Q5RDT5 (SAP18_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase complex subunit SAP18

Alternative name(s):
18 kDa Sin3-associated polypeptide
Sin3-associated polypeptide p18

Gene names

Name:

SAP18

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism By similarity.
Subunit structure	Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Forms a complex with SIN3A and HDAC1 By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Shuttles between the nucleus and the cytoplasm By similarity.
Sequence similarities	Belongs to the SAP18 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Repressor
PTM	Acetylation
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 153	152	Histone deacetylase complex subunit SAP18		PRO_0000290197
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RDT5 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: C7E479FFE9CA5774	FASTA	153	17,561
	10 20 30 40 50 60 MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT 70 80 90 100 110 120 WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM 130 140 150 TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857814 mRNA. Translation: CAH90072.1.
RefSeq	NP_001129009.1. NM_001135537.1.
UniGene	Pab.19837.
3D structure databases
ProteinModelPortal	Q5RDT5.
SMR	Q5RDT5. Positions 6-149.
ModBase	Search...
Proteomic databases
PRIDE	Q5RDT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000006154; ENSPPYP00000005921; ENSPPYG00000005198.
GeneID	100190849.
KEGG	pon:100190849.
Organism-specific databases
CTD	10284.
Phylogenomic databases
HOVERGEN	HBG003465.
InParanoid	Q5RDT5.
OMA	DISITPP.
Family and domain databases
InterPro	IPR017250. Hist_deAcase_cplx_SAP18. IPR010516. SAP18. [Graphical view]
KO	K14324.
PANTHER	PTHR13082. SAP18. 1 hit.
Pfam	PF06487. SAP18. 1 hit. [Graphical view]
PIRSF	PIRSF037637. HDAC_SAP18. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SAP18_PONAB

Accession

Primary (citable) accession number: Q5RDT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 21, 2004
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program