ID   KHK_PONAB               Reviewed;         297 AA.
AC   Q5RD71;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Ketohexokinase;
DE            EC=2.7.1.3;
DE   AltName: Full=Hepatic fructokinase;
GN   Name=KHK;
OS   Pongo abelii (Sumatran orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose = ADP + D-fructose 1-
CC       phosphate.
CC   -!- ENZYME REGULATION: Requires potassium. Inhibition by ADP (By
CC       similarity).
CC   -!- PATHWAY: Carbohydrate metabolism; fructose metabolism.
CC   -!- SUBUNIT: Dimer of A-A, A-C or C-C (Probable).
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase pfkB family.
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DR   EMBL; CR858045; CAH90286.1; -; Transcribed_RNA.
DR   SMR; Q5RD71; 5-297.
DR   HOVERGEN; Q5RD71; -.
DR   BRENDA; 2.7.1.3; 269192.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004454; F:ketohexokinase activity; IEA:EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR011611; Carb/pur_kinase.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   Pfam; PF00294; PfkB; 2.
DR   PROSITE; PS00583; PFKB_KINASES_1; FALSE_NEG.
DR   PROSITE; PS00584; PFKB_KINASES_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Transferase.
FT   CHAIN         1    297       Ketohexokinase.
FT                                /FTId=PRO_0000080090.
FT   MOD_RES     168    168       Phosphoserine (By similarity).
SQ   SEQUENCE   297 AA;  32476 MW;  049C7C1FA74DEF16 CRC64;
     MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM
     GSMAPGHVAF LVADFRRRGV DVSQVAWQSK GDTPSSCCII NNSNGNRTIV LHDTSLPDVS
     ATDFEKVDLT QFKWIHIEGR NASEQVKMLQ RIDTHNTRQP PEQKIRVSVE VEKPQEELFQ
     LFGYGDVVFV SKDVAKHLGF QSAEAALRGL YGRVRKGAVL VCAWAEEGAD ALGPDDKLFH
     SDAFPPPRVV DTLGAGDTFN ASVIFSLSQG RSMQEALRFG CQVAGKKCGL QGFDGIV
//