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Protein

Mitochondrial glutamate carrier 1

Gene

SLC25A22

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 1
Short name:
GC-1
Alternative name(s):
Glutamate/H(+) symporter 1
Solute carrier family 25 member 22
Gene namesi
Name:SLC25A22
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316531 – 323Mitochondrial glutamate carrier 1Add BLAST323

Structurei

3D structure databases

ProteinModelPortaliQ5RD81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 93Solcar 1Add BLAST88
Repeati101 – 214Solcar 2Add BLAST114
Repeati223 – 312Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG039469
InParanoidiQ5RD81
KOiK15107

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q5RD81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYTSMS
60 70 80 90 100
DCLIKTIRSE GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RHQLSKDGQK
110 120 130 140 150
LTLLKEMLAG CGAGTCQVIV TTPMEMLKIQ LQDAGRIAAQ RKILAAQGQL
160 170 180 190 200
SAQGGAQPSV EAPAAPRPTA IQLTRDLLRS RGIAGLYKGL GATLLRDVPL
210 220 230 240 250
SVVYFPLFAN LNQLGRPASE EKSPFYVSFL AGCVAGSAAA VAVNPCDVVK
260 270 280 290 300
TRLQSLQRGV NEDTYSGILD CARKILRHEG PSAFLKGAYC RALVIAPLFG
310 320
IAQVVYFLGI AESLLGLLQD PQA
Length:323
Mass (Da):34,494
Last modified:December 21, 2004 - v1
Checksum:iA0E6590AB6002793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858035 mRNA Translation: CAH90276.1
RefSeqiNP_001125123.1, NM_001131651.1
UniGeneiPab.8758

Genome annotation databases

GeneIDi100172007
KEGGipon:100172007

Similar proteinsi

Entry informationi

Entry nameiGHC1_PONAB
AccessioniPrimary (citable) accession number: Q5RD81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health