Q5RD01 (CDK18_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 18
EC=2.7.11.22

Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3

Gene names

Name:	CDK18
Synonyms:	PCTAIRE3, PCTK3

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in signal transduction cascades in terminally differentiated cells By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence CAH90356.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Cyclin-dependent kinase 18		PRO_0000086492
Regions
	Domain	142 – 423	282	Protein kinase
	Nucleotide binding	148 – 156	9	ATP By similarity
Sites
	Active site	263	1	Proton acceptor By similarity
	Binding site	171	1	ATP By similarity
Amino acid modifications
	Modified residue	12	1	Phosphoserine By similarity
	Modified residue	72	1	Phosphoserine By similarity
	Modified residue	87	1	Phosphoserine By similarity
	Modified residue	96	1	Phosphoserine By similarity
	Modified residue	115	1	Phosphoserine By similarity
	Modified residue	130	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RD01 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: 45C53C87B8539CFF	FASTA	472	54,224
	10 20 30 40 50 60 MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR DPLQECSTFS 70 80 90 100 110 120 PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD IRLPQEFLQK LQMESPDLPK 130 140 150 160 170 180 PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 190 200 210 220 230 240 APCTAIREVS LLKNLKHANI VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV 250 260 270 280 290 300 KIFMFQLLRG LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 310 320 330 340 350 360 TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL IFRLLGTPTE 370 380 390 400 410 420 ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL SSLLLYESKS RMSAEAALSH 430 440 450 460 470 PYFRSLGERV HQLEDTASIF SLKEIQLQKD PGYRGLAFQQ PGRGKNRRQS IF

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR858117 mRNA. Translation: CAH90356.1. Different initiation.
RefSeq	NP_001127275.1. NM_001133803.1.
UniGene	Pab.11890.
3D structure databases
ProteinModelPortal	Q5RD01.
SMR	Q5RD01. Positions 141-424.
ModBase	Search...
Proteomic databases
PRIDE	Q5RD01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000000344; ENSPPYP00000000327; ENSPPYG00000000304. ENSPPYT00000000345; ENSPPYP00000000328; ENSPPYG00000000304.
GeneID	100174332.
KEGG	pon:100174332.
Organism-specific databases
CTD	5129.
Phylogenomic databases
GeneTree	ENSGT00600000083998.
HOVERGEN	HBG014652.
InParanoid	Q5RD01.
KO	K15596.
OrthoDB	EOG47D9FX.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK18_PONAB

Accession

Primary (citable) accession number: Q5RD01

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program