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Protein

Trichoplein keratin filament-binding protein

Gene

TCHP

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Trichoplein keratin filament-binding protein
Short name:
Protein TCHP
Alternative name(s):
Mitochondrial protein with oncostatic activity
Short name:
Mitostatin
Gene namesi
Name:TCHPBy similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926111 – 498Trichoplein keratin filament-binding proteinAdd BLAST498

Post-translational modificationi

Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ5RE49.

Interactioni

Subunit structurei

Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Interacts with KCTD17 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RE49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 498Interaction with keratin proteinsBy similarityAdd BLAST426
Regioni259 – 425Trichohyalin/plectin homology domainBy similarityAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 39Sequence analysisAdd BLAST29
Coiled coili66 – 353Sequence analysisAdd BLAST288
Coiled coili380 – 479Sequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 482Glu-richSequence analysisAdd BLAST413

Sequence similaritiesi

Belongs to the TCHP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIAX. Eukaryota.
ENOG410ZEPV. LUCA.
HOVERGENiHBG097262.
InParanoidiQ5RE49.
KOiK16811.

Family and domain databases

InterProiView protein in InterPro
IPR026773. TCHP.
PANTHERiPTHR31183:SF2. PTHR31183:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RE49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTLPFYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK
60 70 80 90 100
QAEWSSKTSY QRSMHAYQRE KMKEEKRRSL EARREKLRQL MREEQDLLAR
110 120 130 140 150
ELEELRLSMN LQERRIREQH RKLKSAREEQ RKLIAEQLLY EHWKKNNPKL
160 170 180 190 200
REMELDLHQK HVINSWETQK EEKKQQEATA EEENKRYENE YERAQREALE
210 220 230 240 250
RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE QENLLKQRWE
260 270 280 290 300
LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLNRRTQQIQ EELEADRRIL
310 320 330 340 350
QALLEKEDES QRLHLARREQ VIADAAWMKQ AIEEQLQLER AREAELQMLL
360 370 380 390 400
REEAKEMWEK REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE
410 420 430 440 450
SLKHREQLIR NLEEARESAR REKEENEELK SARKQELEAQ VAERQLQAWE
460 470 480 490
ADQQEKEEEE EARRVEQLSD ALLQQEAETM AEQGYRPKPY GHPKIAWN
Length:498
Mass (Da):61,170
Last modified:December 21, 2004 - v1
Checksum:i236B7C8520C4191A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857688 mRNA. Translation: CAH89958.1.
RefSeqiNP_001124920.1. NM_001131448.1.
UniGeneiPab.12202.

Genome annotation databases

GeneIDi100171790.
KEGGipon:100171790.

Similar proteinsi

Entry informationi

Entry nameiTCHP_PONAB
AccessioniPrimary (citable) accession number: Q5RE49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families