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Q5RDX4

- ATAD2_PONAB

UniProt

Q5RDX4 - ATAD2_PONAB

Protein

ATPase family AAA domain-containing protein 2

Gene

ATAD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi298 – 3058ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
    Gene namesi
    Name:ATAD2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10911091ATPase family AAA domain-containing protein 2PRO_0000084798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei158 – 1581PhosphoserineBy similarity
    Modified residuei168 – 1681PhosphoserineBy similarity
    Modified residuei577 – 5771PhosphoserineBy similarity
    Modified residuei582 – 5821PhosphoserineBy similarity
    Modified residuei980 – 9801PhosphothreonineBy similarity
    Modified residuei983 – 9831PhosphothreonineBy similarity
    Modified residuei1003 – 10031PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interaction with ESR1 and NCOA3 is enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RDX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini832 – 90271BromoPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili801 – 82525Sequence AnalysisAdd
    BLAST
    Coiled coili917 – 94327Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi80 – 12041Asp-richAdd
    BLAST
    Compositional biasi188 – 19710Poly-Ser

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated
    Contains 1 bromo domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Coiled coil

    Phylogenomic databases

    HOVERGENiHBG080873.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    1.25.10.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011989. ARM-like.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR001487. Bromodomain.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00382. AAA. 1 hit.
    SM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEiPS00674. AAA. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RDX4-1 [UniParc]FASTAAdd to Basket

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    MLFDKLITNT AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT     50
    RGKQKDIQRT DEETTDNQEG SVESSEEGED QEHEDDGEDE DDEDEDDDDD 100
    DDDDDDDDED DEDEEDGEED NQKRYYLRQR KATVYYQAPL EKPRHQRKPN 150
    IFYSGPASPA RPRYRLSSAG PRSPYCKRMN RRRHAIHSSD STSSSSSEDE 200
    QHFERRRKRS RNRAINRYLP LNFRKDELKG IYKDRMKIGA SLADVDPMQL 250
    DSSVRFDSVG GLSNHIAALK EMVVFPLLYP EVFEKFKIQP PRGCLFYGPP 300
    GTGKTLVARA LANECSQGDK RVAFFMRKGA DCLSKWVGES ERQLRLLFDQ 350
    AYQMRPSIIF FDEIDGLAPV RSSRQDQIHS SIVSTLLALM DGLDSRGEIV 400
    VIGATNRLDA IDPALRRPGR FDREFLFSLP DKEARKEILK IHTRDWNPKP 450
    LDTFLEELAE NCVGYRGADI KSICAEAALC ALRRRYPQIY TTSEKLQLDL 500
    SSINISAKDF EVAMQKMIPA SQRAVTSPGQ ALSTVVKPLL QNTVDKILEA 550
    LQRVFPHAEF RTNKTLDSDI SCPLLESDLA YSDDDVPSVY ENGLSQKSSH 600
    KAKDNFNFLH LNRNACYQPM SFRPRILIVG EPGFGQGSHL APAVIHALEK 650
    FTVYTLDIPV LFGVSATSPE ETCAQVIREA KRTAPSIVYV PHIHVWWEIV 700
    GPTLKATFTT LLQNIPSFAP VLLLATSDKS HSALPEEVQE LFIRDYGEIF 750
    NVQLPGKEER TKFFEDLILK QAAKPPISKK KAVLQALEVL PVAPPPEPRS 800
    LTAEEVKRLE EQEEDTFREL RIFLRNVTHR LAIDKRFRVF TKPVDPDEVP 850
    DYVTVIKQPM DLSSVISKID LHKYLTVKDY LRDIDLICSN ALEYNPDRDP 900
    GDRLIRHRAC ALRDTAYAII KEELDEDFEQ LCEEIQESRK KRGCSSSKYA 950
    PSYYHVMPKQ NSTLVGDKRS DPEQNEKLKT PSTPVACSTP EMCVLRMTRA 1000
    RRSQVEQQQL ISVEKALAIL SQPTPSLVVD HERLKNLLKT VVKKSRNYNI 1050
    FQLENLYAVI SQCIYQHRKD YDKTSLIQKM EQEVENFSCS R 1091
    Length:1,091
    Mass (Da):124,963
    Last modified:December 21, 2004 - v1
    Checksum:i897E5BB49007AD6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857768 mRNA. Translation: CAH90033.1.
    RefSeqiNP_001127227.1. NM_001133755.1.
    UniGeneiPab.14230.

    Genome annotation databases

    GeneIDi100174282.
    KEGGipon:100174282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857768 mRNA. Translation: CAH90033.1 .
    RefSeqi NP_001127227.1. NM_001133755.1.
    UniGenei Pab.14230.

    3D structure databases

    ProteinModelPortali Q5RDX4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174282.
    KEGGi pon:100174282.

    Organism-specific databases

    CTDi 29028.

    Phylogenomic databases

    HOVERGENi HBG080873.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    1.25.10.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011989. ARM-like.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR001487. Bromodomain.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00382. AAA. 1 hit.
    SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEi PS00674. AAA. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiATAD2_PONAB
    AccessioniPrimary (citable) accession number: Q5RDX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3