Q5RDJ5 (CYB5B_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b5 type B

Alternative name(s):
Cytochrome b5 outer mitochondrial membrane isoform

Gene names

Name:	CYB5B
Synonyms:	CYB5M

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases By similarity.
Subunit structure	Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2 By similarity.
Subcellular location	Mitochondrion outer membrane By similarity.
Sequence similarities	Belongs to the cytochrome b5 family. Contains 1 cytochrome b5 heme-binding domain.
Sequence caution	The sequence CAH90162.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 11	11	By similarity		PRO_0000006475
	Chain	12 – 146	135	Cytochrome b5 type B		PRO_0000006476
Regions
	Transmembrane	118 – 140	23	Helical; Potential
	Domain	20 – 96	77	Cytochrome b5 heme-binding
Sites
	Metal binding	55	1	Iron (heme axial ligand) By similarity
	Metal binding	79	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	30	1	N6-acetyllysine By similarity
	Modified residue	33	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RDJ5 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 2FF7703D00E27E18	FASTA	146	16,387
	10 20 30 40 50 60 MATAEASGSD GKGQEVETSV TYYRMEEVAK RNSLKELWLV IHGRVYDVTR FLNEHPGGEE 70 80 90 100 110 120 VLLEQAGVDA SESFEDVGHS SDAREMLKQY YIGDIHPSDL KPENGSKDPS KNDTCKSCWA 130 140 YWILPIIGAV LLGFLYRYYT PESKSS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857913 mRNA. Translation: CAH90162.1. Different initiation.
RefSeq	NP_001125049.1. NM_001131577.1.
UniGene	Pab.19345.
3D structure databases
ProteinModelPortal	Q5RDJ5.
SMR	Q5RDJ5. Positions 19-102.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000008820; ENSPPYP00000008474; ENSPPYG00000007506. ENSPPYT00000008821; ENSPPYP00000008475; ENSPPYG00000007506.
GeneID	100171930.
KEGG	pon:100171930.
Organism-specific databases
CTD	80777.
Phylogenomic databases
HOVERGEN	HBG002653.
InParanoid	Q5RDJ5.
OrthoDB	EOG40ZR00.
Family and domain databases
InterPro	IPR023271. Aquaporin-like. IPR001199. Cyt_B5. IPR018506. Cyt_B5_heme-BS. [Graphical view]
Gene3D	G3DSA:3.10.120.10. Cyt_B5. 1 hit. G3DSA:1.20.1080.10. MIP. 1 hit.
Pfam	PF00173. Cyt-b5. 1 hit. [Graphical view]
PRINTS	PR00363. CYTOCHROMEB5.
SUPFAM	SSF55856. Cyt_B5. 1 hit.
PROSITE	PS00191. CYTOCHROME_B5_1. 1 hit. PS50255. CYTOCHROME_B5_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYB5B_PONAB

Accession

Primary (citable) accession number: Q5RDJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	June 28, 2011
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program