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Q5RD01 (CDK18_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 18

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene names
Name:CDK18
Synonyms:PCTAIRE3, PCTK3
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in signal transduction cascades in terminally differentiated cells By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAH90356.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Cyclin-dependent kinase 18
PRO_0000086492

Regions

Domain142 – 423282Protein kinase
Nucleotide binding148 – 1569ATP By similarity

Sites

Active site2631Proton acceptor By similarity
Binding site1711ATP By similarity

Amino acid modifications

Modified residue121Phosphoserine By similarity
Modified residue721Phosphoserine By similarity
Modified residue871Phosphoserine By similarity
Modified residue961Phosphoserine By similarity
Modified residue1151Phosphoserine By similarity
Modified residue1301Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RD01 [UniParc].

Last modified February 15, 2005. Version 2.
Checksum: 45C53C87B8539CFF

FASTA47254,224
        10         20         30         40         50         60 
MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR DPLQECSTFS 

        70         80         90        100        110        120 
PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD IRLPQEFLQK LQMESPDLPK 

       130        140        150        160        170        180 
PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 

       190        200        210        220        230        240 
APCTAIREVS LLKNLKHANI VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV 

       250        260        270        280        290        300 
KIFMFQLLRG LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 

       310        320        330        340        350        360 
TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL IFRLLGTPTE 

       370        380        390        400        410        420 
ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL SSLLLYESKS RMSAEAALSH 

       430        440        450        460        470 
PYFRSLGERV HQLEDTASIF SLKEIQLQKD PGYRGLAFQQ PGRGKNRRQS IF 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858117 mRNA. Translation: CAH90356.1. Different initiation.
RefSeqNP_001127275.1. NM_001133803.1.
UniGenePab.11890.

3D structure databases

ProteinModelPortalQ5RD01.
SMRQ5RD01. Positions 141-424.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5RD01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000000344; ENSPPYP00000000327; ENSPPYG00000000304.
ENSPPYT00000000345; ENSPPYP00000000328; ENSPPYG00000000304.
GeneID100174332.
KEGGpon:100174332.

Organism-specific databases

CTD5129.

Phylogenomic databases

GeneTreeENSGT00600000083998.
HOVERGENHBG014652.
InParanoidQ5RD01.
KOK15596.
OrthoDBEOG7966H8.
TreeFamTF106508.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK18_PONAB
AccessionPrimary (citable) accession number: Q5RD01
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families