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Protein

NAD(P)H dehydrogenase [quinone] 1

Gene

NQO1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.By similarity

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121FADBy similarity
Binding sitei67 – 671FADBy similarity
Binding sitei156 – 1561FADBy similarity
Binding sitei201 – 2011FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 192FADBy similarity
Nucleotide bindingi104 – 1074FADBy similarity
Nucleotide bindingi148 – 1514FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6506-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)
Alternative name(s):
Azoreductase
DT-diaphorase
Short name:
DTD
Menadione reductase
NAD(P)H:quinone oxidoreductase 1
Phylloquinone reductase
Quinone reductase 1
Short name:
QR1
Gene namesi
Name:NQO1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 274273NAD(P)H dehydrogenase [quinone] 1PRO_0000071624Add
BLAST

Proteomic databases

PRIDEiQ5RD31.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008478.

Structurei

3D structure databases

ProteinModelPortaliQ5RD31.
SMRiQ5RD31. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1283Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKWF. Eukaryota.
COG2249. LUCA.
GeneTreeiENSGT00440000033410.
HOVERGENiHBG029104.
InParanoidiQ5RD31.
KOiK00355.
OMAiYDKGPFQ.
OrthoDBiEOG7CZK6F.
TreeFamiTF300296.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RD31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRRALIVL AHSERTSFNY AMKEAAVAAL KKKGWEVVES DLYAMNFNPI
60 70 80 90 100
ISRKDITGKL KDPENFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF
110 120 130 140 150
QFPLQWFGVP AILKGWFERV FVGEFAYTYA AMYDKGPFRS KKAVLSITTG
160 170 180 190 200
GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA
210 220 230 240 250
RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK
260 270
KFGLSVGHHL GKSIPTDNQI KARK
Length:274
Mass (Da):30,940
Last modified:December 21, 2004 - v1
Checksum:i87588D65B8E92A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858087 mRNA. Translation: CAH90326.1.
RefSeqiNP_001125152.1. NM_001131680.1.

Genome annotation databases

EnsembliENSPPYT00000008824; ENSPPYP00000008478; ENSPPYG00000007508.
GeneIDi100172039.
KEGGipon:100172039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858087 mRNA. Translation: CAH90326.1.
RefSeqiNP_001125152.1. NM_001131680.1.

3D structure databases

ProteinModelPortaliQ5RD31.
SMRiQ5RD31. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008478.

Proteomic databases

PRIDEiQ5RD31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000008824; ENSPPYP00000008478; ENSPPYG00000007508.
GeneIDi100172039.
KEGGipon:100172039.

Organism-specific databases

CTDi1728.

Phylogenomic databases

eggNOGiENOG410IKWF. Eukaryota.
COG2249. LUCA.
GeneTreeiENSGT00440000033410.
HOVERGENiHBG029104.
InParanoidiQ5RD31.
KOiK00355.
OMAiYDKGPFQ.
OrthoDBiEOG7CZK6F.
TreeFamiTF300296.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6506-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiNQO1_PONAB
AccessioniPrimary (citable) accession number: Q5RD31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.