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Protein

Frizzled-6

Gene

FZD6

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Neurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-6
Short name:
Fz-6
Gene namesi
Name:FZD6
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cell surface By similarity
  • Apical cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Colocalizes with FZD3 at the apical face of cells (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 202183ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini224 – 23411CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini256 – 28530ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini307 – 32519CytoplasmicSequence analysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini347 – 37125ExtracellularSequence analysisAdd
BLAST
Transmembranei372 – 39221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini393 – 41725CytoplasmicSequence analysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini439 – 47436ExtracellularSequence analysisAdd
BLAST
Transmembranei475 – 49521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini496 – 707212CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 707688Frizzled-6PRO_0000243938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 86PROSITE-ProRule annotation
Disulfide bondi33 ↔ 79PROSITE-ProRule annotation
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi70 ↔ 107PROSITE-ProRule annotation
Disulfide bondi96 ↔ 130PROSITE-ProRule annotation
Disulfide bondi100 ↔ 124PROSITE-ProRule annotation
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Modified residuei654 – 6541PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021096.

Structurei

3D structure databases

ProteinModelPortaliQ5RCN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 133114FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi498 – 5036Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.
InParanoidiQ5RCN4.
KOiK02376.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMFTFFLLT CIFLPLVRGH SLFTCEPITV PRCMKMAYNM TFFPNLMGHY
60 70 80 90 100
DQSIAAVEME HFLPLANLEC SPNIETFLCK AFVPTCTEQI HVVPPCRKLC
110 120 130 140 150
EKVYSDCKKL IDTFGIRWPE ELECDRLQYC DETVPVTFDP HTEFLGPQKK
160 170 180 190 200
TEQVQRDIGF WCPRHLKTSG GQGYKFLGID QCAPPCPNMY FKSDELEFAK
210 220 230 240 250
SFIGTVSIFC LCATLFTFLT FLIDVRRFRY PERPIIYYSV CYSIVSLMYF
260 270 280 290 300
IGFLLGDSTA CNKADEKLEL GDTVVLGSQN KACTVLFMLL YFFTMAGTVW
310 320 330 340 350
WVILTITWFL AAGRKWSCEA IEQKAVWFHA VAWGTPGFLT VMLLAMNKVE
360 370 380 390 400
GDNISGVCFV GLYDLDASRY FVLLPLCLCV FVGLSLLLAG IISLNHVRQV
410 420 430 440 450
IQHDGRNQEK LKKFMIRIGV FSGLYLVPLV TLLGCYVYEQ VNRITWEITW
460 470 480 490 500
VSDHCRQYHI PCPYQAKAKA RPELALFMIK YLMTLIVGIS AVFWVGSKKT
510 520 530 540 550
CTEWAGFFKR NRKRDPISES RRVLQESCEF FLKHNSKVKH KKKHYKPSSH
560 570 580 590 600
KLKVISKSMG TSTGATANHG TSAVAITSHD YLGQETLTEI QTSPETSMRE
610 620 630 640 650
VKADGASTPR LREQDCGEPA SPAASISRLS GEQVDRKGQA GSVSESARSE
660 670 680 690 700
GRISPKSDIT DTGLAQSNNL QVPSSSEPSS LKGSTSLLVH PVSGVRKEQG

GGCHSDT
Length:707
Mass (Da):79,512
Last modified:December 21, 2004 - v1
Checksum:i8898BD05E1615889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858236 mRNA. Translation: CAH90473.1.
RefSeqiNP_001125247.1. NM_001131775.2.
UniGeneiPab.8120.

Genome annotation databases

GeneIDi100172142.
KEGGipon:100172142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858236 mRNA. Translation: CAH90473.1.
RefSeqiNP_001125247.1. NM_001131775.2.
UniGeneiPab.8120.

3D structure databases

ProteinModelPortaliQ5RCN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021096.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172142.
KEGGipon:100172142.

Organism-specific databases

CTDi8323.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.
InParanoidiQ5RCN4.
KOiK02376.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFZD6_PONAB
AccessioniPrimary (citable) accession number: Q5RCN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.