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Q5RD73

- DUS3_PONAB

UniProt

Q5RD73 - DUS3_PONAB

Protein

Dual specificity protein phosphatase 3

Gene

DUSP3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei124 – 1241Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase phosphatase activity Source: Ensembl
    2. protein tyrosine/serine/threonine phosphatase activity Source: Ensembl
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    2. negative regulation of JNK cascade Source: Ensembl
    3. negative regulation of T cell activation Source: Ensembl
    4. negative regulation of T cell receptor signaling pathway Source: Ensembl
    5. positive regulation of mitotic cell cycle Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 3 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Vaccinia H1-related phosphatase
    Short name:
    VHR
    Gene namesi
    Name:DUSP3
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 17

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. immunological synapse Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Dual specificity protein phosphatase 3PRO_0000094797Add
    BLAST

    Proteomic databases

    PRIDEiQ5RD73.

    Interactioni

    Subunit structurei

    Interacts with VRK3, which seems to activate it's phosphatase activity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RD73.
    SMRiQ5RD73. Positions 7-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini99 – 16971Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00550000074474.
    HOVERGENiHBG001524.
    InParanoidiQ5RD73.
    KOiK17614.
    OMAiPCNEVIP.
    OrthoDBiEOG7CZK7N.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RD73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK    50
    LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA 100
    YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA 150
    LSIVRQNREI GPNDGFLAQL CQLNDRLAKE GKLKP 185
    Length:185
    Mass (Da):20,478
    Last modified:December 21, 2004 - v1
    Checksum:iC1045DD9B226FD94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858043 mRNA. Translation: CAH90284.1.
    RefSeqiNP_001125129.1. NM_001131657.1.
    UniGeneiPab.6924.

    Genome annotation databases

    EnsembliENSPPYT00000009767; ENSPPYP00000009390; ENSPPYG00000008353.
    GeneIDi100172013.
    KEGGipon:100172013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858043 mRNA. Translation: CAH90284.1 .
    RefSeqi NP_001125129.1. NM_001131657.1.
    UniGenei Pab.6924.

    3D structure databases

    ProteinModelPortali Q5RD73.
    SMRi Q5RD73. Positions 7-185.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q5RD73.

    Proteomic databases

    PRIDEi Q5RD73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000009767 ; ENSPPYP00000009390 ; ENSPPYG00000008353 .
    GeneIDi 100172013.
    KEGGi pon:100172013.

    Organism-specific databases

    CTDi 1845.

    Phylogenomic databases

    GeneTreei ENSGT00550000074474.
    HOVERGENi HBG001524.
    InParanoidi Q5RD73.
    KOi K17614.
    OMAi PCNEVIP.
    OrthoDBi EOG7CZK7N.
    TreeFami TF105128.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDUS3_PONAB
    AccessioniPrimary (citable) accession number: Q5RD73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3