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Q5RD01

- CDK18_PONAB

UniProt

Q5RD01 - CDK18_PONAB

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Protein
Cyclin-dependent kinase 18
Gene
CDK18, PCTAIRE3, PCTK3
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711ATP By similarity
Active sitei263 – 2631Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 1569ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 18 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 18
    PCTAIRE-motif protein kinase 3
    Serine/threonine-protein kinase PCTAIRE-3
    Gene namesi
    Name:CDK18
    Synonyms:PCTAIRE3, PCTK3
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Cyclin-dependent kinase 18
    PRO_0000086492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphoserine By similarity
    Modified residuei72 – 721Phosphoserine By similarity
    Modified residuei87 – 871Phosphoserine By similarity
    Modified residuei96 – 961Phosphoserine By similarity
    Modified residuei115 – 1151Phosphoserine By similarity
    Modified residuei130 – 1301Phosphoserine By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5RD01.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RD01.
    SMRiQ5RD01. Positions 141-424.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 423282Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00600000083998.
    HOVERGENiHBG014652.
    InParanoidiQ5RD01.
    KOiK15596.
    OrthoDBiEOG7966H8.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RD01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR    50
    DPLQECSTFS PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD 100
    IRLPQEFLQK LQMESPDLPK PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE 150
    GTYATVFKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKNLKHANI 200
    VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV KIFMFQLLRG 250
    LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300
    TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL 350
    IFRLLGTPTE ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL 400
    SSLLLYESKS RMSAEAALSH PYFRSLGERV HQLEDTASIF SLKEIQLQKD 450
    PGYRGLAFQQ PGRGKNRRQS IF 472
    Length:472
    Mass (Da):54,224
    Last modified:February 15, 2005 - v2
    Checksum:i45C53C87B8539CFF
    GO

    Sequence cautioni

    The sequence CAH90356.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858117 mRNA. Translation: CAH90356.1. Different initiation.
    RefSeqiNP_001127275.1. NM_001133803.1.
    UniGeneiPab.11890.

    Genome annotation databases

    EnsembliENSPPYT00000000344; ENSPPYP00000000327; ENSPPYG00000000304.
    ENSPPYT00000000345; ENSPPYP00000000328; ENSPPYG00000000304.
    GeneIDi100174332.
    KEGGipon:100174332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858117 mRNA. Translation: CAH90356.1 . Different initiation.
    RefSeqi NP_001127275.1. NM_001133803.1.
    UniGenei Pab.11890.

    3D structure databases

    ProteinModelPortali Q5RD01.
    SMRi Q5RD01. Positions 141-424.
    ModBasei Search...

    Proteomic databases

    PRIDEi Q5RD01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000000344 ; ENSPPYP00000000327 ; ENSPPYG00000000304 .
    ENSPPYT00000000345 ; ENSPPYP00000000328 ; ENSPPYG00000000304 .
    GeneIDi 100174332.
    KEGGi pon:100174332.

    Organism-specific databases

    CTDi 5129.

    Phylogenomic databases

    GeneTreei ENSGT00600000083998.
    HOVERGENi HBG014652.
    InParanoidi Q5RD01.
    KOi K15596.
    OrthoDBi EOG7966H8.
    TreeFami TF106508.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiCDK18_PONAB
    AccessioniPrimary (citable) accession number: Q5RD01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: April 16, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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