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Protein

Cyclin-dependent kinase 18

Gene

CDK18

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173ATPPROSITE-ProRule annotation1
Active sitei265Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 158ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:CDK18
Synonyms:PCTAIRE3, PCTK3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864921 – 474Cyclin-dependent kinase 18Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RD01.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000000327.

Structurei

3D structure databases

ProteinModelPortaliQ5RD01.
SMRiQ5RD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 425Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOVERGENiHBG014652.
InParanoidiQ5RD01.
KOiK15596.
OrthoDBiEOG091G0CH0.
TreeFamiTF106508.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNEDLQLGPL
60 70 80 90 100
GRDPLQECST FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP
110 120 130 140 150
MDIRLPQEFL QKLQMESPDL PKPLSRMSRR ASLSDIGFGK LETYVKLDKL
160 170 180 190 200
GEGTYATVFK GRSKLTENLV ALKEIRLEHE EGAPCTAIRE VSLLKNLKHA
210 220 230 240 250
NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH NVKIFMFQLL
260 270 280 290 300
RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE
310 320 330 340 350
VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL
360 370 380 390 400
HLIFRLLGTP TEETWPGVTA FSEFRTYSFP RYLPQPLISH APRLDTDGIQ
410 420 430 440 450
LLSSLLLYES KSRMSAEAAL SHPYFRSLGE RVHQLEDTAS IFSLKEIQLQ
460 470
KDPGYRGLAF QQPGRGKNRR QSIF
Length:474
Mass (Da):54,469
Last modified:March 28, 2018 - v3
Checksum:i5AD43E03D4511893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858117 mRNA. Translation: CAH90356.1.
RefSeqiNP_001127275.1. NM_001133803.1.
XP_009236983.1. XM_009238708.1.
XP_009236987.1. XM_009238712.1.
UniGeneiPab.11890.

Genome annotation databases

GeneIDi100174332.
KEGGipon:100174332.

Similar proteinsi

Entry informationi

Entry nameiCDK18_PONAB
AccessioniPrimary (citable) accession number: Q5RD01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 28, 2018
Last modified: March 28, 2018
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome