Reviewed, UniProtKB/Swiss-Prot Q5RCH8 (PECR_PONAB)

Names and origin

Protein names

Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase
    EC=1.3.1.38

Gene names

Name:

PECR

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Interacts with PEX5, probably required to target it into peroxisomes By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Peroxisome
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Peroxisomal trans-2-enoyl-CoA reductase		PRO_0000054742
Regions
	Nucleotide binding	23 – 47	25	NADP By similarity
	Motif	301 – 303	3	Microbody targeting signal By similarity
Sites
	Active site	179	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	179	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RCH8-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 7B152CFB5C10A1E1	FASTA	303	32,589
	10 20 30 40 50 60 MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR KLERLKSAAG 70 80 90 100 110 120 ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDIFGK INFLVNNGGG QFLSLAEHIS 130 140 150 160 170 180 SKGWHAVLET NLTGTFYMCK AVYSSWMKEH GGSIVNIIVS IKTGLPLAVH SGAARAGVYN 190 200 210 220 230 240 LTKSLALEWA CSGVRINCVA PGVIYSQTAV ENYGSYGQSF FEESFQKIPA KRIGVPEEVS 250 260 270 280 290 300 SVVCFLLSPA ASFITGQSVD VDGGRSLYTH SYEIPDHDNW PKGAGDLSVV KRMKETFKEK AKL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR858292 mRNA. Translation: CAH90529.1.
RefSeq	NP_001127299.1.
UniGene	Pab.11557
3D structure databases
SMR	Q5RCH8. Positions 7-303.
ModBase	Search...
Genome annotation databases
GeneID	100174357.
Phylogenomic databases
HOVERGEN	Q5RCH8.
Enzyme and pathway databases
BRENDA	1.3.1.38. 269192.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PECR_PONAB

Accession

Primary (citable) accession number: Q5RCH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)