Reviewed, UniProtKB/Swiss-Prot Q5RD71 (KHK_PONAB)

Names and origin

Protein names

Recommended name:
    Ketohexokinase
    EC=2.7.1.3
Alternative name(s):
    Hepatic fructokinase

Gene names

Name:

KHK

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-fructose = ADP + D-fructose 1-phosphate.
Enzyme regulation	Requires potassium. Inhibition by ADP By similarity.
Pathway	Carbohydrate metabolism; fructose metabolism.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ketohexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Ketohexokinase		PRO_0000080090
Regions
	Nucleotide binding	254 – 257	4	ATP By similarity
Sites
	Binding site	15	1	D-fructose By similarity
	Binding site	41	1	D-fructose; via amide nitrogen By similarity
	Binding site	42	1	D-fructose By similarity
	Binding site	45	1	D-fructose By similarity
	Binding site	107	1	ATP By similarity
	Binding site	257	1	D-fructose By similarity
Amino acid modifications
	Modified residue	168	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RD71-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 049C7C1FA74DEF16	FASTA	297	32,476
	10 20 30 40 50 60 MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 70 80 90 100 110 120 GSMAPGHVAF LVADFRRRGV DVSQVAWQSK GDTPSSCCII NNSNGNRTIV LHDTSLPDVS 130 140 150 160 170 180 ATDFEKVDLT QFKWIHIEGR NASEQVKMLQ RIDTHNTRQP PEQKIRVSVE VEKPQEELFQ 190 200 210 220 230 240 LFGYGDVVFV SKDVAKHLGF QSAEAALRGL YGRVRKGAVL VCAWAEEGAD ALGPDDKLFH 250 260 270 280 290 SDAFPPPRVV DTLGAGDTFN ASVIFSLSQG RSMQEALRFG CQVAGKKCGL QGFDGIV

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR858045 Transcribed RNA. Translation: CAH90286.1.
UniGene	Pab.14763
3D structure databases
SMR	Q5RD71. Positions 3-297.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5RD71.
Enzyme and pathway databases
BRENDA	2.7.1.3. 269192.
Family and domain databases
InterPro	IPR011611. Carb/pur_kinase. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHK_PONAB

Accession

Primary (citable) accession number: Q5RD71

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)