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Q5RDS0 (PLPL6_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase

EC=3.1.1.5
Alternative name(s):
Patatin-like phospholipase domain-containing protein 6
Gene names
Name:PNPLA6
Synonyms:NTE
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length1365 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side By similarity. Note: Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment By similarity.

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13651365Neuropathy target esterase
PRO_0000292201

Regions

Topological domain1 – 5050Lumenal Potential
Transmembrane51 – 7121Helical; Potential
Topological domain72 – 13651294Cytoplasmic Potential
Domain971 – 1137167Patatin
Nucleotide binding186 – 313128cNMP 1
Nucleotide binding502 – 624123cNMP 2
Nucleotide binding620 – 740121cNMP 3
Motif1002 – 10065GXSXG

Sites

Active site10041 By similarity

Amino acid modifications

Modified residue3451Phosphoserine By similarity
Modified residue3521Phosphothreonine By similarity
Modified residue3531Phosphoserine By similarity
Glycosylation111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RDS0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: A700733C7A74EB39

FASTA1,365149,750
        10         20         30         40         50         60 
MGTSSHGLAT NSSGAKVAER DGFQDVPAPG EGAAGRICGA QPVPFVPQVL GVMIGAGVAV 

        70         80         90        100        110        120 
VVTAVLILLV VRRLRVPKTP APDGPRYRFR KRDKVLFYGR KIMRKVSQST SSLVDTSVSA 

       130        140        150        160        170        180 
TSRPRMKKKL KMLNIAKKIL RIQKETPTLQ RKEPPPAVLE ADLTEGDLAN SHLPSEVLYM 

       190        200        210        220        230        240 
FKNVRVLGHF EKPLFLELCR HMVFQRLGQG DYVFRPGQPD ASIYVVQDGL LELCLPGPDG 

       250        260        270        280        290        300 
KECVVKEVVP GDSVNSLLSI LDVITGHQHP QRTVSARAAR DSTVLRLPVE AFSAVFAKYP 

       310        320        330        340        350        360 
ESLVRVVQII MVRLQRVTFL ALHNYLGLTN ELFSHEIQPL RLFPSPGLPT RTSPVRGSKR 

       370        380        390        400        410        420 
MVSTSATDEP RETPGRPPDP TGAPLPGPTG DPVKPTSLET PSAPLLSRCV SMPGDISGLQ 

       430        440        450        460        470        480 
GGPRSDFDMA YERGRISVSL QEGASGGSLA APARTPTQEP REQPAGACEY SYCEDESATG 

       490        500        510        520        530        540 
GCPFGPYQGR QTSSIFEAAK RELAKLMRIE DPSLLNSRVL LHHAKAGTII ARQGDQDVSL 

       550        560        570        580        590        600 
HFVLWGCLHV YQHMIDKAED VCLFVAQPGE LVGQLAVLTG EPLIFTLRAQ RDCTFLRISK 

       610        620        630        640        650        660 
SDFYEIMRAQ PSVVLSAAHT VAARMSPFVR QMDFAIDWTA VEAGRALYRQ GDRSDCTYIV 

       670        680        690        700        710        720 
LNGRLRSVIQ RGSGKKELVG EYGRGDLIGV VEALTRQPRA TTVHAVRDTE LAKLPEGTLG 

       730        740        750        760        770        780 
HIKRRHPQVV TRLIHLLSQK ILGNLQQLQG PFPGSGLGVP PHSELTNPAS NLATVAVLPV 

       790        800        810        820        830        840 
CAEVPMVAFT LELQHALQAI GPTLLLNSDI IRARLGASAL DSIQEFRLSG WLAQQEDAHR 

       850        860        870        880        890        900 
IVLYQTDASL TPWTVRCLRQ ADCILIVGLG DQEPTLGQLE QMLENTAVRA LKQLVLLHRE 

       910        920        930        940        950        960 
EGAGPTRTVE WLNMRSWCSG HPHLRCPRRL FSRRSPAKLH ELYEKVFSRR ADRHSDFSRL 

       970        980        990       1000       1010       1020 
ARVLTGNTIA LVLGGGGARG CSHIGVLKAL EEAGVPVDLV GGTSIGSFIG ALYAEERSAS 

      1030       1040       1050       1060       1070       1080 
RTKQRAREWA KSMTSVLEPV LDLTYPVTSM FTGSAFNRSI HRVFQDKQIE DLWLPYFNVT 

      1090       1100       1110       1120       1130       1140 
TDITASAMRV HKDGSLWRYV RASMTLSGYL PPLCDPKDGH LLMDGGYINN LPADIARSMG 

      1150       1160       1170       1180       1190       1200 
AKTVIAIDVG SQDETDLSTY GDSLSGWWLL WKRLNPWADK VKVPDMAEIQ SRLAYVSCVR 

      1210       1220       1230       1240       1250       1260 
QLEVVKSSSY CEYLRPPIDC FKTMDFGKFD QVYDVGYQYG KAVFGGWSRG NVIEKMLTDR 

      1270       1280       1290       1300       1310       1320 
RSTDLNESRR ADVLAYPSSG FTDLAEIVSR IEPPTSYVSD GCADGEESDC LTEYEEDAGP 

      1330       1340       1350       1360 
DCSRDEGGSP EGASPSTASE MEEEKSILRQ RRCLPQEPPG SATDA 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857832 mRNA. Translation: CAH90087.1.
RefSeqNP_001124999.1. NM_001131527.1.
UniGenePab.7195.

3D structure databases

ProteinModelPortalQ5RDS0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100453292.
KEGGpon:100453292.

Organism-specific databases

CTD10908.

Phylogenomic databases

HOVERGENHBG053067.
InParanoidQ5RDS0.
KOK14676.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLPL6_PONAB
AccessionPrimary (citable) accession number: Q5RDS0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families