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Protein

RCC1 and BTB domain-containing protein 2

Gene

RCBTB2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 2
Alternative name(s):
Regulator of chromosome condensation and BTB domain-containing protein 2
Gene namesi
Name:RCBTB2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066461 – 551RCC1 and BTB domain-containing protein 2Add BLAST551

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006106.

Structurei

3D structure databases

ProteinModelPortaliQ5RCZ7.
SMRiQ5RCZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 115RCC1 1Add BLAST52
Repeati117 – 169RCC1 2Add BLAST53
Repeati171 – 222RCC1 3Add BLAST52
Repeati223 – 274RCC1 4Add BLAST52
Repeati276 – 326RCC1 5Add BLAST51
Repeati328 – 382RCC1 6Add BLAST55
Domaini394 – 457BTB 1PROSITE-ProRule annotationAdd BLAST64
Domaini489 – 519BTB 2PROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
Contains 6 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOVERGENiHBG053261.
InParanoidiQ5RCZ7.
KOiK11494.
OMAiGQMCSMA.
OrthoDBiEOG091G043O.
TreeFamiTF329478.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RCZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEELPLFSG DSGKPVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV
60 70 80 90 100
FGSAGNEVLY TTVNDEIFVL GTNCCGCLGL GDVQSTIEPR RLDSLNGKKI
110 120 130 140 150
ACLSYGSGPH IVLATTEGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS
160 170 180 190 200
NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTV NQPIPRRVTG
210 220 230 240 250
CLQNKVVVTI ACGQMCCMAV VDTGEVYVWG YNGNGQLGLG NSGNQPTPCR
260 270 280 290 300
VAALQGIRVQ RVACGYAHTL VLTDEGQVYA WGANSYGQLG TGNKSNQSYP
310 320 330 340 350
TPVTVEKDRI IEIAACHSTH TSAAKTQGGH VYMWGQCRGQ SVILPHLTHF
360 370 380 390 400
SCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV
410 420 430 440 450
DGKYIYAHKV LLKIRCEHFR SSLEDNEDDI VEMSEFSYPV YRAFLEYLYT
460 470 480 490 500
DSISLSPEEA VGLLDLATFY RENRLKKLCQ QTIKQGICEE NAIALLSAAV
510 520 530 540 550
KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK

N
Length:551
Mass (Da):60,315
Last modified:December 21, 2004 - v1
Checksum:i0965A7FAC8143F03
GO
Isoform 2 (identifier: Q5RCZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):57,769
Checksum:iCA61AA50A0CEEA10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84Q → R in CAH91921 (Ref. 1) Curated1
Sequence conflicti417E → G in CAH89917 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0167251 – 24Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857643 mRNA. Translation: CAH89917.1.
CR858121 mRNA. Translation: CAH90360.1.
CR859763 mRNA. Translation: CAH91921.1.
RefSeqiNP_001125174.1. NM_001131702.1. [Q5RCZ7-1]
NP_001128757.1. NM_001135285.1.
UniGeneiPab.12762.

Genome annotation databases

EnsembliENSPPYT00000006345; ENSPPYP00000006106; ENSPPYG00000005361. [Q5RCZ7-1]
GeneIDi100172062.
KEGGipon:100172062.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857643 mRNA. Translation: CAH89917.1.
CR858121 mRNA. Translation: CAH90360.1.
CR859763 mRNA. Translation: CAH91921.1.
RefSeqiNP_001125174.1. NM_001131702.1. [Q5RCZ7-1]
NP_001128757.1. NM_001135285.1.
UniGeneiPab.12762.

3D structure databases

ProteinModelPortaliQ5RCZ7.
SMRiQ5RCZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000006345; ENSPPYP00000006106; ENSPPYG00000005361. [Q5RCZ7-1]
GeneIDi100172062.
KEGGipon:100172062.

Organism-specific databases

CTDi1102.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOVERGENiHBG053261.
InParanoidiQ5RCZ7.
KOiK11494.
OMAiGQMCSMA.
OrthoDBiEOG091G043O.
TreeFamiTF329478.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCBT2_PONAB
AccessioniPrimary (citable) accession number: Q5RCZ7
Secondary accession number(s): Q5R8I9, Q5RE90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.