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Q5RD01

- CDK18_PONAB

UniProt

Q5RD01 - CDK18_PONAB

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Protein

Cyclin-dependent kinase 18

Gene

CDK18

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711ATPPROSITE-ProRule annotation
Active sitei263 – 2631Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 1569ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:CDK18
Synonyms:PCTAIRE3, PCTK3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Cyclin-dependent kinase 18PRO_0000086492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RD01.

Structurei

3D structure databases

ProteinModelPortaliQ5RD01.
SMRiQ5RD01. Positions 141-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 423282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00600000083998.
HOVERGENiHBG014652.
InParanoidiQ5RD01.
KOiK15596.
OrthoDBiEOG7966H8.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RD01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR
60 70 80 90 100
DPLQECSTFS PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD
110 120 130 140 150
IRLPQEFLQK LQMESPDLPK PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE
160 170 180 190 200
GTYATVFKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKNLKHANI
210 220 230 240 250
VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV KIFMFQLLRG
260 270 280 290 300
LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV
310 320 330 340 350
TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL
360 370 380 390 400
IFRLLGTPTE ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL
410 420 430 440 450
SSLLLYESKS RMSAEAALSH PYFRSLGERV HQLEDTASIF SLKEIQLQKD
460 470
PGYRGLAFQQ PGRGKNRRQS IF
Length:472
Mass (Da):54,224
Last modified:February 15, 2005 - v2
Checksum:i45C53C87B8539CFF
GO

Sequence cautioni

The sequence CAH90356.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858117 mRNA. Translation: CAH90356.1. Different initiation.
RefSeqiNP_001127275.1. NM_001133803.1.
UniGeneiPab.11890.

Genome annotation databases

EnsembliENSPPYT00000000344; ENSPPYP00000000327; ENSPPYG00000000304.
ENSPPYT00000000345; ENSPPYP00000000328; ENSPPYG00000000304.
GeneIDi100174332.
KEGGipon:100174332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858117 mRNA. Translation: CAH90356.1 . Different initiation.
RefSeqi NP_001127275.1. NM_001133803.1.
UniGenei Pab.11890.

3D structure databases

ProteinModelPortali Q5RD01.
SMRi Q5RD01. Positions 141-424.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5RD01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000000344 ; ENSPPYP00000000327 ; ENSPPYG00000000304 .
ENSPPYT00000000345 ; ENSPPYP00000000328 ; ENSPPYG00000000304 .
GeneIDi 100174332.
KEGGi pon:100174332.

Organism-specific databases

CTDi 5129.

Phylogenomic databases

GeneTreei ENSGT00600000083998.
HOVERGENi HBG014652.
InParanoidi Q5RD01.
KOi K15596.
OrthoDBi EOG7966H8.
TreeFami TF106508.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiCDK18_PONAB
AccessioniPrimary (citable) accession number: Q5RD01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3