Q5RDX4 (ATAD2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family AAA domain-containing protein 2
EC=3.6.1.3

Gene names

Name:

ATAD2

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	1091 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Interaction with ESR1 and NCOA3 is enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the AAA ATPase family. Contains 1 bromo domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Bromodomain Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1091	1091	ATPase family AAA domain-containing protein 2		PRO_0000084798
Regions
	Domain	832 – 902	71	Bromo
	Nucleotide binding	298 – 305	8	ATP Potential
	Coiled coil	801 – 825	25	Potential
	Coiled coil	917 – 943	27	Potential
	Compositional bias	80 – 120	41	Asp-rich
	Compositional bias	188 – 197	10	Poly-Ser
Amino acid modifications
	Modified residue	158	1	Phosphoserine By similarity
	Modified residue	168	1	Phosphoserine By similarity
	Modified residue	577	1	Phosphoserine By similarity
	Modified residue	582	1	Phosphoserine By similarity
	Modified residue	980	1	Phosphothreonine By similarity
	Modified residue	983	1	Phosphothreonine By similarity
	Modified residue	1003	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RDX4 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 897E5BB49007AD6F	FASTA	1,091	124,963
	10 20 30 40 50 60 MLFDKLITNT AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT RGKQKDIQRT 70 80 90 100 110 120 DEETTDNQEG SVESSEEGED QEHEDDGEDE DDEDEDDDDD DDDDDDDDED DEDEEDGEED 130 140 150 160 170 180 NQKRYYLRQR KATVYYQAPL EKPRHQRKPN IFYSGPASPA RPRYRLSSAG PRSPYCKRMN 190 200 210 220 230 240 RRRHAIHSSD STSSSSSEDE QHFERRRKRS RNRAINRYLP LNFRKDELKG IYKDRMKIGA 250 260 270 280 290 300 SLADVDPMQL DSSVRFDSVG GLSNHIAALK EMVVFPLLYP EVFEKFKIQP PRGCLFYGPP 310 320 330 340 350 360 GTGKTLVARA LANECSQGDK RVAFFMRKGA DCLSKWVGES ERQLRLLFDQ AYQMRPSIIF 370 380 390 400 410 420 FDEIDGLAPV RSSRQDQIHS SIVSTLLALM DGLDSRGEIV VIGATNRLDA IDPALRRPGR 430 440 450 460 470 480 FDREFLFSLP DKEARKEILK IHTRDWNPKP LDTFLEELAE NCVGYRGADI KSICAEAALC 490 500 510 520 530 540 ALRRRYPQIY TTSEKLQLDL SSINISAKDF EVAMQKMIPA SQRAVTSPGQ ALSTVVKPLL 550 560 570 580 590 600 QNTVDKILEA LQRVFPHAEF RTNKTLDSDI SCPLLESDLA YSDDDVPSVY ENGLSQKSSH 610 620 630 640 650 660 KAKDNFNFLH LNRNACYQPM SFRPRILIVG EPGFGQGSHL APAVIHALEK FTVYTLDIPV 670 680 690 700 710 720 LFGVSATSPE ETCAQVIREA KRTAPSIVYV PHIHVWWEIV GPTLKATFTT LLQNIPSFAP 730 740 750 760 770 780 VLLLATSDKS HSALPEEVQE LFIRDYGEIF NVQLPGKEER TKFFEDLILK QAAKPPISKK 790 800 810 820 830 840 KAVLQALEVL PVAPPPEPRS LTAEEVKRLE EQEEDTFREL RIFLRNVTHR LAIDKRFRVF 850 860 870 880 890 900 TKPVDPDEVP DYVTVIKQPM DLSSVISKID LHKYLTVKDY LRDIDLICSN ALEYNPDRDP 910 920 930 940 950 960 GDRLIRHRAC ALRDTAYAII KEELDEDFEQ LCEEIQESRK KRGCSSSKYA PSYYHVMPKQ 970 980 990 1000 1010 1020 NSTLVGDKRS DPEQNEKLKT PSTPVACSTP EMCVLRMTRA RRSQVEQQQL ISVEKALAIL 1030 1040 1050 1060 1070 1080 SQPTPSLVVD HERLKNLLKT VVKKSRNYNI FQLENLYAVI SQCIYQHRKD YDKTSLIQKM 1090 EQEVENFSCS R

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857768 mRNA. Translation: CAH90033.1.
RefSeq	NP_001127227.1. NM_001133755.1.
UniGene	Pab.14230.
3D structure databases
ProteinModelPortal	Q5RDX4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100174282.
KEGG	pon:100174282.
Organism-specific databases
CTD	29028.
Phylogenomic databases
HOVERGEN	HBG080873.
Family and domain databases
Gene3D	1.20.920.10. 1 hit. 1.25.10.10. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR011989. ARM-like. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR001487. Bromodomain. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00382. AAA. 1 hit. SM00297. BROMO. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit.
PROSITE	PS00674. AAA. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATAD2_PONAB

Accession

Primary (citable) accession number: Q5RDX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program