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Q5RCH8 (PECR_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal trans-2-enoyl-CoA reductase

Short name=TERP
EC=1.3.1.38
Gene names
Name:PECR
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Interacts with PEX5, probably required to target it into peroxisomes By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentPeroxisome
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

phytol metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

peroxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontrans-2-enoyl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 303302Peroxisomal trans-2-enoyl-CoA reductase
PRO_0000054742

Regions

Nucleotide binding23 – 4725NADP By similarity
Motif301 – 3033Microbody targeting signal By similarity

Sites

Active site1791Proton acceptor By similarity

Amino acid modifications

Modified residue321N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RCH8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 7B152CFB5C10A1E1

FASTA30332,589
        10         20         30         40         50         60 
MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR KLERLKSAAG 

        70         80         90        100        110        120 
ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDIFGK INFLVNNGGG QFLSLAEHIS 

       130        140        150        160        170        180 
SKGWHAVLET NLTGTFYMCK AVYSSWMKEH GGSIVNIIVS IKTGLPLAVH SGAARAGVYN 

       190        200        210        220        230        240 
LTKSLALEWA CSGVRINCVA PGVIYSQTAV ENYGSYGQSF FEESFQKIPA KRIGVPEEVS 

       250        260        270        280        290        300 
SVVCFLLSPA ASFITGQSVD VDGGRSLYTH SYEIPDHDNW PKGAGDLSVV KRMKETFKEK 


AKL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858292 mRNA. Translation: CAH90529.1.
RefSeqNP_001127299.1. NM_001133827.2.
UniGenePab.11557.

3D structure databases

ProteinModelPortalQ5RCH8.
SMRQ5RCH8. Positions 7-303.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174357.
KEGGpon:100174357.

Organism-specific databases

CTD55825.

Phylogenomic databases

HOVERGENHBG105268.
InParanoidQ5RCH8.
KOK07753.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
ProtoNetSearch...

Entry information

Entry namePECR_PONAB
AccessionPrimary (citable) accession number: Q5RCH8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: March 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways