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Protein

Anaphase-promoting complex subunit 5

Gene

ANAPC5

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 5
Short name:
APC5
Alternative name(s):
Cyclosome subunit 5
Gene namesi
Name:ANAPC5
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Anaphase-promoting complex subunit 5PRO_0000307376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei195 – 1951PhosphoserineBy similarity
Modified residuei232 – 2321PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RE52.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005751.

Structurei

3D structure databases

ProteinModelPortaliQ5RE52.
SMRiQ5RE52. Positions 27-755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 24941TPR 1Add
BLAST
Repeati250 – 30051TPR 2Add
BLAST
Repeati301 – 33737TPR 3Add
BLAST
Repeati338 – 37841TPR 4Add
BLAST
Repeati379 – 41840TPR 5Add
BLAST
Repeati419 – 46648TPR 6Add
BLAST
Repeati467 – 50034TPR 7Add
BLAST
Repeati501 – 54040TPR 8Add
BLAST
Repeati541 – 58040TPR 9Add
BLAST
Repeati581 – 62040TPR 10Add
BLAST
Repeati621 – 66040TPR 11Add
BLAST
Repeati661 – 69636TPR 12Add
BLAST
Repeati697 – 73640TPR 13Add
BLAST

Sequence similaritiesi

Belongs to the APC5 family.Curated
Contains 13 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
GeneTreeiENSGT00390000018674.
HOVERGENiHBG001285.
InParanoidiQ5RE52.
KOiK03352.
OMAiLYWRSSC.
OrthoDBiEOG091G05K7.
TreeFamiTF105444.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12862. ANAPC5. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5RE52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG
60 70 80 90 100
AVSLMERRRL NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM
110 120 130 140 150
AEGELKDMEQ FFDDLSDSFS GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ
160 170 180 190 200
VFKLYTALQQ YFQNGEKKTV EDADMELTSR DEGERKMEKE ELDVSVREEE
210 220 230 240 250
VSCSGPLSQK QAEFFLSQQA SLLKNDETKA LTPASLQKEL NNLLKFNPDF
260 270 280 290 300
AEAHYLSYLN NLRVQDVFSS THSLLHYFDR LILTGAESKS NGEEGYGRSL
310 320 330 340 350
RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLYVL
360 370 380 390 400
GQKRSDSYVL LEHSVKKAVH FGLPYLASLG IQSLVQQRAF AGKTANKLMD
410 420 430 440 450
ALKDSDLLHW KHSLSELIDI SIAQKTAIWR LYGRSTMALQ QAQMLLSMNS
460 470 480 490 500
LEAVNAGVQQ NNTESFAVAL CHLAELHAEQ GCFAAASEVL KHLKERFPPN
510 520 530 540 550
SQHAQLWMLC DQKIQFDRAM NDGKYHLADS LVTGITALNS IEGVYRKAVV
560 570 580 590 600
LQAQNQMSEA HKLLQKLLVH CQKLKNTEMV ISVLLSVAEL YWRSSSPTIA
610 620 630 640 650
LPMLLQALAL SKEYRLQYLA SETVLNLAFA QLILGIPEQA LSLLHMAIEP
660 670 680 690 700
ILADGAILDK GRAMFLVAKC QVASAASYDQ PKKAEALEAA IENLNEAKNY
710 720 730 740 750
FAKVDCKERI RDVVYFQARL YHTLGKTQER NRCAMLFRQL HQELPSHGVP

LINHL
Length:755
Mass (Da):85,077
Last modified:December 21, 2004 - v1
Checksum:i174F68EAB44760EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857685 mRNA. Translation: CAH89955.1.
RefSeqiNP_001124917.1. NM_001131445.1.

Genome annotation databases

EnsembliENSPPYT00000005971; ENSPPYP00000005751; ENSPPYG00000005048.
GeneIDi100171787.
KEGGipon:100171787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857685 mRNA. Translation: CAH89955.1.
RefSeqiNP_001124917.1. NM_001131445.1.

3D structure databases

ProteinModelPortaliQ5RE52.
SMRiQ5RE52. Positions 27-755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005751.

Proteomic databases

PRIDEiQ5RE52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000005971; ENSPPYP00000005751; ENSPPYG00000005048.
GeneIDi100171787.
KEGGipon:100171787.

Organism-specific databases

CTDi51433.

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
GeneTreeiENSGT00390000018674.
HOVERGENiHBG001285.
InParanoidiQ5RE52.
KOiK03352.
OMAiLYWRSSC.
OrthoDBiEOG091G05K7.
TreeFamiTF105444.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12862. ANAPC5. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAPC5_PONAB
AccessioniPrimary (citable) accession number: Q5RE52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.