Reviewed,
UniProtKB/Swiss-Prot Q5REK3 (MPPB_PONAB)
Last modified
June 16, 2009.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mitochondrial-processing peptidase subunit beta EC=3.4.24.64 Alternative name(s): Beta-MPP | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 489 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cleaves presequences (transit peptides) from mitochondrial protein precursors By similarity. |
| Catalytic activity | Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Heterodimer of alpha and beta subunits By similarity. |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the peptidase M16 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Metalloprotease Protease |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 45 | 45 | Mitochondrion Potential | ||||||
| Chain | 46 – 489 | 444 | Mitochondrial-processing peptidase subunit beta | PRO_0000045851 | |||||
Sites | |||||||||
| Active site | 104 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 101 | 1 | Zinc By similarity | ||||||
| Metal binding | 105 | 1 | Zinc By similarity | ||||||
| Metal binding | 181 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart. |
Cross-references
Sequence databases | |
|---|---|
| CR857522 mRNA. Translation: CAH89804.1. | |
| RefSeq | NP_001127198.1. |
| UniGene | Pab.18124 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | M16.003. |
Genome annotation databases | |
| GeneID | 100174253. |
Phylogenomic databases | |
| HOVERGEN | Q5REK3. |
Enzyme and pathway databases | |
| BRENDA | 3.4.24.64. 269192. |
Family and domain databases | |
| InterPro | IPR011237. Pept_M16_core. IPR011765. Pept_M16_N. IPR001431. Pept_M16_Zn_BS. IPR007863. Peptidase_M16_C. [Graphical view] |
| Gene3D | G3DSA:3.30.830.10. Pept_M16_core. 2 hits. |
| Pfam | PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view] |
| PROSITE | PS00143. INSULINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPPB_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5REK3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


