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Q5RED7

- AGK_PONAB

UniProt

Q5RED7 - AGK_PONAB

Protein

Acylglycerol kinase, mitochondrial

Gene

AGK

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth By similarity.By similarity

    Catalytic activityi

    ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acylglycerol kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. ceramide kinase activity Source: Ensembl
    4. diacylglycerol kinase activity Source: UniProtKB-EC
    5. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. ceramide biosynthetic process Source: Ensembl
    2. glycerolipid metabolic process Source: UniProtKB-UniPathway
    3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00230.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
    Alternative name(s):
    Multiple substrate lipid kinase
    Short name:
    MuLK
    Short name:
    Multi-substrate lipid kinase
    Gene namesi
    Name:AGK
    Synonyms:MULK
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131MitochondrionSequence AnalysisAdd
    BLAST
    Chaini32 – 422391Acylglycerol kinase, mitochondrialPRO_0000252382Add
    BLAST

    Proteomic databases

    PRIDEiQ5RED7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 199142DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    GeneTreeiENSGT00690000101761.
    HOVERGENiHBG080751.
    InParanoidiQ5RED7.
    KOiK09881.
    OMAiTKAAHFF.
    OrthoDBiEOG7P2XS5.
    TreeFamiTF320485.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RED7-1 [UniParc]FASTAAdd to Basket

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    MTVFFKTLRN HWKKTTAGLC LLTWGGHWLY GKHCDNLLRR AACQEAQVFG    50
    NQLIPPNAQV KKATVFLNPA ACKGKARTLF EKNAAPILHL CGMDVTIVKT 100
    DYEGQAKKLL ELMENTDVII VAGGDGTLQE VVTGVLRRTD EATFSKIPIG 150
    FIPLGETSSL SHTLFAESGN KVQHITDATL AIVKGETVPL DVLQIKGEKE 200
    QPVFAMTGLR WGSFRDAGVK VSKYWYLGPL KIKAAHFFST LKEWPQTHQA 250
    SISYTGPTER PPSEPEETPV QRPSLYRRIL RRLASYWAQP QDALSQEVSP 300
    EVWKDVQLST IELSITTRNN QLDPTSKEDF LNICIEPDTI SKGDFITIGS 350
    RKVRNPKLHA EGTECLQASQ CTLLIPEGAG GSFSIDSEEY EAMPVEVKLL 400
    PRKLQFFCDP RKREQMLTSP AQ 422
    Length:422
    Mass (Da):47,068
    Last modified:December 21, 2004 - v1
    Checksum:iA3E092F9632A6538
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857592 mRNA. Translation: CAH89870.1.
    RefSeqiNP_001124872.1. NM_001131400.1.

    Genome annotation databases

    EnsembliENSPPYT00000021064; ENSPPYP00000020268; ENSPPYG00000018064.
    GeneIDi100171735.
    KEGGipon:100171735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857592 mRNA. Translation: CAH89870.1 .
    RefSeqi NP_001124872.1. NM_001131400.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RED7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000021064 ; ENSPPYP00000020268 ; ENSPPYG00000018064 .
    GeneIDi 100171735.
    KEGGi pon:100171735.

    Organism-specific databases

    CTDi 55750.

    Phylogenomic databases

    GeneTreei ENSGT00690000101761.
    HOVERGENi HBG080751.
    InParanoidi Q5RED7.
    KOi K09881.
    OMAi TKAAHFF.
    OrthoDBi EOG7P2XS5.
    TreeFami TF320485.

    Enzyme and pathway databases

    UniPathwayi UPA00230 .

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiAGK_PONAB
    AccessioniPrimary (citable) accession number: Q5RED7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3