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Protein

Transcription initiation factor IIA subunit 1

Gene

GTF2A1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 1
Alternative name(s):
General transcription factor IIA subunit 1
Cleaved into the following 2 chains:
Alternative name(s):
TFIIA p35 subunit
Alternative name(s):
TFIIA p19 subunit
Gene namesi
Name:GTF2A1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000425982 – 376Transcription initiation factor IIA subunit 1Add BLAST375
ChainiPRO_00000425992 – 274Transcription initiation factor IIA alpha chainAdd BLAST273
ChainiPRO_0000042600275 – 376Transcription initiation factor IIA beta chainAdd BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei280Phosphoserine; by TAF1By similarity1
Modified residuei281Phosphoserine; by TAF1By similarity1
Modified residuei316Phosphoserine; by TAF1By similarity1
Modified residuei321Phosphoserine; by TAF1By similarity1

Post-translational modificationi

The alpha and beta subunits are postranslationally produced from the precursor formby TASP1. The cleavage promotes proteasomal degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei274 – 275Cleavage; by TASP12

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

TFIIA is a heterodimer of a unprocessed large subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit. TFIIA forms a complex with TBP (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006871.

Structurei

3D structure databases

ProteinModelPortaliQ5RCU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 80Poly-Gln10
Compositional biasi81 – 87Poly-His7

Sequence similaritiesi

Belongs to the TFIIA subunit 1 family.Curated

Phylogenomic databases

eggNOGiENOG410IPCF. Eukaryota.
ENOG4111M8K. LUCA.
HOVERGENiHBG052771.
InParanoidiQ5RCU0.
KOiK03122.

Family and domain databases

CDDicd07976. TFIIA_alpha_beta_like. 2 hits.
Gene3Di2.30.18.10. 1 hit.
InterProiView protein in InterPro
IPR009083. TFIIA_a-hlx.
IPR004855. TFIIA_asu/bsu.
IPR009088. TFIIA_b-brl.
PfamiView protein in Pfam
PF03153. TFIIA. 2 hits.
SMARTiView protein in SMART
SM01371. TFIIA. 1 hit.
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL
60 70 80 90 100
MQSRAVDGFH SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA
110 120 130 140 150
QTQQVLIPAS QQATAPQVIV PDSKLIQHMN ASNMSAAATA ATLALPAGVT
160 170 180 190 200
PVQQILTNSG QLLQVVRVAN GAQYIFQPQQ SVVLQQQVIP QMQPGGVQAP
210 220 230 240 250
VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV AAPTPAQAQI
260 270 280 290 300
TATGHQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE
310 320 330 340 350
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK
360 370
FHLKDGIMNL NGRDYIFSKA IGDAEW
Length:376
Mass (Da):41,551
Last modified:December 21, 2004 - v1
Checksum:iB419A6CAAF511249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858178 mRNA. Translation: CAH90417.1.
RefSeqiNP_001125209.1. NM_001131737.1.
UniGeneiPab.6707.

Genome annotation databases

GeneIDi100172100.
KEGGipon:100172100.

Similar proteinsi

Entry informationi

Entry nameiTF2AA_PONAB
AccessioniPrimary (citable) accession number: Q5RCU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families