Reviewed, UniProtKB/Swiss-Prot Q5RD31 (NQO1_PONAB)

Names and origin

Protein names

Recommended name:
    NAD(P)H dehydrogenase [quinone] 1
    EC=1.6.5.2
Alternative name(s):
    Quinone reductase 1
    NAD(P)H:quinone oxidoreductase 1
      Short name=QR1
    DT-diaphorase
      Short name=DTD
    Azoreductase
    Phylloquinone reductase
    Menadione reductase

Gene names

Name:

NQO1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis By similarity.
Catalytic activity	NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.
Cofactor	FAD By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD(P)H dehydrogenase (quinone) family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)H dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	NAD(P)H dehydrogenase [quinone] 1		PRO_0000071624
Regions
	Nucleotide binding	18 – 19	2	FAD By similarity
	Nucleotide binding	104 – 107	4	FAD By similarity
	Nucleotide binding	148 – 151	4	FAD By similarity
	Region	126 – 128	3	Substrate binding By similarity
Sites
	Binding site	12	1	FAD By similarity
	Binding site	67	1	FAD By similarity
	Binding site	156	1	FAD By similarity
	Binding site	201	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RD31-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 87588D65B8E92A67	FASTA	274	30,940
	10 20 30 40 50 60 MVGRRALIVL AHSERTSFNY AMKEAAVAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL 70 80 90 100 110 120 KDPENFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV 130 140 150 160 170 180 FVGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC 190 200 210 220 230 240 GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK 250 260 270 KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR858087 mRNA. Translation: CAH90326.1.
RefSeq	NP_001125152.1.
UniGene	Pab.19304
3D structure databases
SMR	Q5RD31. Positions 2-274.
ModBase	Search...
Genome annotation databases
GeneID	100172039.
Phylogenomic databases
HOVERGEN	Q5RD31.
OMA	Q5RD31. VERVYAY.
Enzyme and pathway databases
BRENDA	1.6.5.2. 269192.
Family and domain databases
InterPro	IPR003680. Flavodoxin_fold. [Graphical view]
Pfam	PF02525. Flavodoxin_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NQO1_PONAB

Accession

Primary (citable) accession number: Q5RD31

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)