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Protein

Nuclear envelope integral membrane protein 1

Gene

NEMP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear envelope integral membrane protein 1
Gene namesi
Name:NEMP1
Synonyms:TMEM194A
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000034366044 – 444Nuclear envelope integral membrane protein 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei368PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation may regulate its interaction with RAN-GTP.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Interacts with RAN-GTP.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005329.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 297A; required for its colocalization with lamins at the nuclear envelopeBy similarityAdd BLAST112
Regioni336 – 444Required for nuclear localizationBy similarityAdd BLAST109
Regioni336 – 405B; required for interaction with RAN-GTPBy similarityAdd BLAST70

Domaini

The transmembrane domains are required and sufficient for its oligomerization.By similarity

Sequence similaritiesi

Belongs to the NEMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3817. Eukaryota.
ENOG410ZZKM. LUCA.
HOGENOMiHOG000122573.
HOVERGENiHBG052180.
InParanoidiQ5RDB4.

Family and domain databases

InterProiView protein in InterPro
IPR019358. NEMP_fam.
PfamiView protein in Pfam
PF10225. NEMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RDB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGMKVAVS PAVGPGPWGS GVGGGGTVRL LLILSGCLVY GTAEIDVNVV
60 70 80 90 100
MLQESQVCEK RASQQFCYTN VLIPKWHDIW TRIQIRVNSS KLVRVTQVEN
110 120 130 140 150
EQKLKELEQF SIWNFFSSFL KEKLNDTYVN VGLYSTKTCL KVEIIEKDTK
160 170 180 190 200
YSVIVIRRFD PKLFLVFLLG LMLFFCGDLL SRSQIFYYST GMSVGIVASL
210 220 230 240 250
LIIIFILSKF MPKKSPIYVI LVGGWSFSLY LIQLVFKNLQ EIWRCYWQYL
260 270 280 290 300
LSYILTVGFM SFAVCYKYGP LENERSIDLL TWTLQLMGLC FMYSGIQIPH
310 320 330 340 350
IALAIIIIAL CTKNLEYPIQ WLYITYRKVC KAAEKPVPPR LLTEEEYRIQ
360 370 380 390 400
GEVETRKALE ELREFCNSPD CSAWKTVSRI QSPKRFADFV EGSSHLTPNE
410 420 430 440
VSVHEQEYGL GSIIAQDEIY EEASSEEEDS YSRCPAITQN NFLT
Length:444
Mass (Da):50,724
Last modified:December 21, 2004 - v1
Checksum:i777F73250B8BD3E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858000 mRNA. Translation: CAH90243.1.
RefSeqiNP_001125105.1. NM_001131633.1.
UniGeneiPab.12011.

Genome annotation databases

GeneIDi100431552.
KEGGipon:100431552.

Similar proteinsi

Entry informationi

Entry nameiNEMP1_PONAB
AccessioniPrimary (citable) accession number: Q5RDB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 21, 2004
Last modified: May 10, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families