Reviewed, UniProtKB/Swiss-Prot Q5RDU4 (PARP6_PONAB)

Names and origin

Protein names

Recommended name:
    Poly [ADP-ribose] polymerase 6
      Short name=PARP-6
    EC=2.4.2.30

Gene names

Name:

PARP6

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 PARP catalytic domain.

Ontologies

Keywords
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	Poly [ADP-ribose] polymerase 6		PRO_0000252432
Regions
	Domain	374 – 600	227	PARP catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q5RDU4-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 1979ECB34E1E3A08	FASTA	610	69,060
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW LKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSVSCTMKNP KVEVFGYPPS PQVSGHCKNI 250 260 270 280 290 300 PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM LKPAVCTREL CVFSFYTLGV 310 320 330 340 350 360 MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE 370 380 390 400 410 420 RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM 430 440 450 460 470 480 HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG 490 500 510 520 530 540 AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS IQSRFLQSRN 550 560 570 580 590 600 LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED GQVGDANINT QDPKIQKEIM 610 RVIGTQVYTN

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857803 mRNA. Translation: CAH90063.1.
RefSeq	NP_001124986.1.
UniGene	Pab.3341
3D structure databases
SMR	Q5RDU4. Positions 431-501.
ModBase	Search...
Genome annotation databases
GeneID	100171860.
Organism-specific databases
CTD	100171860.
Phylogenomic databases
HOVERGEN	Q5RDU4.
Enzyme and pathway databases
BRENDA	2.4.2.30. 269192.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PARP6_PONAB

Accession

Primary (citable) accession number: Q5RDU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)