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Protein

Cyclin-dependent kinase 18

Gene

CDK18

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171ATPPROSITE-ProRule annotation1
Active sitei263Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 156ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:CDK18
Synonyms:PCTAIRE3, PCTK3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864921 – 472Cyclin-dependent kinase 18Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RD01.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000000327.

Structurei

3D structure databases

ProteinModelPortaliQ5RD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 423Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOVERGENiHBG014652.
InParanoidiQ5RD01.
KOiK15596.
OrthoDBiEOG091G0CH0.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR
60 70 80 90 100
DPLQECSTFS PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD
110 120 130 140 150
IRLPQEFLQK LQMESPDLPK PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE
160 170 180 190 200
GTYATVFKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKNLKHANI
210 220 230 240 250
VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV KIFMFQLLRG
260 270 280 290 300
LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV
310 320 330 340 350
TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL
360 370 380 390 400
IFRLLGTPTE ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL
410 420 430 440 450
SSLLLYESKS RMSAEAALSH PYFRSLGERV HQLEDTASIF SLKEIQLQKD
460 470
PGYRGLAFQQ PGRGKNRRQS IF
Length:472
Mass (Da):54,224
Last modified:February 15, 2005 - v2
Checksum:i45C53C87B8539CFF
GO

Sequence cautioni

The sequence CAH90356 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858117 mRNA. Translation: CAH90356.1. Different initiation.
RefSeqiNP_001127275.1. NM_001133803.1.
XP_009236983.1. XM_009238708.1.
XP_009236987.1. XM_009238712.1.
UniGeneiPab.11890.

Genome annotation databases

GeneIDi100174332.
KEGGipon:100174332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858117 mRNA. Translation: CAH90356.1. Different initiation.
RefSeqiNP_001127275.1. NM_001133803.1.
XP_009236983.1. XM_009238708.1.
XP_009236987.1. XM_009238712.1.
UniGeneiPab.11890.

3D structure databases

ProteinModelPortaliQ5RD01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000000327.

Proteomic databases

PRIDEiQ5RD01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174332.
KEGGipon:100174332.

Organism-specific databases

CTDi5129.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOVERGENiHBG014652.
InParanoidiQ5RD01.
KOiK15596.
OrthoDBiEOG091G0CH0.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK18_PONAB
AccessioniPrimary (citable) accession number: Q5RD01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: October 5, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.