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Protein

Cleavage stimulation factor subunit 2

Gene

CSTF2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 2
Alternative name(s):
CF-1 64 kDa subunit
Cleavage stimulation factor 64 kDa subunit
Short name:
CSTF 64 kDa subunit
Short name:
CstF-64
Gene namesi
Name:CSTF2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815331 – 577Cleavage stimulation factor subunit 2Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei308Omega-N-methylarginineBy similarity1
Modified residuei468Omega-N-methylarginineBy similarity1
Modified residuei475Omega-N-methylarginineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei524PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells (By similarity). Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000022995

Structurei

3D structure databases

ProteinModelPortaliQ5RDA3
SMRiQ5RDA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94RRMPROSITE-ProRule annotationAdd BLAST79
Repeati410 – 4141; approximate5
Repeati415 – 41925
Repeati420 – 42435
Repeati425 – 4294; approximate5
Repeati430 – 4345; approximate5
Repeati435 – 43965
Repeati440 – 44475
Repeati445 – 44985
Repeati450 – 45495
Repeati455 – 45910; approximate5
Repeati460 – 464115
Repeati465 – 46912; approximate5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 248Interactions with CSTF3 and SYMPKBy similarityAdd BLAST141
Regioni410 – 46912 X 5 AA tandem repeats of M-E-A-R-[AG]Add BLAST60
Regioni514 – 577Interaction with RPO2TC1By similarityAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 409Gly/Pro-richAdd BLAST212
Compositional biasi470 – 526Gly/Pro-richAdd BLAST57

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0108 Eukaryota
ENOG410XQBV LUCA
HOVERGENiHBG051145
InParanoidiQ5RDA3
KOiK14407

Family and domain databases

Gene3Di1.10.20.70, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR033105 CSTF2
IPR038192 CSTF2_C_sf
IPR025742 CSTF2_hinge
IPR026896 CSTF_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23139:SF57 PTHR23139:SF57, 1 hit
PfamiView protein in Pfam
PF14327 CSTF2_hinge, 1 hit
PF14304 CSTF_C, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RDA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD
60 70 80 90 100
RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE
110 120 130 140 150
LKSLGTGAPV IESPYGETIS PEDAPESISK AVASLPPEQM FELMKQMKLC
160 170 180 190 200
VQNSPQEARN MLLQNPQLAY ALLQAQVVMR IVDPEIALKI LHRQTNIPTL
210 220 230 240 250
IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN GAPPLMQASM
260 270 280 290 300
QGGVPAPGQI PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQVPMQ
310 320 330 340 350
DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE VEPRGYLGPP
360 370 380 390 400
HQGPPMHHVP GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD
410 420 430 440 450
GRGGRDPRGI DARGMEARAM EARGLDARGL EARAMEARAM EARAMEARAM
460 470 480 490 500
EARAMEVRGM EARGMDTRGP VPGPRGPIPS GMQGPSPINM GAVVPQGSRQ
510 520 530 540 550
VPVMQGTGLQ GASIQGGSQP GGFSPGQNQV TPQDHEKAAL IMQVLQLTAD
560 570
QIAMLPPEQR QSILILKEQI QKSTGAP
Length:577
Mass (Da):60,923
Last modified:December 21, 2004 - v1
Checksum:i428F2FFDBDE8DAA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858012 mRNA Translation: CAH90254.1
RefSeqiNP_001125111.1, NM_001131639.2
UniGeneiPab.17359

Genome annotation databases

GeneIDi100171993
KEGGipon:100171993

Similar proteinsi

Entry informationi

Entry nameiCSTF2_PONAB
AccessioniPrimary (citable) accession number: Q5RDA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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