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Q5RD73

- DUS3_PONAB

UniProt

Q5RD73 - DUS3_PONAB

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Protein
Dual specificity protein phosphatase 3
Gene
DUSP3
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei124 – 1241Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. MAP kinase phosphatase activity Source: Ensembl
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
  3. protein tyrosine/serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  2. negative regulation of JNK cascade Source: Ensembl
  3. negative regulation of T cell activation Source: Ensembl
  4. negative regulation of T cell receptor signaling pathway Source: Ensembl
  5. positive regulation of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Vaccinia H1-related phosphatase
Short name:
VHR
Gene namesi
Name:DUSP3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 17

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. immunological synapse Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Dual specificity protein phosphatase 3
PRO_0000094797Add
BLAST

Proteomic databases

PRIDEiQ5RD73.

Interactioni

Subunit structurei

Interacts with VRK3, which seems to activate it's phosphatase activity By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RD73.
SMRiQ5RD73. Positions 7-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 16971Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074474.
HOVERGENiHBG001524.
InParanoidiQ5RD73.
KOiK17614.
OMAiPCNEVIP.
OrthoDBiEOG7CZK7N.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RD73-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK    50
LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA 100
YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA 150
LSIVRQNREI GPNDGFLAQL CQLNDRLAKE GKLKP 185
Length:185
Mass (Da):20,478
Last modified:December 21, 2004 - v1
Checksum:iC1045DD9B226FD94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858043 mRNA. Translation: CAH90284.1.
RefSeqiNP_001125129.1. NM_001131657.1.
UniGeneiPab.6924.

Genome annotation databases

EnsembliENSPPYT00000009767; ENSPPYP00000009390; ENSPPYG00000008353.
GeneIDi100172013.
KEGGipon:100172013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858043 mRNA. Translation: CAH90284.1 .
RefSeqi NP_001125129.1. NM_001131657.1.
UniGenei Pab.6924.

3D structure databases

ProteinModelPortali Q5RD73.
SMRi Q5RD73. Positions 7-185.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q5RD73.

Proteomic databases

PRIDEi Q5RD73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000009767 ; ENSPPYP00000009390 ; ENSPPYG00000008353 .
GeneIDi 100172013.
KEGGi pon:100172013.

Organism-specific databases

CTDi 1845.

Phylogenomic databases

GeneTreei ENSGT00550000074474.
HOVERGENi HBG001524.
InParanoidi Q5RD73.
KOi K17614.
OMAi PCNEVIP.
OrthoDBi EOG7CZK7N.
TreeFami TF105128.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDUS3_PONAB
AccessioniPrimary (citable) accession number: Q5RD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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