Reviewed,
UniProtKB/Swiss-Prot Q5RCY2 (NUDT5_PONAB)
Last modified
May 5, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: ADP-sugar pyrophosphatase EC=3.6.1.13 EC=3.6.1.- Alternative name(s): Nucleoside diphosphate-linked moiety X motif 5 Short name=Nudix motif 5 | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity By similarity. |
| Catalytic activity | ADP-ribose + H2O = AMP + D-ribose 5-phosphate. ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate. |
| Cofactor | Magnesium By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the Nudix hydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Magnesium |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Molecular function | ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 216 | 216 | ADP-sugar pyrophosphatase | PRO_0000250702 | |||||
Regions | |||||||||
| Motif | 97 – 118 | 22 | Nudix box | ||||||
Amino acid modifications | |||||||||
| Modified residue | 9 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 10 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 74 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart. |
Cross-references
Sequence databases | |
|---|---|
| CR858136 mRNA. Translation: CAH90375.1. | |
| RefSeq | NP_001125182.1. |
| UniGene | Pab.13961 |
3D structure databases | |
| SMR | Q5RCY2. Positions 14-216. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100172071. |
Phylogenomic databases | |
| HOVERGEN | Q5RCY2. |
Enzyme and pathway databases | |
| BRENDA | 3.6.1.13. 269192. |
Family and domain databases | |
| InterPro | IPR000086. NUDIX_hydrolase_core. [Graphical view] |
| Gene3D | G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit. |
| Pfam | PF00293. NUDIX. 1 hit. [Graphical view] |
| PROSITE | PS00893. NUDIX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NUDT5_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5RCY2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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