Reviewed, UniProtKB/Swiss-Prot Q5RDZ0 (KAD3_PONAB)

Names and origin

Protein names

Recommended name:
    GTP:AMP phosphotransferase mitochondrial
    EC=2.7.4.10
Alternative name(s):
    Adenylate kinase 3
      Short name=AK 3

Gene names

Name:

AK3

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	NTP + AMP = NDP + ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	GTP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: InterPro nucleoside triphosphate adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 227	226	GTP:AMP phosphotransferase mitochondrial		PRO_0000158924
Regions
	Nucleotide binding	14 – 22	9	GTP By similarity
	Nucleotide binding	91 – 98	8	AMP By similarity
Sites
	Binding site	38	1	AMP By similarity
Amino acid modifications
	Modified residue	34	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RDZ0-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: CED1EDF4FD9C9CF9	FASTA	227	25,496
	10 20 30 40 50 60 MGASARLLRA VIMGAPGSGK GTVSSRITTH FELKHLSSGD LLRDNMLRGT EIGVLAKAFI 70 80 90 100 110 120 DQGKLIPDDV MTRLALHELK NLTQYSWLLD GFPRTLPQAE ALDRAYQIDT VINLNVPFEV 130 140 150 160 170 180 IKQRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEDQT 190 200 210 220 KPVLEYYQKK GVLETFSGTE TNKVWPYVYA FLQTKVPQTS QKASVTP

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR857751 mRNA. Translation: CAH90017.1.
RefSeq	NP_001127224.1.
UniGene	Pab.11937
3D structure databases
SMR	Q5RDZ0. Positions 6-217, 7-218.
ModBase	Search...
Genome annotation databases
GeneID	100174279.
Organism-specific databases
CTD	100174279.
Phylogenomic databases
HOVERGEN	Q5RDZ0.
Enzyme and pathway databases
BRENDA	2.7.4.10. 269192.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD3_PONAB

Accession

Primary (citable) accession number: Q5RDZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	January 23, 2007
Last modified:	September 1, 2009
This is version 35 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)