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Q5RCH8

- PECR_PONAB

UniProt

Q5RCH8 - PECR_PONAB

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Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

PECR

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 4725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  2. phytol metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Short name:
TERP
Gene namesi
Name:PECR
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 303302Peroxisomal trans-2-enoyl-CoA reductasePRO_0000054742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321N6-succinyllysineBy similarity

Interactioni

Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RCH8.
SMRiQ5RCH8. Positions 7-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi301 – 3033Microbody targeting signalBy similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG105268.
InParanoidiQ5RCH8.
KOiK07753.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR
60 70 80 90 100
KLERLKSAAG ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDIFGK
110 120 130 140 150
INFLVNNGGG QFLSLAEHIS SKGWHAVLET NLTGTFYMCK AVYSSWMKEH
160 170 180 190 200
GGSIVNIIVS IKTGLPLAVH SGAARAGVYN LTKSLALEWA CSGVRINCVA
210 220 230 240 250
PGVIYSQTAV ENYGSYGQSF FEESFQKIPA KRIGVPEEVS SVVCFLLSPA
260 270 280 290 300
ASFITGQSVD VDGGRSLYTH SYEIPDHDNW PKGAGDLSVV KRMKETFKEK

AKL
Length:303
Mass (Da):32,589
Last modified:December 21, 2004 - v1
Checksum:i7B152CFB5C10A1E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858292 mRNA. Translation: CAH90529.1.
RefSeqiNP_001127299.1. NM_001133827.2.
UniGeneiPab.11557.

Genome annotation databases

GeneIDi100174357.
KEGGipon:100174357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858292 mRNA. Translation: CAH90529.1 .
RefSeqi NP_001127299.1. NM_001133827.2.
UniGenei Pab.11557.

3D structure databases

ProteinModelPortali Q5RCH8.
SMRi Q5RCH8. Positions 7-303.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174357.
KEGGi pon:100174357.

Organism-specific databases

CTDi 55825.

Phylogenomic databases

HOVERGENi HBG105268.
InParanoidi Q5RCH8.
KOi K07753.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPECR_PONAB
AccessioniPrimary (citable) accession number: Q5RCH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3