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Protein

Probable E3 ubiquitin-protein ligase HECTD2

Gene

HECTD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei744 – 7441Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HECTD2 (EC:6.3.2.-)
Alternative name(s):
HECT domain-containing protein 2
Gene namesi
Name:HECTD2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 776776Probable E3 ubiquitin-protein ligase HECTD2PRO_0000240853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000002871.

Structurei

3D structure databases

ProteinModelPortaliQ5RD78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini437 – 776340HECTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG081596.
InParanoidiQ5RD78.
KOiK12232.

Family and domain databases

InterProiIPR000569. HECT_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RD78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAVRVPSP ATPLVVAAAA PEERKGKESE REKLPPIVSA GAGATAGLDR
60 70 80 90 100
GAKGQISTFS SFISAVSPKK EAAENRSSPA HLVFPNIKNV RDQPPICLDV
110 120 130 140 150
RQKQRTSMDA SSSEMKAPVL PEPIHPIQPK TVKDFQEDVE KVKSSGDWKA
160 170 180 190 200
VHDFYLTTFD SFPELNAAFK KDATASFNTI EDSGINAKFV NAVYDTLLNT
210 220 230 240 250
PQDIQKTVLK GIINSLLREW KGPRTKDDLR AYFVLLQNPQ FNNTSTYVIY
260 270 280 290 300
AHLLRQIATL VEADHHFLVH WFKRLSQKRF KQLVERLLQF ISLRLFPAKP
310 320 330 340 350
EEFPPVTKCS WWIPSAAKVL ALLNTANNLV HPPLIPYTDF YNSTLDHIDL
360 370 380 390 400
MEEYHTWQNF GNSHRFSFCQ YPFVISVAAK KIIIQRDSEQ QMINIARQSL
410 420 430 440 450
VDKVSRRQRP DMNMLFLNMK VRRTHLVSDS LDELTRKRAD LKKKLKVTFV
460 470 480 490 500
GEAGLDMGGL TKEWFLLLIR QIFHPDYGMF TYHKDSHCHW FSSFKCDNYS
510 520 530 540 550
EFRLVGILMG LAVYNSITLD IRFPPCCYKK LLSPPIIPSD QNIPVGICSV
560 570 580 590 600
TVDDLCQIMP ELAHGLSELL SHEGNVEEDF YSTFQVFQEE FGIIKSYNLK
610 620 630 640 650
PGGDKISVTN QNRKEYVQLY TDFLLNKSIY KQFAAFYYGF HSVCASNALM
660 670 680 690 700
LLRPEEVEIL VCGSPDLDMH ALQRSTQYDG YAKTDLTIKY FWDVVLGFPL
710 720 730 740 750
DLQKKLLHFT TGSDRVPVGG MADLNFKISK NETSTNCLPV AHTCFNQLCL
760 770
PPYKSKKDLK QKLIIGISNS EGFGLE
Length:776
Mass (Da):88,142
Last modified:December 21, 2004 - v1
Checksum:iB1B5C8F349CD7A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858038 mRNA. Translation: CAH90279.1.
RefSeqiNP_001125126.1. NM_001131654.1.
UniGeneiPab.7272.

Genome annotation databases

GeneIDi100172010.
KEGGipon:100172010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858038 mRNA. Translation: CAH90279.1.
RefSeqiNP_001125126.1. NM_001131654.1.
UniGeneiPab.7272.

3D structure databases

ProteinModelPortaliQ5RD78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000002871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172010.
KEGGipon:100172010.

Organism-specific databases

CTDi143279.

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG081596.
InParanoidiQ5RD78.
KOiK12232.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR000569. HECT_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHECD2_PONAB
AccessioniPrimary (citable) accession number: Q5RD78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.