Reviewed, UniProtKB/Swiss-Prot Q5RCY2 (NUDT5_PONAB)

Names and origin

Protein names

Recommended name:
    ADP-sugar pyrophosphatase
    EC=3.6.1.13
    EC=3.6.1.-
Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 5
      Short name=Nudix motif 5

Gene names

Name:

NUDT5

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity By similarity.
Catalytic activity	ADP-ribose + H2O = AMP + D-ribose 5-phosphate. ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate.
Cofactor	Magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	ADP-sugar pyrophosphatase		PRO_0000250702
Regions
	Motif	97 – 118	22	Nudix box
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	10	1	Phosphoserine By similarity
	Modified residue	74	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RCY2-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 9C88CC433D3CC3A9	FASTA	216	24,070
	10 20 30 40 50 60 MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD 70 80 90 100 110 120 GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK 130 140 150 160 170 180 GDVAECSPAV CMDPGLSNCT VHIVTVTING DDAENARPKP KPEFVEVISL PKNDLLQRLD 190 200 210 ALVAEEHLTV DARVYSYALA LKHANAKPFE VPFLKF

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR858136 mRNA. Translation: CAH90375.1.
RefSeq	NP_001125182.1.
UniGene	Pab.13961
3D structure databases
SMR	Q5RCY2. Positions 14-216.
ModBase	Search...
Genome annotation databases
GeneID	100172071.
Phylogenomic databases
HOVERGEN	Q5RCY2.
Enzyme and pathway databases
BRENDA	3.6.1.13. 269192.
Family and domain databases
InterPro	IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDT5_PONAB

Accession

Primary (citable) accession number: Q5RCY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 21, 2004
Last modified:	May 5, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)