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Q5RDS0

- PLPL6_PONAB

UniProt

Q5RDS0 - PLPL6_PONAB

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Protein

Neuropathy target esterase

Gene

PNPLA6

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1004 – 10041By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 313128cNMP 1Add
BLAST
Nucleotide bindingi502 – 624123cNMP 2Add
BLAST
Nucleotide bindingi620 – 740121cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase (EC:3.1.1.5)
Alternative name(s):
Patatin-like phospholipase domain-containing protein 6
Gene namesi
Name:PNPLA6
Synonyms:NTE
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity; Cytoplasmic side By similarity
Note: Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13651365Neuropathy target esterasePRO_0000292201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei352 – 3521PhosphothreonineBy similarity
Modified residuei353 – 3531PhosphoserineBy similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5RDS0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050LumenalSequence AnalysisAdd
BLAST
Topological domaini72 – 13651294CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini971 – 1137167PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1002 – 10065GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053067.
InParanoidiQ5RDS0.
KOiK14676.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RDS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTSSHGLAT NSSGAKVAER DGFQDVPAPG EGAAGRICGA QPVPFVPQVL
60 70 80 90 100
GVMIGAGVAV VVTAVLILLV VRRLRVPKTP APDGPRYRFR KRDKVLFYGR
110 120 130 140 150
KIMRKVSQST SSLVDTSVSA TSRPRMKKKL KMLNIAKKIL RIQKETPTLQ
160 170 180 190 200
RKEPPPAVLE ADLTEGDLAN SHLPSEVLYM FKNVRVLGHF EKPLFLELCR
210 220 230 240 250
HMVFQRLGQG DYVFRPGQPD ASIYVVQDGL LELCLPGPDG KECVVKEVVP
260 270 280 290 300
GDSVNSLLSI LDVITGHQHP QRTVSARAAR DSTVLRLPVE AFSAVFAKYP
310 320 330 340 350
ESLVRVVQII MVRLQRVTFL ALHNYLGLTN ELFSHEIQPL RLFPSPGLPT
360 370 380 390 400
RTSPVRGSKR MVSTSATDEP RETPGRPPDP TGAPLPGPTG DPVKPTSLET
410 420 430 440 450
PSAPLLSRCV SMPGDISGLQ GGPRSDFDMA YERGRISVSL QEGASGGSLA
460 470 480 490 500
APARTPTQEP REQPAGACEY SYCEDESATG GCPFGPYQGR QTSSIFEAAK
510 520 530 540 550
RELAKLMRIE DPSLLNSRVL LHHAKAGTII ARQGDQDVSL HFVLWGCLHV
560 570 580 590 600
YQHMIDKAED VCLFVAQPGE LVGQLAVLTG EPLIFTLRAQ RDCTFLRISK
610 620 630 640 650
SDFYEIMRAQ PSVVLSAAHT VAARMSPFVR QMDFAIDWTA VEAGRALYRQ
660 670 680 690 700
GDRSDCTYIV LNGRLRSVIQ RGSGKKELVG EYGRGDLIGV VEALTRQPRA
710 720 730 740 750
TTVHAVRDTE LAKLPEGTLG HIKRRHPQVV TRLIHLLSQK ILGNLQQLQG
760 770 780 790 800
PFPGSGLGVP PHSELTNPAS NLATVAVLPV CAEVPMVAFT LELQHALQAI
810 820 830 840 850
GPTLLLNSDI IRARLGASAL DSIQEFRLSG WLAQQEDAHR IVLYQTDASL
860 870 880 890 900
TPWTVRCLRQ ADCILIVGLG DQEPTLGQLE QMLENTAVRA LKQLVLLHRE
910 920 930 940 950
EGAGPTRTVE WLNMRSWCSG HPHLRCPRRL FSRRSPAKLH ELYEKVFSRR
960 970 980 990 1000
ADRHSDFSRL ARVLTGNTIA LVLGGGGARG CSHIGVLKAL EEAGVPVDLV
1010 1020 1030 1040 1050
GGTSIGSFIG ALYAEERSAS RTKQRAREWA KSMTSVLEPV LDLTYPVTSM
1060 1070 1080 1090 1100
FTGSAFNRSI HRVFQDKQIE DLWLPYFNVT TDITASAMRV HKDGSLWRYV
1110 1120 1130 1140 1150
RASMTLSGYL PPLCDPKDGH LLMDGGYINN LPADIARSMG AKTVIAIDVG
1160 1170 1180 1190 1200
SQDETDLSTY GDSLSGWWLL WKRLNPWADK VKVPDMAEIQ SRLAYVSCVR
1210 1220 1230 1240 1250
QLEVVKSSSY CEYLRPPIDC FKTMDFGKFD QVYDVGYQYG KAVFGGWSRG
1260 1270 1280 1290 1300
NVIEKMLTDR RSTDLNESRR ADVLAYPSSG FTDLAEIVSR IEPPTSYVSD
1310 1320 1330 1340 1350
GCADGEESDC LTEYEEDAGP DCSRDEGGSP EGASPSTASE MEEEKSILRQ
1360
RRCLPQEPPG SATDA
Length:1,365
Mass (Da):149,750
Last modified:December 21, 2004 - v1
Checksum:iA700733C7A74EB39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857832 mRNA. Translation: CAH90087.1.
RefSeqiNP_001124999.1. NM_001131527.1.
UniGeneiPab.7195.

Genome annotation databases

GeneIDi100453292.
KEGGipon:100453292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857832 mRNA. Translation: CAH90087.1 .
RefSeqi NP_001124999.1. NM_001131527.1.
UniGenei Pab.7195.

3D structure databases

ProteinModelPortali Q5RDS0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100453292.
KEGGi pon:100453292.

Organism-specific databases

CTDi 10908.

Phylogenomic databases

HOVERGENi HBG053067.
InParanoidi Q5RDS0.
KOi K14676.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPLPL6_PONAB
AccessioniPrimary (citable) accession number: Q5RDS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3