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Q5RD01

- CDK18_PONAB

UniProt

Q5RD01 - CDK18_PONAB

Protein

Cyclin-dependent kinase 18

Gene

CDK18

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    May play a role in signal transduction cascades in terminally differentiated cells.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei171 – 1711ATPPROSITE-ProRule annotation
    Active sitei263 – 2631Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi148 – 1569ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 18 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 18
    PCTAIRE-motif protein kinase 3
    Serine/threonine-protein kinase PCTAIRE-3
    Gene namesi
    Name:CDK18
    Synonyms:PCTAIRE3, PCTK3
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Cyclin-dependent kinase 18PRO_0000086492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Modified residuei72 – 721PhosphoserineBy similarity
    Modified residuei87 – 871PhosphoserineBy similarity
    Modified residuei96 – 961PhosphoserineBy similarity
    Modified residuei115 – 1151PhosphoserineBy similarity
    Modified residuei130 – 1301PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5RD01.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RD01.
    SMRiQ5RD01. Positions 141-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 423282Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00600000083998.
    HOVERGENiHBG014652.
    InParanoidiQ5RD01.
    KOiK15596.
    OrthoDBiEOG7966H8.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RD01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGR    50
    DPLQECSTFS PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD 100
    IRLPQEFLQK LQMESPDLPK PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE 150
    GTYATVFKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKNLKHANI 200
    VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV KIFMFQLLRG 250
    LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300
    TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL 350
    IFRLLGTPTE ETWPGVTAFS EFRTYSFPRY LPQPLISHAP RLDTDGIQLL 400
    SSLLLYESKS RMSAEAALSH PYFRSLGERV HQLEDTASIF SLKEIQLQKD 450
    PGYRGLAFQQ PGRGKNRRQS IF 472
    Length:472
    Mass (Da):54,224
    Last modified:February 15, 2005 - v2
    Checksum:i45C53C87B8539CFF
    GO

    Sequence cautioni

    The sequence CAH90356.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858117 mRNA. Translation: CAH90356.1. Different initiation.
    RefSeqiNP_001127275.1. NM_001133803.1.
    UniGeneiPab.11890.

    Genome annotation databases

    EnsembliENSPPYT00000000344; ENSPPYP00000000327; ENSPPYG00000000304.
    ENSPPYT00000000345; ENSPPYP00000000328; ENSPPYG00000000304.
    GeneIDi100174332.
    KEGGipon:100174332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858117 mRNA. Translation: CAH90356.1 . Different initiation.
    RefSeqi NP_001127275.1. NM_001133803.1.
    UniGenei Pab.11890.

    3D structure databases

    ProteinModelPortali Q5RD01.
    SMRi Q5RD01. Positions 141-424.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RD01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000000344 ; ENSPPYP00000000327 ; ENSPPYG00000000304 .
    ENSPPYT00000000345 ; ENSPPYP00000000328 ; ENSPPYG00000000304 .
    GeneIDi 100174332.
    KEGGi pon:100174332.

    Organism-specific databases

    CTDi 5129.

    Phylogenomic databases

    GeneTreei ENSGT00600000083998.
    HOVERGENi HBG014652.
    InParanoidi Q5RD01.
    KOi K15596.
    OrthoDBi EOG7966H8.
    TreeFami TF106508.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiCDK18_PONAB
    AccessioniPrimary (citable) accession number: Q5RD01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3