Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATPase family AAA domain-containing protein 2

Gene

ATAD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi298 – 305ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Gene namesi
Name:ATAD2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847981 – 1091ATPase family AAA domain-containing protein 2Add BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphoserineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Modified residuei577PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei970PhosphoserineBy similarity1
Modified residuei980PhosphothreonineBy similarity1
Modified residuei983PhosphothreonineBy similarity1
Modified residuei1003PhosphoserineBy similarity1
Modified residuei1024PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interaction with ESR1 and NCOA3 is enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021158.

Structurei

3D structure databases

ProteinModelPortaliQ5RDX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini832 – 902BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili801 – 825Sequence analysisAdd BLAST25
Coiled coili917 – 943Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 120Asp-richAdd BLAST41
Compositional biasi188 – 197Poly-Ser10

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG0732. Eukaryota.
COG0464. LUCA.
HOVERGENiHBG080873.
InParanoidiQ5RDX4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR031252. ANCCA.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23069:SF4. PTHR23069:SF4. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RDX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFDKLITNT AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT
60 70 80 90 100
RGKQKDIQRT DEETTDNQEG SVESSEEGED QEHEDDGEDE DDEDEDDDDD
110 120 130 140 150
DDDDDDDDED DEDEEDGEED NQKRYYLRQR KATVYYQAPL EKPRHQRKPN
160 170 180 190 200
IFYSGPASPA RPRYRLSSAG PRSPYCKRMN RRRHAIHSSD STSSSSSEDE
210 220 230 240 250
QHFERRRKRS RNRAINRYLP LNFRKDELKG IYKDRMKIGA SLADVDPMQL
260 270 280 290 300
DSSVRFDSVG GLSNHIAALK EMVVFPLLYP EVFEKFKIQP PRGCLFYGPP
310 320 330 340 350
GTGKTLVARA LANECSQGDK RVAFFMRKGA DCLSKWVGES ERQLRLLFDQ
360 370 380 390 400
AYQMRPSIIF FDEIDGLAPV RSSRQDQIHS SIVSTLLALM DGLDSRGEIV
410 420 430 440 450
VIGATNRLDA IDPALRRPGR FDREFLFSLP DKEARKEILK IHTRDWNPKP
460 470 480 490 500
LDTFLEELAE NCVGYRGADI KSICAEAALC ALRRRYPQIY TTSEKLQLDL
510 520 530 540 550
SSINISAKDF EVAMQKMIPA SQRAVTSPGQ ALSTVVKPLL QNTVDKILEA
560 570 580 590 600
LQRVFPHAEF RTNKTLDSDI SCPLLESDLA YSDDDVPSVY ENGLSQKSSH
610 620 630 640 650
KAKDNFNFLH LNRNACYQPM SFRPRILIVG EPGFGQGSHL APAVIHALEK
660 670 680 690 700
FTVYTLDIPV LFGVSATSPE ETCAQVIREA KRTAPSIVYV PHIHVWWEIV
710 720 730 740 750
GPTLKATFTT LLQNIPSFAP VLLLATSDKS HSALPEEVQE LFIRDYGEIF
760 770 780 790 800
NVQLPGKEER TKFFEDLILK QAAKPPISKK KAVLQALEVL PVAPPPEPRS
810 820 830 840 850
LTAEEVKRLE EQEEDTFREL RIFLRNVTHR LAIDKRFRVF TKPVDPDEVP
860 870 880 890 900
DYVTVIKQPM DLSSVISKID LHKYLTVKDY LRDIDLICSN ALEYNPDRDP
910 920 930 940 950
GDRLIRHRAC ALRDTAYAII KEELDEDFEQ LCEEIQESRK KRGCSSSKYA
960 970 980 990 1000
PSYYHVMPKQ NSTLVGDKRS DPEQNEKLKT PSTPVACSTP EMCVLRMTRA
1010 1020 1030 1040 1050
RRSQVEQQQL ISVEKALAIL SQPTPSLVVD HERLKNLLKT VVKKSRNYNI
1060 1070 1080 1090
FQLENLYAVI SQCIYQHRKD YDKTSLIQKM EQEVENFSCS R
Length:1,091
Mass (Da):124,963
Last modified:December 21, 2004 - v1
Checksum:i897E5BB49007AD6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857768 mRNA. Translation: CAH90033.1.
RefSeqiNP_001127227.1. NM_001133755.1.
UniGeneiPab.14230.

Genome annotation databases

GeneIDi100174282.
KEGGipon:100174282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857768 mRNA. Translation: CAH90033.1.
RefSeqiNP_001127227.1. NM_001133755.1.
UniGeneiPab.14230.

3D structure databases

ProteinModelPortaliQ5RDX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174282.
KEGGipon:100174282.

Organism-specific databases

CTDi29028.

Phylogenomic databases

eggNOGiKOG0732. Eukaryota.
COG0464. LUCA.
HOVERGENiHBG080873.
InParanoidiQ5RDX4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR031252. ANCCA.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23069:SF4. PTHR23069:SF4. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATAD2_PONAB
AccessioniPrimary (citable) accession number: Q5RDX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.