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Q5RDS0

- PLPL6_PONAB

UniProt

Q5RDS0 - PLPL6_PONAB

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Protein
Neuropathy target esterase
Gene
PNPLA6, NTE
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1004 – 10041 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 313128cNMP 1
Add
BLAST
Nucleotide bindingi502 – 624123cNMP 2
Add
BLAST
Nucleotide bindingi620 – 740121cNMP 3
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase (EC:3.1.1.5)
Alternative name(s):
Patatin-like phospholipase domain-containing protein 6
Gene namesi
Name:PNPLA6
Synonyms:NTE
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side By similarity
Note: Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Lumenal Reviewed prediction
Add
BLAST
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 13651294Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13651365Neuropathy target esterase
PRO_0000292201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Modified residuei345 – 3451Phosphoserine By similarity
Modified residuei352 – 3521Phosphothreonine By similarity
Modified residuei353 – 3531Phosphoserine By similarity

Post-translational modificationi

Glycosylated By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5RDS0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini971 – 1137167Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1002 – 10065GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053067.
InParanoidiQ5RDS0.
KOiK14676.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RDS0-1 [UniParc]FASTAAdd to Basket

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MGTSSHGLAT NSSGAKVAER DGFQDVPAPG EGAAGRICGA QPVPFVPQVL     50
GVMIGAGVAV VVTAVLILLV VRRLRVPKTP APDGPRYRFR KRDKVLFYGR 100
KIMRKVSQST SSLVDTSVSA TSRPRMKKKL KMLNIAKKIL RIQKETPTLQ 150
RKEPPPAVLE ADLTEGDLAN SHLPSEVLYM FKNVRVLGHF EKPLFLELCR 200
HMVFQRLGQG DYVFRPGQPD ASIYVVQDGL LELCLPGPDG KECVVKEVVP 250
GDSVNSLLSI LDVITGHQHP QRTVSARAAR DSTVLRLPVE AFSAVFAKYP 300
ESLVRVVQII MVRLQRVTFL ALHNYLGLTN ELFSHEIQPL RLFPSPGLPT 350
RTSPVRGSKR MVSTSATDEP RETPGRPPDP TGAPLPGPTG DPVKPTSLET 400
PSAPLLSRCV SMPGDISGLQ GGPRSDFDMA YERGRISVSL QEGASGGSLA 450
APARTPTQEP REQPAGACEY SYCEDESATG GCPFGPYQGR QTSSIFEAAK 500
RELAKLMRIE DPSLLNSRVL LHHAKAGTII ARQGDQDVSL HFVLWGCLHV 550
YQHMIDKAED VCLFVAQPGE LVGQLAVLTG EPLIFTLRAQ RDCTFLRISK 600
SDFYEIMRAQ PSVVLSAAHT VAARMSPFVR QMDFAIDWTA VEAGRALYRQ 650
GDRSDCTYIV LNGRLRSVIQ RGSGKKELVG EYGRGDLIGV VEALTRQPRA 700
TTVHAVRDTE LAKLPEGTLG HIKRRHPQVV TRLIHLLSQK ILGNLQQLQG 750
PFPGSGLGVP PHSELTNPAS NLATVAVLPV CAEVPMVAFT LELQHALQAI 800
GPTLLLNSDI IRARLGASAL DSIQEFRLSG WLAQQEDAHR IVLYQTDASL 850
TPWTVRCLRQ ADCILIVGLG DQEPTLGQLE QMLENTAVRA LKQLVLLHRE 900
EGAGPTRTVE WLNMRSWCSG HPHLRCPRRL FSRRSPAKLH ELYEKVFSRR 950
ADRHSDFSRL ARVLTGNTIA LVLGGGGARG CSHIGVLKAL EEAGVPVDLV 1000
GGTSIGSFIG ALYAEERSAS RTKQRAREWA KSMTSVLEPV LDLTYPVTSM 1050
FTGSAFNRSI HRVFQDKQIE DLWLPYFNVT TDITASAMRV HKDGSLWRYV 1100
RASMTLSGYL PPLCDPKDGH LLMDGGYINN LPADIARSMG AKTVIAIDVG 1150
SQDETDLSTY GDSLSGWWLL WKRLNPWADK VKVPDMAEIQ SRLAYVSCVR 1200
QLEVVKSSSY CEYLRPPIDC FKTMDFGKFD QVYDVGYQYG KAVFGGWSRG 1250
NVIEKMLTDR RSTDLNESRR ADVLAYPSSG FTDLAEIVSR IEPPTSYVSD 1300
GCADGEESDC LTEYEEDAGP DCSRDEGGSP EGASPSTASE MEEEKSILRQ 1350
RRCLPQEPPG SATDA 1365
Length:1,365
Mass (Da):149,750
Last modified:December 21, 2004 - v1
Checksum:iA700733C7A74EB39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857832 mRNA. Translation: CAH90087.1.
RefSeqiNP_001124999.1. NM_001131527.1.
UniGeneiPab.7195.

Genome annotation databases

GeneIDi100453292.
KEGGipon:100453292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857832 mRNA. Translation: CAH90087.1 .
RefSeqi NP_001124999.1. NM_001131527.1.
UniGenei Pab.7195.

3D structure databases

ProteinModelPortali Q5RDS0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100453292.
KEGGi pon:100453292.

Organism-specific databases

CTDi 10908.

Phylogenomic databases

HOVERGENi HBG053067.
InParanoidi Q5RDS0.
KOi K14676.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPLPL6_PONAB
AccessioniPrimary (citable) accession number: Q5RDS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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