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Q5RDP0 (SPYA_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--pyruvate aminotransferase
Short name=SPT
EC=2.6.1.51
Alternative name(s):
Alanine--glyoxylate aminotransferase
Short name=AGT
EC=2.6.1.44
Gene names
Name:AGXT
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.

L-alanine + glyoxylate = pyruvate + glycine.

Cofactor

Pyridoxal phosphate By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Serine--pyruvate aminotransferase
PRO_0000260250

Regions

Motif390 – 3923Microbody targeting signal

Sites

Binding site3601Substrate By similarity

Amino acid modifications

Modified residue2091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RDP0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: DF2E465AE6968493

FASTA39243,155
        10         20         30         40         50         60 
MASHKLLVHP PKALLKPLSI PNRLLLGPGP SNLAPRIMAA GGLQIIGPMS KDMYQIMDEI 

        70         80         90        100        110        120 
KEGIRYVFQT RNPLTLVISG SAHCALEAAL VNVLEPGDSF LVGANGIWGQ RAVDIGERMG 

       130        140        150        160        170        180 
ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL LFLTHGESST GVLQPLDGFG ELCHRYKCLL 

       190        200        210        220        230        240 
LVDSVVSVGG TPVYMDQQGI DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF 

       250        260        270        280        290        300 
YLDIKWLANF WGCDDQPRMY HHTIPIISLY SLRESLALIA EQGLENSWRK HREAAAYLHG 

       310        320        330        340        350        360 
RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVM DHFDIEIMGG LGPPTGKVLR 

       370        380        390 
IGLLGYNATH ENVDRVTEAL RAALQHCPKK KL

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR857864 mRNA. Translation: CAH90117.1.
RefSeqNP_001125018.1. NM_001131546.1.
UniGenePab.14752.

3D structure databases

HSSPHSSP built from PDB template 1H0C based on UniProtKB P21549.
ProteinModelPortalQ5RDP0.
SMRQ5RDP0. Positions 4-390.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100171897.
KEGGpon:100171897.

Organism-specific databases

CTD189.

Phylogenomic databases

HOVERGENHBG006907.

Family and domain databases

InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00830.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000524. SPT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPYA_PONAB
AccessionPrimary (citable) accession number: Q5RDP0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 21, 2004
Last modified: November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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