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Q5RCH8

- PECR_PONAB

UniProt

Q5RCH8 - PECR_PONAB

Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

PECR

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 4725NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
    2. phytol metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
    Short name:
    TERP
    Gene namesi
    Name:PECR
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 303302Peroxisomal trans-2-enoyl-CoA reductasePRO_0000054742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei32 – 321N6-succinyllysineBy similarity

    Interactioni

    Subunit structurei

    Interacts with PEX5, probably required to target it into peroxisomes.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RCH8.
    SMRiQ5RCH8. Positions 7-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi301 – 3033Microbody targeting signalBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG105268.
    InParanoidiQ5RCH8.
    KOiK07753.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RCH8-1 [UniParc]FASTAAdd to Basket

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    MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR    50
    KLERLKSAAG ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDIFGK 100
    INFLVNNGGG QFLSLAEHIS SKGWHAVLET NLTGTFYMCK AVYSSWMKEH 150
    GGSIVNIIVS IKTGLPLAVH SGAARAGVYN LTKSLALEWA CSGVRINCVA 200
    PGVIYSQTAV ENYGSYGQSF FEESFQKIPA KRIGVPEEVS SVVCFLLSPA 250
    ASFITGQSVD VDGGRSLYTH SYEIPDHDNW PKGAGDLSVV KRMKETFKEK 300
    AKL 303
    Length:303
    Mass (Da):32,589
    Last modified:December 21, 2004 - v1
    Checksum:i7B152CFB5C10A1E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858292 mRNA. Translation: CAH90529.1.
    RefSeqiNP_001127299.1. NM_001133827.2.
    UniGeneiPab.11557.

    Genome annotation databases

    GeneIDi100174357.
    KEGGipon:100174357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858292 mRNA. Translation: CAH90529.1 .
    RefSeqi NP_001127299.1. NM_001133827.2.
    UniGenei Pab.11557.

    3D structure databases

    ProteinModelPortali Q5RCH8.
    SMRi Q5RCH8. Positions 7-303.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174357.
    KEGGi pon:100174357.

    Organism-specific databases

    CTDi 55825.

    Phylogenomic databases

    HOVERGENi HBG105268.
    InParanoidi Q5RCH8.
    KOi K07753.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPECR_PONAB
    AccessioniPrimary (citable) accession number: Q5RCH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3