket

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    MAEQSTKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY    50
    EIGNPPDYRG QSCMKRHGIP MSHVARQITR EDFATFDYIL CMDESNLRDL 100
    NRKSNQVKTC KAKIELLGSY DPQKQLIIED PYYGNDSDFE TVYQQCVRCC 150
    RAFLEKAH 158
    Length:158
    Mass (Da):18,086
    Last modified:January 23, 2007 - v3
    Checksum:i5617782F280321DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857496 mRNA. Translation: CAH89780.1.
    RefSeqiNP_001124815.1. NM_001131343.1.
    UniGeneiPab.17095.

    Genome annotation databases

    GeneIDi100171673.
    KEGGipon:100171673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857496 mRNA. Translation: CAH89780.1 .
    RefSeqi NP_001124815.1. NM_001131343.1.
    UniGenei Pab.17095.

    3D structure databases

    ProteinModelPortali Q5REM7.
    SMRi Q5REM7. Positions 2-158.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5REM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100171673.
    KEGGi pon:100171673.

    Organism-specific databases

    CTDi 52.

    Phylogenomic databases

    HOVERGENi HBG007540.
    InParanoidi Q5REM7.
    KOi K14394.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiPPAC_PONAB
    AccessioniPrimary (citable) accession number: Q5REM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3