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Protein

Cytochrome b561

Gene

CYB561

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secretory vesicle-specific electron transport protein.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi91Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi109Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi121Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi160Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 251CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510301 – 251Cytochrome b561Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009572.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 220Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOVERGENiHBG054164.
InParanoidiQ5RCZ2.
KOiK08360.
OMAiGSAHEFN.
OrthoDBiEOG091G0GC6.
TreeFamiTF314222.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RCZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGAAASTP AALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF
60 70 80 90 100
NAHPLCMVIG LIFLQGDALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV
110 120 130 140 150
GLVAVFDYHR KEGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF
160 170 180 190 200
SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFKLRDK YSAFEPEGVL
210 220 230 240 250
ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS

Q
Length:251
Mass (Da):27,718
Last modified:December 21, 2004 - v1
Checksum:i90AA2DCCCD99A199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858126 mRNA. Translation: CAH90365.1.
RefSeqiNP_001125175.1. NM_001131703.1.
XP_009250170.1. XM_009251895.1.
XP_009250171.1. XM_009251896.1.
UniGeneiPab.13949.

Genome annotation databases

EnsembliENSPPYT00000009955; ENSPPYP00000009572; ENSPPYG00000008522.
GeneIDi100172064.
KEGGipon:100172064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858126 mRNA. Translation: CAH90365.1.
RefSeqiNP_001125175.1. NM_001131703.1.
XP_009250170.1. XM_009251895.1.
XP_009250171.1. XM_009251896.1.
UniGeneiPab.13949.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000009955; ENSPPYP00000009572; ENSPPYG00000008522.
GeneIDi100172064.
KEGGipon:100172064.

Organism-specific databases

CTDi1534.

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOVERGENiHBG054164.
InParanoidiQ5RCZ2.
KOiK08360.
OMAiGSAHEFN.
OrthoDBiEOG091G0GC6.
TreeFamiTF314222.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY561_PONAB
AccessioniPrimary (citable) accession number: Q5RCZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.