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Q5RDX4

- ATAD2_PONAB

UniProt

Q5RDX4 - ATAD2_PONAB

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Protein

ATPase family AAA domain-containing protein 2

Gene

ATAD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi298 – 3058ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Gene namesi
Name:ATAD2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091ATPase family AAA domain-containing protein 2PRO_0000084798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei158 – 1581PhosphoserineBy similarity
Modified residuei168 – 1681PhosphoserineBy similarity
Modified residuei577 – 5771PhosphoserineBy similarity
Modified residuei582 – 5821PhosphoserineBy similarity
Modified residuei980 – 9801PhosphothreonineBy similarity
Modified residuei983 – 9831PhosphothreonineBy similarity
Modified residuei1003 – 10031PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interaction with ESR1 and NCOA3 is enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RDX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini832 – 90271BromoPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili801 – 82525Sequence AnalysisAdd
BLAST
Coiled coili917 – 94327Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 12041Asp-richAdd
BLAST
Compositional biasi188 – 19710Poly-Ser

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

HOVERGENiHBG080873.
InParanoidiQ5RDX4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RDX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFDKLITNT AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT
60 70 80 90 100
RGKQKDIQRT DEETTDNQEG SVESSEEGED QEHEDDGEDE DDEDEDDDDD
110 120 130 140 150
DDDDDDDDED DEDEEDGEED NQKRYYLRQR KATVYYQAPL EKPRHQRKPN
160 170 180 190 200
IFYSGPASPA RPRYRLSSAG PRSPYCKRMN RRRHAIHSSD STSSSSSEDE
210 220 230 240 250
QHFERRRKRS RNRAINRYLP LNFRKDELKG IYKDRMKIGA SLADVDPMQL
260 270 280 290 300
DSSVRFDSVG GLSNHIAALK EMVVFPLLYP EVFEKFKIQP PRGCLFYGPP
310 320 330 340 350
GTGKTLVARA LANECSQGDK RVAFFMRKGA DCLSKWVGES ERQLRLLFDQ
360 370 380 390 400
AYQMRPSIIF FDEIDGLAPV RSSRQDQIHS SIVSTLLALM DGLDSRGEIV
410 420 430 440 450
VIGATNRLDA IDPALRRPGR FDREFLFSLP DKEARKEILK IHTRDWNPKP
460 470 480 490 500
LDTFLEELAE NCVGYRGADI KSICAEAALC ALRRRYPQIY TTSEKLQLDL
510 520 530 540 550
SSINISAKDF EVAMQKMIPA SQRAVTSPGQ ALSTVVKPLL QNTVDKILEA
560 570 580 590 600
LQRVFPHAEF RTNKTLDSDI SCPLLESDLA YSDDDVPSVY ENGLSQKSSH
610 620 630 640 650
KAKDNFNFLH LNRNACYQPM SFRPRILIVG EPGFGQGSHL APAVIHALEK
660 670 680 690 700
FTVYTLDIPV LFGVSATSPE ETCAQVIREA KRTAPSIVYV PHIHVWWEIV
710 720 730 740 750
GPTLKATFTT LLQNIPSFAP VLLLATSDKS HSALPEEVQE LFIRDYGEIF
760 770 780 790 800
NVQLPGKEER TKFFEDLILK QAAKPPISKK KAVLQALEVL PVAPPPEPRS
810 820 830 840 850
LTAEEVKRLE EQEEDTFREL RIFLRNVTHR LAIDKRFRVF TKPVDPDEVP
860 870 880 890 900
DYVTVIKQPM DLSSVISKID LHKYLTVKDY LRDIDLICSN ALEYNPDRDP
910 920 930 940 950
GDRLIRHRAC ALRDTAYAII KEELDEDFEQ LCEEIQESRK KRGCSSSKYA
960 970 980 990 1000
PSYYHVMPKQ NSTLVGDKRS DPEQNEKLKT PSTPVACSTP EMCVLRMTRA
1010 1020 1030 1040 1050
RRSQVEQQQL ISVEKALAIL SQPTPSLVVD HERLKNLLKT VVKKSRNYNI
1060 1070 1080 1090
FQLENLYAVI SQCIYQHRKD YDKTSLIQKM EQEVENFSCS R
Length:1,091
Mass (Da):124,963
Last modified:December 21, 2004 - v1
Checksum:i897E5BB49007AD6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857768 mRNA. Translation: CAH90033.1.
RefSeqiNP_001127227.1. NM_001133755.1.
UniGeneiPab.14230.

Genome annotation databases

GeneIDi100174282.
KEGGipon:100174282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857768 mRNA. Translation: CAH90033.1 .
RefSeqi NP_001127227.1. NM_001133755.1.
UniGenei Pab.14230.

3D structure databases

ProteinModelPortali Q5RDX4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174282.
KEGGi pon:100174282.

Organism-specific databases

CTDi 29028.

Phylogenomic databases

HOVERGENi HBG080873.
InParanoidi Q5RDX4.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiATAD2_PONAB
AccessioniPrimary (citable) accession number: Q5RDX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3