Reviewed, UniProtKB/Swiss-Prot Q5RDP0 (SPYA_PONAB)

Names and origin

Protein names

Recommended name:
    Serine--pyruvate aminotransferase
      Short name=SPT
    EC=2.6.1.51
Alternative name(s):
    Alanine--glyoxylate aminotransferase
      Short name=AGT
    EC=2.6.1.44

Gene names

Name:

AGXT

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. L-alanine + glyoxylate = pyruvate + glycine.
Cofactor	Pyridoxal phosphate By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alanine-glyoxylate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro serine-pyruvate transaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Serine--pyruvate aminotransferase		PRO_0000260250
Regions
	Motif	390 – 392	3	Microbody targeting signal
Sites
	Binding site	360	1	Substrate By similarity
Amino acid modifications
	Modified residue	209	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RDP0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: DF2E465AE6968493	FASTA	392	43,155
	10 20 30 40 50 60 MASHKLLVHP PKALLKPLSI PNRLLLGPGP SNLAPRIMAA GGLQIIGPMS KDMYQIMDEI 70 80 90 100 110 120 KEGIRYVFQT RNPLTLVISG SAHCALEAAL VNVLEPGDSF LVGANGIWGQ RAVDIGERMG 130 140 150 160 170 180 ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL LFLTHGESST GVLQPLDGFG ELCHRYKCLL 190 200 210 220 230 240 LVDSVVSVGG TPVYMDQQGI DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF 250 260 270 280 290 300 YLDIKWLANF WGCDDQPRMY HHTIPIISLY SLRESLALIA EQGLENSWRK HREAAAYLHG 310 320 330 340 350 360 RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVM DHFDIEIMGG LGPPTGKVLR 370 380 390 IGLLGYNATH ENVDRVTEAL RAALQHCPKK KL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857864 mRNA. Translation: CAH90117.1.
RefSeq	NP_001125018.1.
UniGene	Pab.14752
3D structure databases
HSSP	HSSP built from PDB template 1H0C based on UniProtKB P21549.
SMR	Q5RDP0. Positions 4-390.
ModBase	Search...
Genome annotation databases
GeneID	100171897.
Organism-specific databases
CTD	100171897.
Phylogenomic databases
HOVERGEN	Q5RDP0.
Enzyme and pathway databases
BRENDA	2.6.1.44. 269192. 2.6.1.51. 269192.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR020578. Aminotrans_V_PyrdxlP_BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PROSITE	PS00595. AA_TRANSFER_CLASS_5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPYA_PONAB

Accession

Primary (citable) accession number: Q5RDP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)