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Q5RE60 (AOFA_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amine oxidase [flavin-containing] A

EC=1.4.3.4
Alternative name(s):
Monoamine oxidase type A
Short name=MAO-A
Gene names
Name:MAOA
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activity

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactor

FAD By similarity.

Subunit structure

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Amine oxidase [flavin-containing] A
PRO_0000099853

Regions

Topological domain1 – 497497Cytoplasmic By similarity
Transmembrane498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Topological domain519 – 5279Mitochondrial intermembrane By similarity
Region520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sites

Site3351Important for substrate specificity By similarity
Site3741Important for catalytic activity By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4061S-8alpha-FAD cysteine By similarity

Experimental info

Sequence conflict3821G → E in CAH89637. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5RE60 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 8CC74D22F867CE8F

FASTA52759,666
        10         20         30         40         50         60 
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG RTYTIRNEHV 

        70         80         90        100        110        120 
DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY VKGKTYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT IDNMGKEIPA DAPWEAQHAD EWDKMTMKEL IDKICWTKTA RRFAYLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL 

       250        260        270        280        290        300 
NHPVTHVDQS SNNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM 

       310        320        330        340        350        360 
GAIIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG 

       430        440        450        460        470        480 
RVIRQPVGRI FFAGTETATK WSGYMEGAVE AGERAAREVL NGLGKVTEKD IWVQEPESKD 

       490        500        510        520 
VPAVEITHTF WERNLPSVSG LLKIIGFSTS VTALGFVLYK YKLLPRS 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857341 mRNA. Translation: CAH89637.1.
CR857677 mRNA. Translation: CAH89947.1.
RefSeqNP_001124913.1. NM_001131441.1.

3D structure databases

ProteinModelPortalQ5RE60.
SMRQ5RE60. Positions 12-524.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100171783.
KEGGpon:100171783.

Organism-specific databases

CTD4128.

Phylogenomic databases

HOVERGENHBG004255.
InParanoidQ5RE60.
KOK00274.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Entry information

Entry nameAOFA_PONAB
AccessionPrimary (citable) accession number: Q5RE60
Secondary accession number(s): Q5RF20
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families